Scott R. Presnell - Tacoma WA Darrell C. Conklin - Seattle WA Julia E. Novak - Bainbridge Island WA Angela K. Hammond - Issaquah WA
Assignee:
ZymoGenetics, Inc. - Seattle WA
International Classification:
C07K 1452
US Classification:
530351, 530350, 5303873, 435 72, 435 697, 435335
Abstract:
Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zalpha11, are located on chromosome 16, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
Methods Of Using Cytokine Receptor Zalpha11 To Detect Its Ligands
Scott R. Presnell - Tacoma WA Darrell C. Conklin - Seattle WA Julia E. Novak - Bainbridge Island WA Angela K. Hammond - Issaquah WA
Assignee:
ZymoGenetics, Inc. - Seattle WA
International Classification:
G01N 3353
US Classification:
435 71, 530350, 530351, 435 72, 435 697
Abstract:
Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zalpha11, are located on chromosome 16, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
Scott R. Presnell - Tacoma WA Darrell C. Conklin - Seattle WA Julia E. Novak - Bainbridge Island WA Angela K. Hammond - Maple Valley WA
Assignee:
ZymoGenetics, Inc. - Seattle WA
International Classification:
C07K 1452
US Classification:
530351, 5303873, 530395, 435335
Abstract:
Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zalpha11, are located on chromosome 16, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
The polypeptides, and the polynucleotides encoding for them, described herein are IL-21 antagonists that bind with specificity and exhibit an ECthat is not detectable in receptor binding studies. These molecules have mutations in the D helix of the IL-21 molecule, and can be used to inhibit the activity of IL-21 with its cognate receptor.
Scott R. Presnell - Tacoma WA, US James W. West - Seattle WA, US Julia E. Novak - Bainbridge Island WA, US
Assignee:
ZymoGenetics, Inc. - Seattle WA
International Classification:
C07K 14/47 C07K 14/475
US Classification:
530351, 435 691, 514 12, 536 235
Abstract:
The polypeptides, and the polynucleotides encoding for them, described herein are IL-21 antagonists that bind with specificity and exhibit an ECthat is not detectable in receptor binding studies. These molecules have mutations in the D helix of the IL-21 molecule, and can be used to inhibit the activity of IL-21 with its cognate receptor.
The polypeptides, and the polynucleotides encoding for them, described herein are IL-21 antagonists that bind with specificity and exhibit an ECthat is not detectable in receptor binding studies. These molecules have mutations in the D helix of the IL-21 molecule, and can be used to inhibit the activity of IL-21 with its cognate receptor.
Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zalpha11, are located on chromosome 16, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
Scott R. Presnell - Tacoma WA, US Wenfeng Xu - Mukilteo WA, US Julia E. Novak - Bainbridge Island WA, US Theodore E. Whitmore - Redmond WA, US Francis J. Grant - Seattle WA, US
Assignee:
ZymoGenetics, LLC - Nashville TN
International Classification:
C07K 14/715 C07K 14/54
US Classification:
530350, 530351
Abstract:
Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor19, a novel class II cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor19, are located on chromosome 1p36. 11, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
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