Julie R Novak

US Patent:

20100074905, Mar 25, 2010

Filed:

Sep 16, 2009

Appl. No.:

12/560637

Inventors:

Cindy A. Sprecher - Seattle WA, US
Julie E. Novak - Bainbridge Island WA, US
James W. West - Seattle WA, US
Richard D. Holly - Seattle WA, US
Andrew J. Nelson - Shoreline WA, US

International Classification:

A61K 39/395
A61K 38/16
A61P 37/06

US Classification:

4241581, 514 12

Abstract:

Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for soluble zalpha11 receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block zalpha11 Ligand activity in vitro and in vivo, and may be used in conjunction with zalpha11 Ligand and other cytokines to selectively stimulate the immune system. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

Author:

Julie C. Novak

ISBN #:

0323003222

Author:

Julie C. Novak

ISBN #:

0323003257

Author:

Julie C. Novak

ISBN #:

0815164483