Yajing Chen

US Patent:

59728990, Oct 26, 1999

Filed:

Jan 25, 1996

Appl. No.:

8/591079

Inventors:

Arturo Zychlinsky - New York NY
Yajing Chen - Elmhurst NY

Assignee:

New York University - New York NY

International Classification:

A61K 4800
C12N 1531
C12N 1585

US Classification:

514 44

Abstract:

Shigella IpaB protein or functional derivative binds to interleukin-1. beta. -converting enzyme (ICE) or an ICE homologue and activates a program of apoptosis. DNA encoding the Shigella IpaB protein, the IpaB protein or a functional derivative thereof is provided to a eukaryotic, preferably human, cell to induce apoptosis of that cell. This approach useful in treating diseases or disorders treatable by the eradication of unwanted cells, including cancer, autoimmunity, inflammation and chronic viral infections. Protein or peptide molecules (and the DNA coding therefor) which act as competitive antagonists for ICE binding without activating the apoptosis program are useful in treating or preventing diseases which involve an apoptotic mechanisms in their pathogenesis, for example AIDS, degenerative diseases such as Alzheimer's disease, myelodysplastic disorders, ischemic injuries or toxin-induced liver diseases. Various methods of gene therapy relying upon controlled expression of IpaB in a target cell are disclosed. Also provided are methods for: inhibiting the interaction of an apoptosis-inducing protein or peptide with ICE, detecting a compound capable of inhibiting the binding of IpaB to ICE or to an ICE homologue, screening a candidate protein or peptide for its ability to interact with IpaB in a cell, isolating from a complex mixture a compound capable of binding to IpaB protein.

US Patent:

20190002539, Jan 3, 2019

Filed:

Jan 26, 2017

Appl. No.:

16/075211

Inventors:

- Beijing, CN
- La Jolla CA, US
Yuxing Li - La Jolla CA, US
Ian A. Wilson - La Jolla CA, US
Leopold Kong - La Jolla CA, US
Bin Ju - Beijing, CN
Linling He - La Jolla CA, US
Li Ren - Beijing, CN
Yajing Chen - La Jolla CA, US
Jiandong Liu - Beijing, CN

International Classification:

C07K 16/10
A61P 31/18
C12N 15/113
G01N 33/569
G01N 33/577

Abstract:

Broadly neutralizing antibodies against HIV-1 which specifically bind to gp120 of HIV-1, a method of preparing such antibodies and the use thereof are provided.