Wesley S Wong

US Patent:

20100137120, Jun 3, 2010

Filed:

Dec 2, 2008

Appl. No.:

12/326279

Inventors:

Wesley P. Wong - Cambridge MA, US
Kenneth A. Halvorsen - Natick MA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

B04B 5/12

US Classification:

494 10, 494 37

Abstract:

A spinning force system and methods of operation are provided for measuring a characteristic of a sample. The system includes a detection module having a light source for illuminating the sample and an objective being aligned to the light source to define a light path for producing an image of the sample. A rotor is mechanically coupled to the detection module and configured to rotate the light path for applying a force to the sample. The force may include a centrifugal force and other forms of force (such as a viscous drag force) resulted from the rotation. In some examples, the force is applied in a direction that is not parallel to a surface of the sample.

US Patent:

20110193987, Aug 11, 2011

Filed:

Aug 5, 2009

Appl. No.:

13/057623

Inventors:

Wesley Philip Wong - Cambridge MA, US
Kenneth Anders Halvorsen - Natick MA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

G06K 9/00
H04N 5/225

US Classification:

3482221, 382168, 382100, 382103, 348E05024

Abstract:

Methods, apparatus and systems for determining a power spectral density (PSD) of a signal, in which modulation of the signal is employed to facilitate determination of one or more PSD values over a wide range of frequencies. In some implementations, the signal may represent a wide-sense stationary random process. In one example, the signal is measured/sampled during a plurality of measurement windows, during which an intensity of the signal is modulated at one or more modulation frequencies. A variance of a set of quantities determined from the signal samples is calculated and used to determine respective values of the power spectral density (PSD) for the signal at the one or more modulation frequencies. The one or more modulation frequencies may be chosen in excess of the Nyquist frequency of the sampling process, such that the signal may be characterized for one or more frequencies above the Nyquist limit.

US Patent:

20130130884, May 23, 2013

Filed:

Jun 1, 2011

Appl. No.:

13/701042

Inventors:

Wesley Philip Wong - Cambridge MA, US
Kenneth Anders Halvorsen - Natick MA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

G01N 24/00

US Classification:

494 10

Abstract:

An apparatus for measuring a characteristic of a sample includes a sample measurement apparatus (), which includes a light source () configured to illuminate the sample; and a detector () configured to receive light from the sample. The sample measurement apparatus is sized and dimensioned to fit within a centrifuge receptacle, the centrifuge receptacle () coupled to a spindle configured to rotate the centrifuge receptacle to apply a force to the sample.

US Patent:

20210239602, Aug 5, 2021

Filed:

Feb 4, 2021

Appl. No.:

17/167847

Inventors:

- Cambridge MA, US
- Boston MA, US
Wesley Philip Wong - Cambridge MA, US
Kenneth Anders Halvorsen - Glenmont NY, US

Assignee:

President and Fellows of Harvard College - Cambridge MA
Children's Medical Center Corporation - Boston MA

International Classification:

G01N 21/07
B82Y 15/00
G01N 33/53
C12Q 1/68
C12Q 1/6816
G01N 33/543
G01N 15/14
G01N 33/557

Abstract:

An apparatus for measuring a characteristic of a sample using a centrifuge and optical components is disclosed. The centrifuge may be a standard benchtop centrifuge. The optical components may be sized and dimensioned to fit, along with the sample, inside the centrifuge.

US Patent:

20200116712, Apr 16, 2020

Filed:

Mar 23, 2017

Appl. No.:

16/088006

Inventors:

- Boston MA, US
Wesley Philip Wong - Cambridge MA, US
Darren Yang - Somerville MA, US
Andrew Ward - Everett MA, US

Assignee:

Children's Medical Center Corporation - Boston MA

International Classification:

G01N 33/543
G01N 27/447
C12Q 1/6834

Abstract:

Provided herein, inter alia, are improved methods for detecting analytes, including proteins and nucleic acids. In some instances, the analytes are detected in complex matrices such as serum.

US Patent:

20190345193, Nov 14, 2019

Filed:

Dec 5, 2017

Appl. No.:

16/466973

Inventors:

- Boston MA, US
- Cambridge MA, US
Hongyu Zhao - Boston MA, US
Andrew Ward - Boston MA, US
Clinton H. Hansen - Cambridge MA, US
Wesley Philip Wong - Cambridge MA, US

Assignee:

Children's Medical Center Corporation - Boston MA
President and Fellows of Harvard College - Cambridge MA

International Classification:

C07H 21/04
C12N 15/11
C12N 15/63

Abstract:

This disclosure provides methods for generating functionalized nanoswitches, as well as the functionalized nanoswitches themselves, and methods of use thereof.

US Patent:

20190064056, Feb 28, 2019

Filed:

Feb 24, 2017

Appl. No.:

16/079995

Inventors:

- Boston MA, US
- Cambridge MA, US
Wesley Philip Wong - Cambridge MA, US
Kenneth Anders Halvorsen - Glenmont NY, US

Assignee:

Children's Medical Center Corporation - Boston MA
President and Fellows of Harvard College - Cambridge MA

International Classification:

G01N 21/07
G01N 33/557

Abstract:

An apparatus for measuring a characteristic of a sample using a centrifuge and optical components is disclosed. The centrifuge may be a standard benchtop centrifuge. The optical components may be sized and dimensioned to fit, along with the sample, inside the centrifuge.

US Patent:

20170369935, Dec 28, 2017

Filed:

Nov 16, 2015

Appl. No.:

15/533473

Inventors:

- Boston MA, US
- Cambridge MA, US
Andrew Ward - Boston MA, US
Wesley Philip Wong - Cambridge MA, US

Assignee:

Children's Medical Center Corporation - Boston MA
President and Fellows of Harvard College - Cambridge MA

International Classification:

C12Q 1/68
C12P 19/34
G01N 27/447

Abstract:

The invention provides compositions comprising nucleic acid complexes for use in monitoring binding interactions and in measuring association and/or dissociation kinetics, detecting analytes including low concentration analytes, and screening library members. In some instances, the nucleic acid complexes are double-stranded nicked nucleic acids comprising a scaffold nucleic acid hybridized to one or more oligonucleotides. In some instances, a first, a second, a third, and optionally a fourth oligonucleotide are linked to moieties that are known to interact with each other or which are suspected of interacting with each other or of interacting with a common moiety such as an analyte. Changes in topology of the complex are used to determine the binding interactions of the various binding partners.