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Weizao Chen

age ~43

from Frederick, MD

Also known as:
  • Wei Chen

Weizao Chen Phones & Addresses

  • Frederick, MD

Us Patents

  • Human Domain Antibodies Against Components Of The Human Insulin-Like Growth Factor (Igf) System

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  • US Patent:
    20120195897, Aug 2, 2012
  • Filed:
    Oct 7, 2010
  • Appl. No.:
    13/499758
  • Inventors:
    Dimiter S. Dimitrov - Frederick MD,
    Weizao Chen - Frederick MD,
  • International Classification:
    A61K 39/395
    C07K 16/28
    C07K 16/46
    C07K 19/00
    C12N 15/13
    C12N 15/62
    C12N 1/21
    C12N 1/19
    C12N 5/10
    A61K 31/7088
    A61P 35/00
    C12P 21/02
    C12N 15/63
    G01N 33/566
    C07K 16/22
  • US Classification:
    4241341, 5303873, 5303911, 5303913, 5303917, 536 2353, 536 234, 4241331, 43525233, 43525231, 4352523, 43525234, 43525421, 435328, 4241781, 514 44 R, 435 696, 4353201, 436501, 435 71
  • Abstract:
    The invention provides antibodies or antibody fragments that bind to insulin-like growth factor (IGF) 1 receptor (IGF-1R) or IGF-2, as well as method of using the antibodies for inhibiting the IGF-mediated signaling pathway, inhibiting IGF-1R signaling, and treating cancer. The invention also provides a method of detecting the presence of IGF-1R or IGF-2 in a sample using the inventive antibodies and antibody fragments.
  • High-Affinity Fully Functional Soluble Single-Domain Human Cd4, Antibodies, And Related Fusion Proteins

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  • US Patent:
    20130108636, May 2, 2013
  • Filed:
    May 20, 2011
  • Appl. No.:
    13/699535
  • Inventors:
    Dimiter S. Dimitrov - Frederick MD,
    Weizao Chen - Frederick MD,
  • International Classification:
    C07K 16/10
  • US Classification:
    4241341, 5303875, 4241371, 536 2353, 5303873, 4353201, 514 44 R
  • Abstract:
    The invention provides engineered antibody domains (eAds), a polypeptide comprising a single domain CD4, as well as a fusion protein comprising the same. Nucleic acids encoding eAd and/or polypeptide or the fusion protein thereof, as well as compositions or cells comprising the eAd, polypeptide, fusion protein, or nucleic acid also are provided.
  • Anti-Hiv Domain Antibodies And Method Of Making And Using Same

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  • US Patent:
    20110104163, May 5, 2011
  • Filed:
    Jan 7, 2009
  • Appl. No.:
    12/811998
  • Inventors:
    Dimiter S. Dimitrov - Frederick MD,
    Weizao Chen - Frederick MD,
  • Assignee:
    THE UNITED STATES OF AMERICA, AS REPRESENTED BY TH - ROCKVILLE MD
  • International Classification:
    A61K 39/42
    C07K 16/10
    C07K 19/00
    C07K 16/00
    C40B 40/10
    C40B 50/06
    C40B 30/04
    A61P 31/18
  • US Classification:
    4241341, 5303871, 5303873, 5303917, 5303913, 4241601, 506 18, 506 26, 506 9
  • Abstract:
    The invention provides single domain antibodies and derivatives thereof that bind antigens of interest, which are stable, soluble, and do not tend to aggregate. The invention also provides methods for constructing a dAb library and methods for screening dAb libraries to identify the dAb of the invention. The invention also provide methods of treating or preventing conditions by antigen neutralization by administering the dAbs of the invention.

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