Weizao E Chen from 9378 Penrose St, Frederick, MD 21704, age 45

Human Domain Antibodies Against Components Of The Human Insulin-Like Growth Factor (Igf) System
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US Patent:

20120195897, Aug 2, 2012
Filed:

Oct 7, 2010
Appl. No.:

13/499758
Inventors:

Dimiter S. Dimitrov - Frederick MD, US
Weizao Chen - Frederick MD, US
International Classification:

A61K 39/395
C07K 16/28
C07K 16/46
C07K 19/00
C12N 15/13
C12N 15/62
C12N 1/21
C12N 1/19
C12N 5/10
A61K 31/7088
A61P 35/00
C12P 21/02
C12N 15/63
G01N 33/566
C07K 16/22
US Classification:

4241341, 5303873, 5303911, 5303913, 5303917, 536 2353, 536 234, 4241331, 43525233, 43525231, 4352523, 43525234, 43525421, 435328, 4241781, 514 44 R, 435 696, 4353201, 436501, 435 71
Abstract:

The invention provides antibodies or antibody fragments that bind to insulin-like growth factor (IGF) 1 receptor (IGF-1R) or IGF-2, as well as method of using the antibodies for inhibiting the IGF-mediated signaling pathway, inhibiting IGF-1R signaling, and treating cancer. The invention also provides a method of detecting the presence of IGF-1R or IGF-2 in a sample using the inventive antibodies and antibody fragments.

High-Affinity Fully Functional Soluble Single-Domain Human Cd4, Antibodies, And Related Fusion Proteins
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US Patent:

20130108636, May 2, 2013
Filed:

May 20, 2011
Appl. No.:

13/699535
Inventors:

Dimiter S. Dimitrov - Frederick MD, US
Weizao Chen - Frederick MD, US
International Classification:

C07K 16/10
US Classification:

4241341, 5303875, 4241371, 536 2353, 5303873, 4353201, 514 44 R
Abstract:

The invention provides engineered antibody domains (eAds), a polypeptide comprising a single domain CD4, as well as a fusion protein comprising the same. Nucleic acids encoding eAd and/or polypeptide or the fusion protein thereof, as well as compositions or cells comprising the eAd, polypeptide, fusion protein, or nucleic acid also are provided.

Anti-Hiv Domain Antibodies And Method Of Making And Using Same
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US Patent:

20110104163, May 5, 2011
Filed:

Jan 7, 2009
Appl. No.:

12/811998
Inventors:

Dimiter S. Dimitrov - Frederick MD, US
Weizao Chen - Frederick MD, US
Assignee:

THE UNITED STATES OF AMERICA, AS REPRESENTED BY TH - ROCKVILLE MD
International Classification:

A61K 39/42
C07K 16/10
C07K 19/00
C07K 16/00
C40B 40/10
C40B 50/06
C40B 30/04
A61P 31/18
US Classification:

4241341, 5303871, 5303873, 5303917, 5303913, 4241601, 506 18, 506 26, 506 9
Abstract:

The invention provides single domain antibodies and derivatives thereof that bind antigens of interest, which are stable, soluble, and do not tend to aggregate. The invention also provides methods for constructing a dAb library and methods for screening dAb libraries to identify the dAb of the invention. The invention also provide methods of treating or preventing conditions by antigen neutralization by administering the dAbs of the invention.

Human Monoclonal Antibodies Specific For Flt3 And Uses Thereof
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US Patent:

20190352408, Nov 21, 2019
Filed:

Dec 21, 2017
Appl. No.:

16/471485
Inventors:

- Bethesda MD, US
Weizao Chen - Frederick MD, US
Terry J. Fry - Aurora CO, US
Christopher Chien - Falls Church VA, US
Assignee:

The U.S.A., as represented by the Secretary, Department of Health and Human Services - Bethesda MD
International Classification:

C07K 16/28
C07K 14/705
C07K 14/725
A61K 47/68
C07K 16/46
A61K 47/69
A61P 35/00
A61P 35/04
A61P 35/02
G01N 33/577
Abstract:

Human monoclonal antibodies that specifically bind Fms-like tyrosine kinase 3 (FLT3) are described. Chimeric antigen receptors (CARs) and other antibody conjugates that include the FLT3-specific monoclonal antibodies are also described. Methods for the diagnosis and treatment of FLT3-associated cancer, such as acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML), are further described.

Stabilized Single Human Cd4 Domains And Fusion Proteins
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US Patent:

20180086812, Mar 29, 2018
Filed:

Oct 16, 2017
Appl. No.:

15/784988
Inventors:

- Bethesda MD, US
Weizao Chen - Frederick MD, US
Prabakaran Ponraj - Frederick MD, US
Assignee:

The United States of America, as represented by the Secretary, Department of Health and Human Serv - Bethesda MD
International Classification:

C07K 14/73
C07K 16/10
A61K 38/16
Abstract:

The invention provides a polypeptide comprising a single domain CD4, as well as a fusion protein comprising the single domain CD4 and one or more fusion partners. A nucleic acid encoding the polypeptide or fusion protein, as well as compositions or cells comprising the polypeptide, fusion protein, or nucleic acid also are provided.

Anti-Hiv Domain Antibodies And Method Of Making And Using Same
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US Patent:

20160207985, Jul 21, 2016
Filed:

Sep 28, 2015
Appl. No.:

14/867793
Inventors:

- Rockville MD, US
Weizao Chen - Frederick MD, US
International Classification:

C07K 16/10
C07K 14/73
A61K 47/48
A61K 39/42
A61K 38/17
Abstract:

The invention provides single domain antibodies and derivatives thereof that bind antigens of interest, which are stable, soluble, and do not tend to aggregate. The invention also provides methods for constructing a dAb library and methods for screening dAb libraries to identify the dAb of the invention. The invention also provide methods of treating or preventing conditions by antigen neutralization by administering the dAbs of the invention.

Stabilized Single Human Cd4 Domains And Fusion Proteins
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US Patent:

20160039904, Feb 11, 2016
Filed:

Mar 12, 2014
Appl. No.:

14/777245
Inventors:

- Bethesda MD, US
Weizao Chen - Frederick MD, US
Prabakaran Ponraj - Frederick MD, US
International Classification:

C07K 14/73
A61K 47/48
C07K 16/10
Abstract:

The invention provides a polypeptide comprising a single domain CD4, as well a fusion protein comprising the single domain CD4 and one or more fusion partners. A nucleic acid encoding the polypeptide or fusion protein, as well as compositions or cells comprising the polypeptide, fusion protein, or nucleic acid also are provided.

Human Domain Antibodies Against Components Of The Human Insulin-Like Growth Factor (Igf) System
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US Patent:

20150246967, Sep 3, 2015
Filed:

May 13, 2015
Appl. No.:

14/710875
Inventors:

- Bethesda MD, US
Weizao Chen - Frederick MD, US
Assignee:

The United States of America, as represented by the Secretary, Dept. of Health & Human Services - Bethesda MD
International Classification:

C07K 16/22
G01N 33/74
Abstract:

Antibodies and antibody fragments that bind to insulin-like growth factor (IGF) 1 receptor (IGF-1R) or IGF-2, as well as methods of using the antibodies for inhibiting the IGF-mediated signaling pathway, inhibiting IGF-1R signaling, and treating cancer, are described. A method of detecting the presence of IGF-1R or IGF-2 in a sample using the disclosed antibodies and antibody fragments is also described.

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Location:

Frederick, MD

Work:

Chief Executive Officer

Weizao E Chen