Weiguo Liu

US Patent:

7371885, May 13, 2008

Filed:

Nov 12, 2004

Appl. No.:

10/578465

Inventors:

Weiguo Liu - Parsippany NJ, US
Philip Harrington - Bad Dürkheim, DE

Assignee:

BASF Aktiengesellschaft - Ludwigshafen

International Classification:

C07C 281/14
C07B 57/00

US Classification:

558417, 564 36

Abstract:

The present invention relates to the isomerization of the Z-isomer I-Z of semicarbazone compounds of the general formula (I) into its E-isomer I-E, where the variables in formula (I) have meanings given in claim.

US Patent:

7442808, Oct 28, 2008

Filed:

May 11, 2007

Appl. No.:

11/801841

Inventors:

Min Ge - Edison NJ, US
Jiafang He - Dayton NJ, US
Fiona Wai Yu Lau - Edgewater NJ, US
Songnian Lin - Monroe NJ, US
Weiguo Liu - Princeton NJ, US
Shawn P. Walsh - Bridgewater NJ, US
Lihu Yang - Edison NJ, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07D 495/00
C07D 307/92
C07D 209/94
C07D 209/00
C07C 229/00
C07C 62/00
A61K 31/38
A61K 31/34
A61K 31/19
A61K 31/195
A61K 31/40

US Classification:

549 44, 549458, 548439, 548448, 562452, 562466, 514443, 514468, 514411, 514569, 514567

Abstract:

Tricyclic compounds containing a cyclopropyl carboxylic acid or carboxylic acid derivative (e. g. amide) fused to a bicyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

US Patent:

7476752, Jan 13, 2009

Filed:

Jun 9, 2005

Appl. No.:

11/148502

Inventors:

Weiguo Liu - Parsippany NJ, US
John L. Considine - Bridgewater NJ, US
Zhixian Ding - Fort Lee NJ, US
John Potoski - West Nyack NY, US

Assignee:

Wyeth - Madison NJ

International Classification:

C07C 253/30

US Classification:

558357

Abstract:

The present invention provides processes for the preparation of compounds of Formula I, which are useful in the preparation of pharmaceuticals for the treatment of inflammatory diseases. The compounds of Formula I are also useful as pharmaceuticals.

US Patent:

8399507, Mar 19, 2013

Filed:

Oct 27, 2008

Appl. No.:

12/738857

Inventors:

Xibin Liao - Edison NJ, US
Weiguo Liu - Princeton NJ, US
Paul E. Finke - Milltown NJ, US
Dooseop Kim - Westfield NJ, US
Lihu Yang - Edison NJ, US
Songnian Lin - Monroe NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 31/38
A61K 31/34
C07D 305/00
C07C 62/00

US Classification:

514443, 514468, 514411, 514469, 514597, 549510, 562452, 562466, 562506, 562508, 562510

Abstract:

Tricyclic compounds containing a cyclopropanecarboxylic acid fused to a bicyclic ring, including pharmaceutically acceptable salts, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

US Patent:

20050277784, Dec 15, 2005

Filed:

Jun 9, 2005

Appl. No.:

11/148603

Inventors:

Weiguo Liu - Parsippany NJ, US
John Considine - Bridgewater NJ, US
Zhixian Ding - Fort Lee NJ, US
John Potoski - West Nyack NY, US

Assignee:

Wyeth - Madison NJ

International Classification:

C07C253/30

US Classification:

558357000

Abstract:

The present invention provides processes for the preparation of compounds of Formula III that are useful in the preparation of pharmaceuticals for the treatment of inflammatory diseases.

US Patent:

20070265335, Nov 15, 2007

Filed:

Nov 9, 2006

Appl. No.:

11/558382

Inventors:

WEIGUO LIU - PARSIPPANY NJ, US
QIUXIA WANG - NANUET NY, US
WEI TONG - SUFFERN NY, US
PANOLIL RAVEENDRANATH - MONROE NY, US
SILVIO IERA - MONTREAL, CA

Assignee:

WYETH - Madison NJ
VIROPHARMA INCORPORATED - Exton PA

International Classification:

A61K 31/343
A61P 31/14
C07D 307/78

US Classification:

514469000, 549467000

Abstract:

Substantially pure polymorphic forms of 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-N-methyl-1-benzofuran-3-carboxamide are produced by recrystallization in an organic solvent.

US Patent:

20080058523, Mar 6, 2008

Filed:

Jun 7, 2007

Appl. No.:

11/811328

Inventors:

Weiguo Liu - Parsippany NJ, US
Vladimir Dragan - Chester NY, US
Henry Strong - Somerset NJ, US
Yanzhong Wu - Bardonia NY, US
Zhixin Wen - Nanuet NY, US
Jessica Liang - Annandale NJ, US
Haris Durutlic - New Windsor NY, US
Karen Sutherland - New City NY, US
Anthony Pilcher - Colchester VT, US

International Classification:

C07D 401/10
C07D 401/14

US Classification:

544363000

Abstract:

The present invention relates to processes for synthesizing piperazine-piperidine compounds, and compounds useful as 5-HTbinding agents, particularly as 5-HTreceptor antagonists and agonists. The processes also allow for safer and environmentally tolerant production of these useful compounds.

US Patent:

20110207737, Aug 25, 2011

Filed:

Nov 11, 2009

Appl. No.:

13/125088

Inventors:

Jiafang He - Dayton NJ, US
John Bawiec - Wilkes-Barre PA, US
Weiguo Liu - Princeton NJ, US
Lihu Yang - Edison NJ, US

International Classification:

A61K 31/498
C07D 413/12
A61K 31/423
A61P 3/10
A61P 3/04
A61P 3/06
A61P 9/10
C07D 401/12
A61K 31/4439
C07D 417/12
A61K 31/428
A61K 31/4709
C07D 209/52
A61K 31/403
C07D 403/12
A61K 31/497
A61K 31/501
A61K 31/502

US Classification:

514249, 548222, 514375, 5462767, 514339, 548159, 514367, 546156, 514312, 514314, 546169, 548452, 514412, 544406, 51425505, 544238, 51425206, 544235, 514248

Abstract:

Described herein are substituted bicyclic amines. In particular, described herein are substituted bicyclic amines that are effective as antagonists of SSTR5 and useful for the treatment, control or prevention of disorders responsive to antagonism of SSTR5, such as type 2 diabetes, insulin resistance, lipid disorders, obesity, atherosclerosis, metabolic syndrome, depression, and anxiety.

Author:

Weiguo Liu

ISBN #:

7220058098