Thomas R Buelter from Santa Monica, CA, age 56

Us Patents

Reduced By-Product Accumulation For Improved Production Of Isobutanol
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US Patent:

8133715, Mar 13, 2012
Filed:

Mar 29, 2011
Appl. No.:

13/074907
Inventors:

Thomas Buelter - Denver CO, US
Andrew Hawkins - Parker CO, US
Peter Meinhold - Denver CO, US
Catherine Asleson Dundon - Englewood CO, US
Aristos Aristidou - Highlands Ranch CO, US
Jun Urano - Aurora CO, US
Matthew Peters - Highlands Ranch CO, US
Melissa Dey - Aurora CO, US
Justas Jancauskas - Englewood CO, US
Julie Kelly - Denver CO, US
Ruth Berry - Englewood CO, US
Assignee:

Gevo, Inc. - Englewood CO
International Classification:

C12N 1/00
C12N 15/00
C12N 15/87
C12N 15/74
C12P 7/16
C12P 1/00
C07H 21/04
C07K 1/00
US Classification:

43525411, 4352542, 43525421, 43525422, 43525423, 435160, 435 41, 435440, 435463, 435471, 435476, 435483, 536 231, 536 232, 536 237, 536 2374, 530350
Abstract:

The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In various aspects of the invention, the recombinant microorganisms may further comprise one or more modifications resulting in the reduction or elimination of 3 keto-acid (e. g. , acetolactate and 2-aceto-2-hydroxybutyrate) and/or aldehyde-derived by-products. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.

Reduced By-Product Accumulation For Improved Production Of Isobutanol
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US Patent:

8153415, Apr 10, 2012
Filed:

Mar 31, 2011
Appl. No.:

13/077170
Inventors:

Thomas Buelter - Denver CO, US
Andrew Hawkins - Parker CO, US
Peter Meinhold - Denver CO, US
Catherine Asleson Dundon - Englewood CO, US
Aristos Aristidou - Highlands Ranch CO, US
Jun Urano - Aurora CO, US
Doug Lies - Parker CO, US
Matthew Peters - Highland Ranch CO, US
Melissa Dey - Aurora CO, US
Justas Jancauskas - Englewood CO, US
Julie Kelly - Denver CO, US
Ruth Berry - Englewood CO, US
Assignee:

Gevo, Inc. - Englewood CO
International Classification:

C12N 1/00
C12N 15/00
C12N 15/87
C12N 15/74
C12P 7/16
C12P 1/00
C07H 21/04
C07K 1/00
US Classification:

43525411, 4352542, 43525421, 43525422, 43525423, 435160, 435 41, 435440, 435463, 435471, 435476, 536 231, 536 232, 536 237, 536 2374, 530350
Abstract:

The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In various aspects of the invention, the recombinant microorganisms may further comprise one or more modifications resulting in the reduction or elimination of 3 keto-acid (e. g. , acetolactate and 2-aceto-2-hydroxybutyrate) and/or aldehyde-derived by-products. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.

Methods For The Economical Production Of Biofuel From Biomass
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US Patent:

8431374, Apr 30, 2013
Filed:

Oct 31, 2008
Appl. No.:

12/263436
Inventors:

Andrew C. Hawkins - Parker CO, US
David A. Glassner - Littleton CO, US
Thomas Buelter - Denver CO, US
James Wade - San Diego CA, US
Peter Meinhold - Denver CO, US
Matthew W. Peters - Highlands Ranch CO, US
Patrick R. Gruber - Longmont CO, US
William A. Evanko - Golden CO, US
Aristos A. Aristidou - Highlands Ranch CO, US
Marco Landwehr - Magdeburg, DE
Assignee:

Gevo, Inc. - Englewood CO
International Classification:

C12P 7/16
C12N 1/21
C07H 21/04
US Classification:

435160, 4352523, 43525233, 536 231
Abstract:

Methods for producing a biofuel are provided. Also provided are biocatalysts that convert a feedstock to a biofuel.

Engineered Microorganisms For Increasing Product Yield In Biotransformations, Related Methods And Systems
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US Patent:

20080293101, Nov 27, 2008
Filed:

Jul 27, 2007
Appl. No.:

11/881748
Inventors:

Matthew W. Peters - Highlands Ranch CO, US
Peter Meinhold - Highlands Ranch CO, US
Thomas Buelter - Santa Monica CA, US
Marco Landwehr - Pasadena CA, US
International Classification:

C12P 21/04
C12N 1/20
C12P 7/04
C12M 1/00
US Classification:

435 691, 4352523, 43525233, 435157, 4352891
Abstract:

There are disclosed recombinant microorganisms engineered to increase product yield in a biotransformation. In an embodiment, the microorganisms are engineered to increase the amount of NAD(P)H available for a NAD(P)H-requiring oxidoreductase involved in a biotransformation. There are also disclosed methods and systems for using recombinant microorganisms engineered to increase the amount of NAD(P)H available for a NAD(P)H-requiring oxidoreductase involved in a biotransformation. Other embodiments are also disclosed.

Engineered Microorganisms For Producing Isopropanol
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US Patent:

20080293125, Nov 27, 2008
Filed:

Apr 18, 2008
Appl. No.:

12/106173
Inventors:

Ezhilkani Subbian - Mountain View CA, US
Peter Meinhold - Highlands Ranch CO, US
Thomas Buelter - Denver CO, US
Andrew C. Hawkins - Parker CO, US
Assignee:

Gevo, Inc. - Centennal CO
International Classification:

C07C 31/10
C12N 1/21
C12N 1/15
C12P 7/04
C12N 1/19
US Classification:

4352523, 43525411, 4352542, 43525233, 43525421, 43525422, 43525423, 4352543, 43525231, 43525232, 43525234, 43525235, 568840, 435157
Abstract:

In an embodiment, there is disclosed a recombinant microbial host cell having each of the DNA molecules encoding a polypeptide or group of polypeptides that catalyze the conversion:wherein at least one DNA molecule is heterologous to the microbial host cell and wherein the microbial host cell produces isopropanol. In another embodiment, a method is disclosed for the production of isopropanol including providing a recombinant microbial host cell, the host cell of (i) with a fermentable carbon substrate in a fermentation medium under conditions whereby isopropanol is produced, and recovering the isopropanol.

Engineered Microorganisms For Producing N-Butanol And Related Methods
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US Patent:

20090155869, Jun 18, 2009
Filed:

Dec 3, 2007
Appl. No.:

11/949724
Inventors:

Thomas Buelter - Santa Monica CA, US
Andrew C. Hawkins - Pasadena CA, US
Kalib Kersh - LaVerne CA, US
Peter Meinhold - Pasadena CA, US
Matthew W. Peters - Pasadena CA, US
Ezhilkani Subbian - Pasadena CA, US
Assignee:

Gevo, Inc. - Pasadena CA
International Classification:

C12P 7/16
C12N 1/21
US Classification:

435160, 4352523
Abstract:

A recombinant microorganism expressing at least a heterologous enzyme of an NADH-dependent pathway for conversion of a carbon source to n-butanol, metabolic intermediate and/or a derivative thereof and capable of producing n-butanol, a metabolic intermediate and/or a derivative thereof at a high yield and related methods. The recombinant microorganism engineered to inactivate a native enzyme of one or more pathways that compete with NADH-dependent heterologous pathway, and/or to balance the NADH-dependent heterologous pathway with respect to NADH production and consumption.

Methods For The Economical Production Of Biofuel Precursor That Is Also A Biofuel From Biomass
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US Patent:

20090215137, Aug 27, 2009
Filed:

Oct 31, 2008
Appl. No.:

12/263442
Inventors:

Andrew C. Hawkins - Parker CO, US
David A. Glassner - Littleton CO, US
Thomas Buelter - Denver CO, US
James Wade - San Diego CA, US
Peter Meinhold - Denver CO, US
Matthew W. Peters - Highlands Ranch CO, US
Patrick R. Gruber - Longmont CO, US
William A. Evanko - Golden CO, US
Aristos A. Aristidou - Highlands Ranch CO, US
Assignee:

GEVO, INC. - ENGLEWOOD CO
International Classification:

C12P 7/16
C12P 1/00
C12N 1/21
US Classification:

435160, 435 41, 4352523
Abstract:

Methods for producing a biofuel precursor are provided. Also provided are biocatalysts that convert a feedstock to a biofuel precursor.

Engineered Microorganisms For Producing Propanol
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US Patent:

20090246842, Oct 1, 2009
Filed:

Feb 13, 2009
Appl. No.:

12/371557
Inventors:

Andrew C. HAWKINS - Parker CO, US
Matthew W. PETERS - Highlands Ranch CO, US
Peter MEINHOLD - Denver CO, US
Thomas BUELTER - Denver CO, US
David A. GLASSNER - Littleton CO, US
Patrick R. GRUBER - Longmont CO, US
James WADE - San Diego CA, US
Assignee:

GEVO, INC. - Englewood CO
International Classification:

C12P 7/04
C12P 1/00
C12P 5/02
C12P 1/02
US Classification:

435157, 435 41, 435167, 435171
Abstract:

Methods and compositions for the production of bio-based material precursors are provided.