Tej B Shrestha

US Patent:

20130243741, Sep 19, 2013

Filed:

Sep 19, 2011

Appl. No.:

13/821516

Inventors:

Stefan H. Bossmann - Manhattan KS, US
Deryl L. Troyer - Manhattan KS, US
Matthew T. Basel - Manhattan KS, US
Tej B. Shrestha - Manhattan KS, US
Hongwang Wang - Manhattan KS, US

Assignee:

KANSAS STATE UNIVERSITY RESEARCH FOUNDATION - Manhattan KS

International Classification:

A61K 41/00

US Classification:

424 9321

Abstract:

A method for photodynamic therapy treatment of cancerous cells and tissue is provided. The method comprises administering tumor-trophic cells expressing a luminescent protein to a subject. A photosensitizing agent is then separately administered to the subject, followed by an optional iron chelator. On the day of treatment, a luminogenic substrate corresponding to the luminescent protein is administered to the subject. The substrate reacts with the luminescent protein in the vicinity of the cancerous tissue to produce light which activates the photosensitizing agent resulting in the selective destruction of the cancerous tissue.

US Patent:

20130183702, Jul 18, 2013

Filed:

Mar 13, 2013

Appl. No.:

13/800456

Inventors:

Kansas State University Research Foundation - Manhattan KS, US
Deryl L. Troyer - Manhattan KS, US
Matthew T. Basel - Manhattan KS, US
Tej B. Shrestha - Manhattan KS, US
Hongwang Wang - Manhattan KS, US

Assignee:

Kansas State University Research Foundation - Manhattan KS

International Classification:

C12Q 1/37
A61K 9/127
C12N 11/06

US Classification:

435 23, 435183, 435181

Abstract:

Supramolecular assemblies for delivering active agents to cancerous or precancerous tissues in a subject are provided. These supramolecular assemblies are also useful in assays for detecting and imaging of cancerous and precancerous cells. The assemblies are protease-sensitive and comprise a peptide linkage containing a protease consensus sequence. The assemblies can be selectively targeted to cancerous tissue where the protease enzymes degrade the peptide linkage thereby releasing the active agents which were physically or mechanically contained in or retained by the supramolecular assembly.

US Patent:

20150224211, Aug 13, 2015

Filed:

Apr 23, 2015

Appl. No.:

14/694511

Inventors:

Deryl L. Troyer - , US
Stefan H. Bossmann - , US
Hongwang Wang - Manhattan KS, US
Matthew T. Basel - Manhattan KS, US
Tej B. Shrestha - Manhattan KS, US
Sebastian Wendel - Manhattan KS, US

International Classification:

A61K 49/00
A61K 9/127
A61K 47/46
A61K 41/00
A61K 31/65

Abstract:

Theranostic methods are described herein, which are useful in diagnosing and/or treating infection, inflammation, and/or cancer. The methods utilize naturally-occurring leukocytes for in situ photodynamic therapy and imaging, and for the delivery of targeted therapies to the infection, inflammation, and/or cancer.

US Patent:

20150141238, May 21, 2015

Filed:

Jan 23, 2015

Appl. No.:

14/603628

Inventors:

- Manhattan KS, US
Stefan H. Bossmann - Manhattan KS, US
Donghai Wang - Manhattan KS, US
Deryl L. Troyer - Manhattan KS, US
Tej Shrestha - Manhattan KS, US

International Classification:

B01J 35/02
C10L 1/04
C07C 1/12
B01J 29/10
B01J 21/04
C07C 1/22
B01J 23/745

US Classification:

502 74, 585469, 422211, 502338, 518719

Abstract:

Nanocatalysts and methods of using the same to obtain aromatic hydrocarbon compounds from a source of carbon atoms and a source of hydrogen atoms in a single reaction step is provided. The catalyst comprises an Fe/FeOnanocatalyst that may be supported on a non-reactive support material such as a zeolite or alumina COand Hare preferred sources of carbon and hydrogen atoms for the reaction. The aromatic hydrocarbon compounds produced are suitable for direct usage as fuel without need for further refining.