Susan Woulfe - Woodbury MN, US Rita Jain - Roslyn Harbor NY, US Aimee Burr - Chicago IL, US
International Classification:
A61K039/395 A61K031/525
US Classification:
424145100, 514251000
Abstract:
The present invention provides a combination therapeutic composition useful in modulating, treating and/or preventing inflammatory diseases. The therapeutic composition includes antibody Fab′ fragment CDP870 that is specific for antigenic determinants of tumor necrosis factor alpha and at least one Disease Modifying Anti-Rheumatic Disease drug such as methotrexate or sulfasalazine. The therapeutic composition can be administered to either a human or animal subject in single or multiple doses over time in the treatment of rheumatoid arthritis, Crohn's Disease or any other inflammatory disease.
- St. Paul MN, US Gilles J. Benoit - Minneapolis MN, US Peter O. Olson - Andover MN, US Tyler W. Olson - Woodbury MN, US Himanshu Nayar - St. Paul MN, US Frederick J. Arsenault - Stillwater MN, US Nicholas A. Johnson - Burnsville MN, US Susan L. Woulfe - Woodbury MN, US Mark A. Tomai - Hudson WI, US
Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for selecting settings for a treatment of a patient. In one aspect, the method comprises repeatedly performing the following: i) selecting a configuration of input settings for providing a treatment to a patient based on a causal model that measures current causal relationships between input settings and effects of treatments on the patient; ii) receiving a measure of an effect of the treatment on the patient; and iii) adjusting, based on the measure of the effect of the treatment on the patient, the causal model.
Manufacturing A Biologic Pharmaceutical Using Causal Models
- St. Paul MN, US Gilles J. Benoit - Minneapolis MN, US Peter O. Olson - Andover MN, US Tyler W. Olson - Woodbury MN, US Himanshu Nayar - St. Paul MN, US Frederick J. Arsenault - Stillwater MN, US Nicholas A. Johnson - Woodbury MN, US Susan L. Woulfe - Woodbury MN, US Mark A. Tomai - Hudson WI, US
International Classification:
G01N 33/15 G05B 13/04 B01J 19/00
Abstract:
Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for optimizing a process of manufacturing a biologic pharmaceutical. In one aspect, the method comprises repeatedly performing the following: i) selecting a configuration of input settings for manufacturing a batch of a biologic pharmaceutical based on a causal model that measures current causal relationships between input settings and a measure of a quality of batches of the biological pharmaceutical; ii) determining a measure of the quality of a batch of the biological pharmaceutical manufactured using the configuration of input settings; and iii) adjusting, based on the measure of the quality of the batch of the biological pharmaceutical, the causal model.
- St. Paul MN, US Gilles J. Benoit - Minneapolis MN, US Peter O. Olson - Andover MN, US Tyler W. Olson - Woodbury MN, US Himanshu Nayar - St. Paul MN, US Frederick J. Arsenault - Stillwater MN, US Nicholas A. Johnson - Woodbury MN, US Susan L. Woulfe - Woodbury MN, US Mark A. Tomai - Hudson WI, US
International Classification:
G16H 10/20 G16H 50/70
Abstract:
Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for designing a clinical trial. In one aspect, the method comprises repeatedly performing the following: i) selecting, from a population of patients, patients for being treated with the treatment using a configuration of input settings, wherein the configuration is selected based on a causal model that measures current causal relationships between input settings and a measure of success of the clinical trial; ii) determining the measure of success of the clinical trial for which patients were selected using the certain configuration of input settings; and iii) adjusting, based on the measure of success of the clinical trial, the causal model.