Sergio G Duron

US Patent:

7517884, Apr 14, 2009

Filed:

May 16, 2006

Appl. No.:

11/435082

Inventors:

James W. Malecha - San Diego CA, US
Sergio G. Duron - San Diego CA, US
Andrew K. Lindstrom - Encinitas CA, US

Assignee:

Kalypsys Inc. - San Diego CA

International Classification:

A61K 31/4965
C07D 241/04

US Classification:

51425502, 51425503, 544383, 544392, 544403

Abstract:

Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.

US Patent:

7834004, Nov 16, 2010

Filed:

Sep 4, 2008

Appl. No.:

12/204489

Inventors:

Stewart A. Noble - San Diego CA, US
Guy Oshiro - San Diego CA, US
James W. Malecha - San Diego CA, US
Cunxiang Zhao - San Diego CA, US
Carmen Robinson - San Diego CA, US
Sergio G. Duron - San Diego CA, US
Michael Sertic - Del Mar CA, US
Andrew K. Lindstrom - Encinitas CA, US
Andrew K. Shiau - San Diego CA, US
Christopher D Bayne - Honolulu HI, US
Mehmet Kahraman - San Diego CA, US
Boliang Lou - Louisville KY, US
Steven P. Govek - San Diego CA, US

Assignee:

Kalypsys, Inc - San Diego CA

International Classification:

A61K 31/496
A61K 31/343
A61K 31/404
A61K 31/551
A61K 31/495
C07D 333/52
C07D 403/02
C07D 209/04
C07D 405/02
C07D 307/78

US Classification:

514218, 51425213, 514414, 514415, 514443, 514469, 51425502, 51425301, 51425409, 544359, 544373, 544360, 548465, 548469, 549 49, 549462

Abstract:

Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.

US Patent:

7915253, Mar 29, 2011

Filed:

Sep 4, 2008

Appl. No.:

12/204459

Inventors:

Stewart A. Noble - San Diego CA, US
Guy Oshiro - San Diego CA, US
James W. Malecha - San Diego CA, US
Cunxiang Zhao - San Diego CA, US
Carmen K. Robinson - San Diego CA, US
Sergio G. Duron - San Diego CA, US
Michael Sertic - San Diego CA, US
Andrew K. Lindstrom - Endinitas CA, US
Andrew K. Shiau - San Diego CA, US
Christopher D. Bayne - Honolulu HI, US
Mehmet Kahraman - San Diego CA, US
Boliang Lou - Louisville KY, US
Steve P. Govek - San Diego CA, US

Assignee:

Kalypsys, Inc - San Diego CA

International Classification:

A61K 31/496
A61K 31/4418
A61K 31/551
A61K 31/495
C07D 241/04
C07D 401/04
C07D 211/70
C07D 401/12
C07D 409/14

US Classification:

514218, 51425213, 51425503, 51425301, 514277, 51425409, 51425311, 544383, 544360, 544373, 544364, 544376, 546313

Abstract:

Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.

US Patent:

8399018, Mar 19, 2013

Filed:

Jul 21, 2009

Appl. No.:

12/506664

Inventors:

Jay Lichter - Rancho Santa Fe CA, US
Benedikt Vollrath - San Diego CA, US
Sergio G. Duron - San Diego CA, US
Carl Lebel - Malibu CA, US
Fabrice Piu - San Diego CA, US
Qiang Ye - San Diego CA, US
Luis A. Dellamary - San Marcos CA, US
Andrew M. Trammel - Olathe KS, US
Michael Christopher Scaife - Los Altos CA, US
Jeffrey P. Harris - La Jolla CA, US

Assignee:

Otonomy, Inc. - San Diego CA
The Regents of The University of California - Oakland CA

International Classification:

A61K 9/14

US Classification:

424484

Abstract:

Disclosed herein are compositions and methods for the treatment of otic disorders with ion channel modulators. In these methods, the ion channel modulator compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the ion channel modulator compositions and formulations onto the auris interna target areas, or via perfusion into the auris interna structures.

US Patent:

8496957, Jul 30, 2013

Filed:

Jul 16, 2009

Appl. No.:

12/504553

Inventors:

Jay Lichter - Rancho Santa Fe CA, US
Benedikt Vollrath - San Diego CA, US
Sergio G. Duron - San Diego CA, US
Carl Lebel - Malibu CA, US
Fabrice Piu - San Diego CA, US
Qiang Ye - San Diego CA, US
Luis A. Dellamary - San Marcos CA, US
Andrew M. Trammel - Olathe KS, US
Michael Christopher Scaife - Los Altos CA, US
Jeffrey P. Harris - La Jolla CA, US

Assignee:

Otonomy, Inc - San Diego CA
The Regents of the University of California - Oakland CA

International Classification:

A61K 9/14
A61K 31/47
A61K 31/517

US Classification:

424437, 424489, 5142661, 514312, 514646

Abstract:

Disclosed herein are methods for the treatment of otic diseases or conditions with intratympanic compositions and formulations of multiparticulate auris sensory cell modulating agent administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).

US Patent:

20050203151, Sep 15, 2005

Filed:

Dec 20, 2004

Appl. No.:

11/019146

Inventors:

James Malecha - San Diego CA, US
Cunxiang Zhao - San Diego CA, US
Carmen Robinson - San Diego CA, US
Sergio Duron - San Diego CA, US
Michael Sertic - Del Mar CA, US
Stewart Noble - San Diego CA, US

Assignee:

Kalypsys, Inc. - San Diego CA

International Classification:

A61K031/427
C07D417/02

US Classification:

514365000, 548181000

Abstract:

Described herein are novel mono- and bicyclic compounds compounds, including compounds capable of modulating the activity of human peroxisome proliferator activated receptor of the subtype delta (hPPAR-delta), and methods for utilizing such modulation to treat a disease or condition mediated or impacted by hPPAR-delta activity such as Type 2 diabetes, syndrome X, dyslipidemia, and atherosclerotic diseases including vascular disease, coronary heart disease, cerebrovascular disease, and peripheral vessel disease. Also described are compounds that mediate and/or inhibit the activity of hPPAR-delta, and pharmaceutical compositions containing such compounds or pharmaceutically acceptable prodrugs, solvates, salts, esters, thioesters, or amides or pharmaceutically active metabolites thereof. Further described are methods for making and producing such compounds. Also described are the therapeutic or prophylactic use of such compounds or compositions, and methods of treating metabolic disorders and conditions, by administering effective amounts of such compounds.

US Patent:

20050234046, Oct 20, 2005

Filed:

Apr 7, 2005

Appl. No.:

11/102356

Inventors:

Cunxiang Zhao - San Diego CA, US
James Malecha - San Diego CA, US
Stewart Noble - San Diego CA, US
Sergio Duron - San Diego CA, US
Andrew Lindstrom - San Diego CA, US
Andrew Shiau - San Diego CA, US

Assignee:

Kalypsys, Inc. - San Diego CA

International Classification:

A61K031/551
A61K031/496
A61K031/495
A61K031/445
A61K031/407
C07D417/02
C07D043/04

US Classification:

514218000, 514253010, 514254020, 514412000, 514255020, 514317000, 514252140, 540575000, 544295000, 544360000, 544368000, 544383000, 546216000

Abstract:

Aryl sulfonamide and sulfonyl compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.

US Patent:

20060167012, Jul 27, 2006

Filed:

Oct 25, 2005

Appl. No.:

11/258463

Inventors:

Stewart Noble - San Diego CA, US
Guy Oshiro - San Diego CA, US
James Malecha - San Diego CA, US
Cunxiang Zhao - San Diego CA, US
Carmen Robinson - San Diego CA, US
Sergio Duron - San Diego CA, US
Michael Sertic - Del Mar CA, US
Andrew Lindstrom - Encinitas CA, US
Andrew Shiau - San Diego CA, US
Christopher Bayne - Honolulu HI, US
Mehmet Kahraman - San Diego CA, US
Boliang Lou - Louisville KY, US
Steven Govek - San Diego CA, US

International Classification:

A61K 31/495
A61K 31/4439
A61K 31/44
C07D 403/02

US Classification:

514255020, 514345000, 544384000, 546290000, 514339000, 546277400

Abstract:

Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.