Pu V Chen from 11395 Pacific Shores Way, San Diego, CA 92130

Nucleic Acids, Kits And Methods For The Diagnosis, Prognosis And Treatment Of Glaucoma And Related Disorders
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US Patent:

7138511, Nov 21, 2006
Filed:

Jan 11, 1999
Appl. No.:

09/227881
Inventors:

Thai D. Nguyen - Mill Valley CA, US
Jon R. Polansky - Mill Valley CA, US
Pu Chen - San Diego CA, US
Hua Chen - San Francisco CA, US
Assignee:

The Regents of the University of California - Oakland CA
International Classification:

C07H 21/04
A61K 48/00
C12Q 1/68
US Classification:

536 235, 536 231, 536 245, 514 44, 435 6, 435325, 435375
Abstract:

In a preferred aspect of the invention, the upstream sequences of the TIGR protein encoding sequence can be used to diagnose a sensivity to steroids and a risk for glaucoma or ocular hypertensive disorders. Methods, kits, and nucleic acids containing polymorphisms, base substitutions, or base additions located within the upstream region and within protein-encoding regions of the TIGR gene are also provided. The upstream sequences disclosed, including the TIGR promoter regions and those regions possessing functional characterisitics associated with or possesssed by the TIGR gene 5′regulatory region, can also be used to generate cells, vectors, and nucleic acids useful in a variety of diagnostic and prognostic methods and kits as well as therapeutic compounds, compositions, and methods.

Nucleic Acids, Kits, And Methods For The Diagnosis, Prognosis And Treatment Of Glaucoma And Related Disorders
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US Patent:

20030068640, Apr 10, 2003
Filed:

Sep 17, 2002
Appl. No.:

10/244633
Inventors:

Thai Nguyen - Mill Valley CA, US
Jon Polansky - Mill Valley CA, US
Pu Chen - San Diego CA, US
Hua Chen - San Francisco CA, US
International Classification:

C12Q001/68
US Classification:

435/006000
Abstract:

In a preferred aspect of the invention, the upstream sequences of the TIGR protein encoding sequence can be used to diagnose a sensivity to steroids and a risk for glaucoma or ocular hypertensive disorders. Methods, kits, and nucleic acids containing polymorphisms, base substitutions, or base additions located within the upstream region and within protein-encoding regions of the TIGR gene are also provided. The upstream sequences disclosed, including the TIGR promoter regions and those regions possessing functional characteristics associated with or possessed by the TIGR gene 5′regulatory region, can also be used to generate cells, vectors, transgenic animals, and nucleic acid constructs useful in a variety of diagnostic and prognostic methods and kits as well as therapeutic compounds, compositions, and methods.