Jasbir Singh - Naperville IL, US Mark E. Gurney - Grand Rapids MI, US Georgeta Hategan - Naperville IL, US Peng Yu - Lisle IL, US David Zembower - La Grange IL, US Nian Zhou - Naperville IL, US
Assignee:
deCODE genetics ehf - Reykjavik
International Classification:
C07D 411/00
US Classification:
548467
Abstract:
Acyl sulfonamide, peri-substituted, fused bicyclic ring compounds useful for the treatment or prophylaxis of a prostaglandin-mediated disease or condition are disclosed. The compounds are of the general formula.
Carboxylic Acid Peri-Substituted Bicyclics For Occlusive Artery Disease
Jasbir Singh - Naperville IL, US Mark Gurney - Grand Rapids MI, US Georgeta Hategan - Naperville IL, US Peng Yu - Lisle IL, US David Zembower - LaGrange IL, US Nian Zhou - Naperville IL, US Alexandre Mikhaylovich Polozov - Naperville IL, US Wayne Edward Zeller - Viroqua WI, US
Peri-substituted, fused bicyclic ring carboxylic acids useful for the treatment or prophylaxis of a prostaglandin-mediated disease or condition are disclosed. The compounds are of the general formula.
Biaryl Substituted Heterocycle Inhibitors Of Lta4H For Treating Inflammation
Vincent Sandanayaka - Woodridge IL, US Jasbir Singh - Woodridge IL, US Mark Gurney - Woodridge IL, US Bjorn Mamat - Woodridge IL, US Peng Yu - Woodridge IL, US Louis Bedell - Woodridge IL, US Lei Zhao - Woodridge IL, US
The present invention relates to a chemical genus of biaryl substituted heterocycle inhibitors of LTA4H (leukotriene A4 hydrolase) useful for the treatment and prevention and prophylaxis of inflammatory diseases and disorders. The compounds have general formula Ψ: An example is
Sulfonamide Peri-Substituted Bicyclics For Occlusive Artery Disease
Jasbir Singh - Naperville IL, US Mark E. Gurney - Grand Rapids MI, US Georgeta Hategan - Naperville IL, US Peng Yu - Lisle IL, US David Zembower - La Grange IL, US Nian Zhou - Naperville IL, US
Acyl sulfonamide, peri-substituted, fused bicyclic ring compounds useful for the treatment or prophylaxis of a prostaglandin-mediated disease or condition are disclosed. The compounds are of the general formulaA representative example is: