Paul B Yoo

US Patent:

8509919, Aug 13, 2013

Filed:

May 24, 2011

Appl. No.:

13/114626

Inventors:

Paul B. Yoo - Raleigh NC, US
Warren M. Grill - Chapel Hill NC, US
Juan Gabriel Hincapie Ordonez - Maple Grove MN, US

Assignee:

Cardiac Pacemakers, Inc. - St. Paul MN
Duke University - Durham NC

International Classification:

A61N 1/18

US Classification:

607118, 607 48

Abstract:

By targeting on selected branches or fascicles of a vagus nerve using electrode placement and/or selection, one or more target branches of the vagus nerve are substantially activated by electrical stimulation pulses delivered to a branch without substantially activating one or more non-target branches. In one embodiment, vagus nerve stimulation is delivered through an electrode placed on a thoracic vagus nerve that is separated from a recurrent laryngeal nerve, such that the vagus nerve is stimulated without causing laryngeal muscle contractions. In another embodiment, vagus nerve stimulation is delivered through a multi-contact electrode with one or more contacts selected for delivering the electrical stimulation pulses to stimulate the vagus nerve without causing laryngeal muscle contractions.

US Patent:

20060224211, Oct 5, 2006

Filed:

Apr 19, 2005

Appl. No.:

11/109338

Inventors:

Dominique Durand - Solon OH, US
Paul Yoo - Greensboro NC, US

International Classification:

A61N 1/36

US Classification:

607048000, 607042000, 607002000

Abstract:

A method for treating a medical condition, such as obstructive sleep apnea, includes the step of stimulating a nerve, particularly the hypoglossal nerve, using at least one of the following techniques: (a) continuous low-level electrical stimulation; (b) electrical stimulation synchronized with a physical process, such as inspiration, without feedback from the nerve being stimulated; and (c) intermittent electrical stimulation at controlled intervals based on the patient's metabolism.

US Patent:

20100131029, May 27, 2010

Filed:

Jan 29, 2010

Appl. No.:

12/696106

Inventors:

Dominique M. DURAND - Solon OH, US
Paul Byongsuk YOO - Durham NC, US

Assignee:

CASE WESTERN RESERVE UNIVERSITY - Cleveland OH

International Classification:

A61N 1/36

US Classification:

607 42

Abstract:

A method for treating a medical condition, such as obstructive sleep apnea, includes the step of stimulating a nerve, particularly the hypoglossal nerve, using at least one of the following techniques: (a) continuous low-level electrical stimulation; (b) electrical stimulation synchronized with a physical process, such as inspiration, without feedback from the nerve being stimulated; and (c) intermittent electrical stimulation at controlled intervals based on the patient's metabolism.

US Patent:

20110301659, Dec 8, 2011

Filed:

May 24, 2011

Appl. No.:

13/114686

Inventors:

Paul B. Yoo - Raleigh NC, US
Warren M. Grill - Chapel Hill NC, US
Juan Gabriel Hincapie Ordonez - Maple Grove MN, US

International Classification:

A61N 1/362
A61N 1/36

US Classification:

607 9, 607 72, 607 44

Abstract:

One or more temporal stimulation parameters of vagus nerve stimulation (VNS) are selected to substantially modulate one or more target physiological functions without substantially modulating one or more non-target physiological functions. In one embodiment, a stimulation duty cycle is selected such that VNS is delivered to the cervical vagus nerve trunk to modulate a cardiovascular function without causing laryngeal muscle contractions.