Paul W Wedeking

US Patent:

7186397, Mar 6, 2007

Filed:

Dec 30, 2000

Appl. No.:

09/752867

Inventors:

Paul W. Wedeking - Pennington NJ, US
Ruth E. Wager - Rockville MD, US
Thangavel Arunachalam - Plainsboro NJ, US
Karen E. Linder - Kingston NJ, US
Ramachandran S. Ranganathan - Princeton NJ, US
Adrian D. Nunn - Lambertville NJ, US
Natarajan Raju - Kendall Park NJ, US
Michael F. Tweedle - Princeton NJ, US

Assignee:

Bracco International B.V. - Amsterdam

International Classification:

A61K 51/00
A61M 36/14

US Classification:

424 173, 424 111, 424 91, 424 165

Abstract:

Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the α, γ, or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.

US Patent:

7399460, Jul 15, 2008

Filed:

Sep 25, 2006

Appl. No.:

11/534919

Inventors:

Paul W. Wedeking - Pennington NJ, US
Ruth E. Wager - Rockville MD, US
Thangavel Arunachalam - Plainsboro NJ, US
Karen E. Linder - Kingston NJ, US
Ramachandran S. Ranganathan - Princeton NJ, US
Adrian D. Nunn - Lambertville NJ, US
Nataranjan Raju - Kendall Park NJ, US
Michael F. Tweedle - Princeton NJ, US

Assignee:

Bracco International B.V. - Amsterdam

International Classification:

A61K 51/00
A61M 36/14

US Classification:

424 165, 424 111, 424 173, 424 91, 534 15

Abstract:

Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the α, γ, or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.

US Patent:

60933828, Jul 25, 2000

Filed:

May 16, 1998

Appl. No.:

9/080157

Inventors:

Paul W. Wedeking - Pennington NJ
Ruth E. Wager - Rockville MD
Thangavel Arunachalam - Plainsboro NJ
Karen E. Linder - Kingston NJ
Ramachandran S. Ranganathan - Princeton NJ
Adrian D. Nunn - Lambertville NJ
Natarajan Raju - Kendall Park NJ
Michael F. Tweedle - Princeton NJ

Assignee:

Bracco Research USA Inc. - Princeton NJ

International Classification:

A61K 5100
A61M 3614

US Classification:

424 165

Abstract:

Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the. alpha. ,. gamma. , or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.

US Patent:

62213342, Apr 24, 2001

Filed:

Jan 3, 2000

Appl. No.:

9/477072

Inventors:

Paul W. Wedeking - Pennington NJ
Ruth E. Wager - Rockville MD
Thangavel Arunachalam - Plainsboro NJ
Karen E. Linder - Kingston NJ
Ramachandran S. Ranganathan - Princeton NJ
Adrian D. Nunn - Lambertville NJ
Natarajan Raju - Kendall Park NJ
Michael F. Tweedle - Princeton NJ

Assignee:

Bracco Research USA, Inc. - Princeton NJ

International Classification:

A61K 5100

US Classification:

424 165

Abstract:

Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the. alpha. ,. gamma. , or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.

US Patent:

43495290, Sep 14, 1982

Filed:

Apr 14, 1980

Appl. No.:

6/140341

Inventors:

Nabil A. Morcos - South Brunswick NJ
Thomas A. Haney - East Brunswick NJ
Paul W. Wedeking - Cranbury NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

A61K 4300
A61K 4900
G01T 100

US Classification:

424 1

Abstract:

An article of manufacture comprising a pharmaceutical radioactive capsule formed essentially of a non-toxic, water soluble material adapted to being ingested and rapidly disintegrating on contact with fluids of the gastro-intestinal tract, and having a filler material supporting a pharmaceutically useful radioactive compound absorbable from the gastro-intestinal tract said filler material being supported by said capsule. And a method of filling a pharmaceutical radioactive capsule comprising providing filler material supporting a pharmaceutically useful radioactive compound and transporting said filler material carrying a pharmaceutically useful radioactive compound into the chamber of said capsule.

US Patent:

58690247, Feb 9, 1999

Filed:

Jun 5, 1992

Appl. No.:

7/893865

Inventors:

Ramachandran S. Ranganathan - Princeton NJ
Michael F. Tweedle - Princeton NJ
Paul W. Wedeking - Hillsborough NJ

Assignee:

Bracco International B.V. - Amsterdam

International Classification:

A61K 4904
A61K 3140
A61K 31535
A61K 3134

US Classification:

424944

Abstract:

In accordance with the present invention a novel method and composition for using nonionic contrast media to reduce the risk of clot formation in a diagnostic procedure is disclosed. Novel compositions for such method are also disclosed. The present method comprises employing a triiodinated phenyl contrast agent having a heterocyclic group or a dimeric triiodinated phenyl contrast agent having one or more heterocyclic groups.