Oren G Gilad

US Patent:

20170291911, Oct 12, 2017

Filed:

Apr 12, 2017

Appl. No.:

15/486017

Inventors:

- Lansdale PA, US
Oren Gilad - Ambler PA, US
Gerhard Sperl - Salem NH, US
Eric J. Brown - Wynnewood PA, US
Laura Butler - Blue Bell PA, US

International Classification:

C07D 515/04
A61K 31/4985
A61K 45/06

Abstract:

The disclosure is directed to compounds and compositions that inhibit Ataxia Telengiectasia And Rad3-Related (ATR) Protein Kinase and methods of their use.

US Patent:

20170226130, Aug 10, 2017

Filed:

Apr 27, 2017

Appl. No.:

15/498631

Inventors:

- Ambler PA, US
Oren Gilad - Ambler PA, US

International Classification:

C07D 519/00
C07D 515/18
C07D 498/18
C07D 515/08
C07D 498/08

Abstract:

Macrocyclic compounds having the structure of Formula (A), or pharmaceutically acceptable salts thereof, are provided,wherein R, R, R, Rand Rare defined herein. Also provided are pharmaceutical compositions comprising the macrocyclic compound and methods for treating cancer in a patient comprising administering to the patient the macrocyclic compound.

US Patent:

20160102104, Apr 14, 2016

Filed:

Oct 13, 2015

Appl. No.:

14/881680

Inventors:

- Ambler PA, US
Oren Gilad - Ambler PA, US

Assignee:

Atrin Pharmaceuticals LLC - Ambler PA

International Classification:

C07D 498/08
A61K 31/4985
A61N 5/10
C07D 498/18
A61K 31/5377
C07D 515/08
A61K 45/06

Abstract:

A macrocyclic compound having the structure of Formula (A), wherein each of Rand Ris independently (i) a 5-6 membered monocyclic aromatic ring containing 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or (ii) an 8-10 membered bicyclic aromatic ring containing 0-6 heteroatoms independently selected from nitrogen, oxygen, or sulfur. Each Rand Rmay independently be substituted by 0, 1, 2, 3, or 4 substituents. Zrepresents a covalent bond, an atom, or a functional group comprising a grouping of atoms, wherein the grouping of atoms includes at least one heteroatom selected from the group consisting of N, O, P, and S. Also, Zmay represent (i) a 5-6 membered monocyclic aromatic ring containing 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or (ii) an 8-10 membered bicyclic aromatic ring containing 0-6 heteroatoms independently selected from nitrogen, oxygen, or sulfur. Zrepresents a covalent bond, an atom, or a functional group comprising a grouping of atoms, wherein the grouping of atoms includes at least one heteroatom selected from the group consisting of N, O, P, and S. Variable v is an integer having a value of 1 or 0. T is a carbon atom, a nitrogen atom, a sulfur atom, or an oxygen atom. L is a linking group covalently bonded to T when v has a value of 1 or L is covalently bonded to Rwhen v has a value of 0. L is covalently bonded to Zwhen Zis an atom or a functional group comprising grouping of atoms and/or L is covalently bonded to Rwhen Zis a covalent bond. Each of R, Rand Rmay be the same as or different from each other and each is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl, and heteraralkyl, wherein each alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl, and heteraralkyl is optionally substituted by one or more suitable substituents.