Assaf A Gilad

US Patent:

20080284427, Nov 20, 2008

Filed:

Feb 7, 2006

Appl. No.:

11/883533

Inventors:

Peter C.M. van Zijl - Ellicott City MD, US
Assaf A. Gilad - Bethesda MD, US
Jeff Bulte - Fulton MD, US
Michael T. McMahon - Baltimore MD, US
Raman Venu - Ellicott City MD, US

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

G01R 33/48
C12Q 1/68
C07H 21/04

US Classification:

324307, 435 6, 536 231

Abstract:

Featured are a new class of reporter genes including reporter compositions as well as methods, MRI systems and MRI imaging kits related thereto. The genes according to the present invention provide MR contrast when the sample/subject is irradiated at a specific off-resonance radio-frequency (RF frequency), where the contrast mechanism utilizes chemical exchange saturation transfer (CEST) technique for imaging.

US Patent:

20120271159, Oct 25, 2012

Filed:

Apr 20, 2012

Appl. No.:

13/452221

Inventors:

Xiaolei Song - Lutherville-Timonium MD, US
Jeff W.M. Bulte - Fulton MD, US
Assaf A. Gilad - Baltimore MD, US
Michael T. McMahon - Columbia MD, US

Assignee:

THE JOHNS HOPKINS UNIVERSITY - Baltimore MD

International Classification:

A61B 5/055

US Classification:

600420

Abstract:

An embodiment in accordance with the present invention provides a method for obtaining a magnetic resonance image (MRI) or spectrum. The method includes a step of performing a chemical exchange saturation transfer (CEST) or magnetization transfer (MT) magnetic labeling experiment of a subject using an MRI machine. When performing the CEST or MT magnetic labeling experiment aspects of a saturation pulse or a serial saturation pulse sequence, such as length (t), number (N), offset (Δω), modulation frequency (ω) and power (B) can be varied in specific-designed schemes. Data is generated from the CEST magnetic labeling experiment and is transmitted to a data processing unit. The data is processed to generate a visual representation of the data.

US Patent:

20130058874, Mar 7, 2013

Filed:

Aug 3, 2012

Appl. No.:

13/566785

Inventors:

Peter C.M. van Zijl - Ellicott City MD, US
Assaf A. Gilad - Bethesda MD, US
Jeff Bulte - Fulton MD, US
Michael T. McMahon - Baltimore MD, US
Raman Venu - Ellicott City MD, US

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

A61K 49/14
C12N 15/11
G01R 33/32
C12N 15/63

US Classification:

424 934, 4353201, 536 231, 324318

Abstract:

Featured are a new class of reporter genes including reporter compositions as well as methods, MRI systems and MRI imaging kits related thereto. The genes according to the present invention provide MR contrast when the sample/subject is irradiated at a specific off-resonance radio-frequency (RF frequency), where the contrast mechanism utilizes chemical exchange saturation transfer (CEST) technique for imaging.