John Fraser Wright - Princeton NJ, US Olga Zelenaia - Ardmore PA, US Bernd Hauck - Hamilton NJ, US Federico Mingozzi - Paris, FR Katherine A. High - Merion Station PA, US
Assignee:
THE CHILDREN'S HOSPITAL OF PHILADELPHIA - Philadelphia PA
International Classification:
C12N 15/86 A61K 38/48 A61K 48/00
US Classification:
424 932, 4353201
Abstract:
Improved compositions and methods for AAV mediated gene therapy are disclosed.
Vectors Comprising Stuffer/Filler Polynucleotide Sequences And Methods Of Use
- Philadelphia PA, US Olga ZELENAIA - Philadelphia PA, US
Assignee:
THE CHILDREN'S HOSPITAL OF PHILADELPHIA - Philadelphia PA
International Classification:
C12N 15/86 A61K 48/00 C12N 7/00
Abstract:
Recombinant viral vectors such as AAV vectors designed with expression cassettes that approach the natural packaging capacity of the virus, such as AAV are provided. The recombinant viral vectors reduce residual plasmid DNA impurities.