Mark Jay Rosenfeld

US Patent:

6933123, Aug 23, 2005

Filed:

Jul 1, 2003

Appl. No.:

10/612818

Inventors:

Yao Xiong Hu - Mountain View CA, US
Mark J. Rosenfeld - Draper UT, US

International Classification:

G01N033/53

US Classification:

435 71, 435 791, 435 6, 435 5, 435 794

Abstract:

An isolated protein sequence or peptide from the E2, E6 or E7 early coding region of human papillomavirus (HPV) that is soluble in an aqueous medium, and characterized by a relative paucity of tryptophan, methionine and cysteine residues, and a relative abundance of glycine and asparagine residues. Also disclosed are isolated protein sequences or peptides from the E2, E6 or E7 early coding regions of HPV 16 and 18 and methodologies for detecting or diagnosing cancer or cellular abnormalities. Detection or diagnosis of Cancer or cellular abnormalities may include detecting or diagnosing pre-cancerous or pre-malignant conditions, cervical dysplasia, cervical carcinoma, koilocytosis, hyperkeratosis, intraepithelial lesions, and other cancers. A methodology for detecting or diagnosing cancer or cellular abnormalities comprises the steps of (1) reacting a sample of body fluid or tissue with isolated protein sequences or peptides; (2) forming an antibody-peptide complex; and (3) detecting the antibody-peptide complex.

US Patent:

7316908, Jan 8, 2008

Filed:

Aug 22, 2005

Appl. No.:

11/209206

Inventors:

Yao Xiong Hu - Mountain View CA, US
Mark J. Rosenfeld - Draper UT, US

International Classification:

G01N 33/53

US Classification:

435 71, 435 6, 435 791

Abstract:

An isolated protein sequence or peptide from the E2, E6 or E7 early coding region of human papillomavirus (HPV) that is soluble in an aqueous medium, and characterized by a relative paucity of tryptophan, methionine and cysteine residues, and a relative abundance of glycine and asparagine residues. Also disclosed are isolated protein sequences or peptides from the E2, E6 or E7 early coding regions of HPV 16 and 18 and methodologies for detecting or diagnosing cancer or cellular abnormalities. Detection or diagnosis of Cancer or cellular abnormalities may include detecting or diagnosing pre-cancerous or pre-malignant conditions, cervical dysplasia, cervical carcinoma, koilocytosis, hyperkeratosis, intraepithelial lesions, and other cancers. A methodology for detecting or diagnosing cancer or cellular abnormalities comprises the steps of (1) reacting a sample of body fluid or tissue with isolated protein sequences or peptides; (2) forming an antibody-peptide complex; and (3) detecting the antibody-peptide complex.

US Patent:

7507731, Mar 24, 2009

Filed:

Mar 30, 2006

Appl. No.:

11/393312

Inventors:

Mark J. Rosenfeld - Draper UT, US
Scott R. Forsberg - Layton UT, US

Assignee:

Seroctin Research & Technology, Inc. - Salt Lake City UT

International Classification:

A61K 31/535
A61K 36/899

US Classification:

5142305, 5142308, 514909, 424750

Abstract:

Phenolic compounds with a phenolic molecule to which are covalently linked an oxygen-containing group, a nitrogen or another oxygen containing group, and a C-Calkoxy group, obtainable from monocotyledonous plants, or by chemical synthesis, have been found to act as weight loss agents, appetite suppressants, mood enhancers and adjunctive therapy for arthritis, sleep apnea, fibromyalgia, diabetes and hyperglycemia. Additional chemical compounds of the present invention may include benzoxazinoids-cyclic hydroxyamic acids, lactams, and corresponding glucosides, which may serve as precursors to phenolic compounds. The phenolic compounds and precursors of phenolic compounds of the present invention, at concentrations suitable for human therapeutic use, may be obtained from monocotyledonous plants such as corn in their early growth states which are timely harvested for optimum yield.

US Patent:

7521467, Apr 21, 2009

Filed:

Mar 16, 2006

Appl. No.:

11/377582

Inventors:

Mark J. Rosenfeld - Draper UT, US
Scott R. Forsberg - Layton UT, US

Assignee:

Seroctin Research & Technology, Inc. - Salt Lake City UT

International Classification:

A61K 31/42
A61K 36/899

US Classification:

514375, 424450

Abstract:

Phenolic compounds with a phenolic molecule to which are covalently linked an oxygen-containing group, a nitrogen or another oxygen containing group, and a C-Calkoxy group, obtainable from monocotyledonous plants, or by chemicals synthesis, have been found to act as weight loss agents, appetite suppressants, mood enhancers and adjunctive therapy for arthritis, sleep apnea, fibromyalgia, diabetes and hyperglycemia. Additional chemical compounds of the present invention may include benzoxazinoids-cyclic hydroxyamic acids, lactams, and corresponding glucosides, which may serve as precursors to phenolic compounds. The phenolic compounds and precursors of phenolic compounds of the present invention, at concentrations suitable for human therapeutic use, may be obtained from monocotyledonous plants such as corn in their early growth states which are timely harvested for optimum yield.

US Patent:

7521468, Apr 21, 2009

Filed:

Mar 21, 2006

Appl. No.:

11/385415

Inventors:

Mark J. Rosenfeld - Draper UT, US
Scott R. Forsberg - Mountain Green UT, US

Assignee:

Seroctin Research & Technology, Inc. - Salt Lake City UT

International Classification:

A61K 31/42
A61K 36/899

US Classification:

514376, 514374, 514375, 514909, 424750

Abstract:

Phenolic compounds with a phenolic molecule to which are covalently linked an oxygen-containing group, a nitrogen or another oxygen containing group, and a C-Calkoxy group, obtainable from monocotyledonous plants, or by chemical synthesis, have been found to act as weight loss agents, appetite suppressants, mood enhancers and adjunctive therapy for arthritis, sleep apnea, fibromyalgia, diabetes and hyperglycemia. Additional chemical compounds of the present invention may include benzoxazinoids-cyclic hydroxyamic acids, lactams, and corresponding glucosides, which may serve as precursors to phenolic compounds. The phenolic compounds and precursors of phenolic compounds of the present invention, at concentrations suitable for human therapeutic use, may be obtained from monocotyledonous plants such as corn in their early growth states which are timely harvested for optimum yield.

US Patent:

7524877, Apr 28, 2009

Filed:

Mar 9, 2006

Appl. No.:

11/371689

Inventors:

Mark J. Rosenfeld - Draper UT, US
Scott R. Forsberg - Layton UT, US

Assignee:

Seroctin Research & Technology, Inc. - Salt Lake City UT

International Classification:

A61K 31/42
A61K 36/899

US Classification:

514376, 514374, 514375, 514909, 424750

Abstract:

Phenolic compounds with a phenolic molecule to which are covalently linked an oxygen-containing group, a nitrogen or another oxygen containing group, and a C-Calkoxy group, obtainable from monocotyledonous plants, or by chemical synthesis, have been found to act as weight loss agents, appetite suppressants mood enhancers and adjunctive therapy for arthritis, sleep apnea, fibromyalgia, diabetes and hyperglycemia. Additional chemical compounds of the present invention may include benzoxazinoids-cyclic hydroxyamic acids, lactams, and corresponding gluxosides, which may serve as precursors to phenolic compounds. The phenolic compounds and precursors of phenolic compounds of the present invention, at concentrations suitable for human therapeutic use, may be obtained from monocotyledonous plants such as corn in their early growth states which are timely harvested for optimum yield.

US Patent:

7541356, Jun 2, 2009

Filed:

Mar 28, 2006

Appl. No.:

11/390738

Inventors:

Mark J. Rosenfeld - Draper UT, US
Scott R. Forsberg - Layton UT, US

Assignee:

Seroctin Research & Technology, Inc. - Salt Lake City UT

International Classification:

A61K 31/535
A61K 36/899

US Classification:

5142305, 5142308, 514909, 424750

Abstract:

Phenolic compounds with a phenolic molecule to which are covalently linked an oxygen-containing group, a nitrogen or another oxygen containing group, and a C-Calkoxy group, obtainable from monocotyledonous plants, or by chemical synthesis, have been found to act as weight loss agents, appetite suppressants, mood enhancers and adjunctive therapy for arthritis, sleep apnea, fibromyalgia, diabetes and hyperglycemia. Additional chemical compounds of the present invention may include benzoxazinoids-cyclic hydroxyamic acids, lactams, and corresponding glucosides, which may serve as precursors to phenolic compounds. The phenolic compounds and precursors of phenolic compounds of the present invention, at concentrations suitable for human therapeutic use, may be obtained from monocotyledonous plants such as corn in their early growth states which are timely harvested for optimum yield.

US Patent:

7794761, Sep 14, 2010

Filed:

Jul 11, 2005

Appl. No.:

11/178998

Inventors:

Nancy J. Shelby - Bozeman MT, US
Mitchell T. Godfrey - Bozeman MT, US
Mark J. Rosenfeld - Draper UT, US

Assignee:

Seroctin Research & Technology, Inc. - Salt Lake City UT

International Classification:

A61K 36/89
A61K 31/428
A61K 31/538

US Classification:

424750, 5142305, 514375, 514376

Abstract:

Phenolic compounds with a phenolic molecule to which are covalently linked an oxygen-containing group, a nitrogen or another oxygen containing group, and a C-Calkoxy group, or their precursor compounds, obtainable from monocotyledonous plants, or by chemical synthesis, have been found to calm and/or reduce anxiety and related behaviors and states in humans and animals. Additional chemical compounds of the present invention may include benzoxazinoids-cyclic hydroxyamic acids, lactams, and corresponding glucosides, which may serve as precursors to phenolic compounds. The phenolic compounds and precursors of phenolic compounds of the present invention, at concentrations suitable for human and animal therapeutic use, may be obtained from monocotyledonous plants such as corn in their early growth states which are timely harvested for optimum yield.