Maha Yehia Khaled

US Patent:

20030171437, Sep 11, 2003

Filed:

Mar 6, 2003

Appl. No.:

10/383041

Inventors:

Jurij Holinej - Hackettstown NJ, US
Yatindra Joshi - Princeton NJ, US
Anees Karnachi - Hillsborough NJ, US
Maha Khaled - Livingston NJ, US

International Classification:

A61K031/195

US Classification:

514/567000

Abstract:

A method of treating a cyclooxygenase-2 dependent disorder or condition comprising administering a solid formulation of 5-methyl-2-(2′-chloro-6′-fluoroanilino)phenylacetic acid which has a residual moisture within predetermined levels.

US Patent:

20040186179, Sep 23, 2004

Filed:

Mar 24, 2004

Appl. No.:

10/807734

Inventors:

Alberto Gimona - Basel, CH
Richard Macerata - Summit NJ, US
Jasper Huels - Huningue, FR
Eimear Nic Lochlainn - Dublin, IE
Argeris Karabelas - Princeton NJ, US
Simon Bateman - Randolph NJ, US
Jurij Holinej - Hackettstown NJ, US
Anees Karnachi - Hillsborough NJ, US
Maha Khaled - Livingston NJ, US
Victor Sloan - Scotch Plains NJ, US
Sumedha Jayawardene - Bridgewater NJ, US

International Classification:

A61K031/195

US Classification:

514/567000

Abstract:

A method of treating a cyclooxygenase-2 dependent disorder or condition comprising administering 5-methyl-2-(2′-chloro-6′-fluoroanilino)phenylacetic acid or a pharmaceutically acceptable salt thereof in an amount effective to treat such a disorder or condition for about 24 hours, comprising administering orally once a day to a human in need of such treatment one or more immediate release pharmaceutical compositions comprising 5-methyl-2-(2′-chloro-6′-fluoroanilino)phenylacetic acid or a pharmaceutically acceptable salt thereof, and compositions suitable for use in such methods.

US Patent:

20050123604, Jun 9, 2005

Filed:

Mar 6, 2003

Appl. No.:

10/506821

Inventors:

Anees Karnachi - Hillsborough NJ, US
Maha Khaled - Livingston NJ, US
Jurij Holinej - Hackettstown NJ, US
Yatindra Joshi - Princeton NJ, US

International Classification:

A61K031/195
A61K009/20

US Classification:

424464000, 514567000

Abstract:

A method of treating a cyclooxygenase-2 dependent disorder or condition comprising administering 5-methyl-2-(2′-chloro-6′-fluoroanilino)phenylacetic acid in an amount effective to treat such a disorder or condition for about 24 hours, comprising administering orally once a day to a human in need of such treatment one or more immediate release pharmaceutical compositions comprising 5-methyl-2-(2′-chloro-6′-fluoroanilino)phenylacetic acid, and compositions suitable for use in such methods.

US Patent:

20060094787, May 4, 2006

Filed:

Mar 11, 2004

Appl. No.:

10/549249

Inventors:

Patrick Forenzo - Glen Gardner NJ, US
Maha Khaled - Livingston NJ, US
Barbara Wang - Berkeley Heights NJ, US
Joseph Zielinski - Florham Park NJ, US

International Classification:

A61K 31/195
A61K 9/00

US Classification:

514567000, 424400000

Abstract:

Provided are compositions comprising aqueous suspensions of 5-methyl-2-(2′-chloro-6′-fluoroanilino)phenylacetic acid suitable for oral administration. Methods for making such compositions and methods for their stabilization are provided.

US Patent:

20070087051, Apr 19, 2007

Filed:

Dec 14, 2006

Appl. No.:

11/639172

Inventors:

Jurij Holinej - Hackettstown NJ, US
Yatindra Joshi - Princeton NJ, US
Anees Karnachi - Hillsborough NJ, US
Maha Khaled - Livingston NJ, US

International Classification:

A61K 9/20
A61K 31/195

US Classification:

424464000, 514567000

Abstract:

A method of treating a cyclooxygenase-2 dependent disorder or condition comprising administering a solid formulation of 5-methyl-2-(2′-chloro-6′-fluoroanilino)phenylacetic acid which has a residual moisture within predetermined levels.

US Patent:

20080287543, Nov 20, 2008

Filed:

Jul 21, 2008

Appl. No.:

12/220060

Inventors:

Rose-Marie Dannenfelser - Bloomfield NJ, US
Vivia Christine Georgousis - West caldwell NJ, US
Maha Y. Khaled - Livingston NJ, US
Tarun S. Patel - Parsippany NJ, US
Joseph Sikora - Saccasunna NJ, US
Barbara Wang - Berkeley Heights NJ, US

International Classification:

A61K 31/195
A61P 29/00

US Classification:

514567

Abstract:

The invention relates to a composition for the treatment of a cyclooxygenase-2-mediated disorder or condition comprising 5-methyl-2-(2′-chloro-6′-fluoroanilino)phenylacetic acid or a pharmaceutically acceptable salt, preferably the potassium salt, thereof suitable for parenteral administration, and to a method for the treatment of a cyclooxygenase-2-mediated disorder or condition in a human or animal in need of such treatment by parenteral administration of 5-methyl-2-(2′-chloro-6′-fluroanilino)phenylacetic acid or a pharmaceutically acceptable salt, preferably the potassium salt, thereof.

US Patent:

20090048344, Feb 19, 2009

Filed:

Oct 7, 2008

Appl. No.:

12/287231

Inventors:

Patrick Forenzo - Glen Gardner NJ, US
Maha Y. Khaled - Livingston NJ, US
Barbara Wang - Berkeley Heights NJ, US
Joseph Lawrence Zielinski - Florham Park NJ, US

International Classification:

A61K 31/196

US Classification:

514567

Abstract:

Provided are compositions comprising aqueous suspensions of 5-methyl-2-(2′-chloro-6′-fluoroanilino)phenylacetic acid suitable for oral administration. Methods for making such compositions and methods for their stabilization are provided.

US Patent:

20090149543, Jun 11, 2009

Filed:

Feb 6, 2009

Appl. No.:

12/366989

Inventors:

Anees Abdulquadar Karnachi - Hillsborough NJ, US
Maha Y. Khaled - Livingston NJ, US
Jurij Holinej - Hackettstown NJ, US
Yatindra Joshi - Princeton NJ, US

International Classification:

A61K 31/195
C07C 229/40
A61P 29/00

US Classification:

514567, 562456

Abstract:

A method of treating a cyclooxygenase-2 dependent disorder or condition comprising administering 5-methyl-2-(2′-chloro-6′-fluoroanilino)phenylacetic acid in an amount effective to treat such a disorder or condition for about 24 hours, comprising administering orally once a day to a human in need of such treatment one or more immediate release pharmaceutical compositions comprising 5-methyl-2-(2′-chloro-6′-fluoroanilino)phenylacetic acid, and compositions suitable for use in such methods.