Lijun Jun Dai

US Patent:

20090098057, Apr 16, 2009

Filed:

Oct 16, 2007

Appl. No.:

11/872866

Inventors:

Shiying Zheng - Center Valley PA, US
Lijun Dai - Rochester NY, US
Ruizheng Wang - Rochester NY, US
Tiecheng A. Qiao - Webster NY, US
Wenyi Che - Rochester NY, US
William J. Harrison - Pittsford NY, US

International Classification:

A61K 49/00
A61B 5/00

US Classification:

424 96

Abstract:

A nanoparticulate imaging probe with an oxide core, a biocompatible polymeric shell covalently attached to the oxide core, a dye, and a cleavable spacer that covalently binds the dye to the probe. When the spacer is cleaved, the dye is liberated from the probe. The emissions of the dye are quenched when the dye is bound to the probe and not quenched when the dye is liberated from the probe. The spacer can be, for example, a peptide. The oxide core can be, for example, a silicon oxide core.

US Patent:

20090169482, Jul 2, 2009

Filed:

Oct 31, 2007

Appl. No.:

11/930417

Inventors:

Shiying Zheng - Center Valley PA, US
Lijun Dai - Rochester NY, US
Ruizheng Wang - Rochester NY, US
Tiecheng A. Qiao - Webster NY, US
Wenyi Che - Rochester NY, US
William J. Harrison - Pittsford NY, US

International Classification:

A61K 49/00

US Classification:

424 96

Abstract:

A nanoparticulate imaging probe with an oxide core, a biocompatible polymeric shell covalently attached to the oxide core, a dye, and a cleavable spacer that covalently binds the dye to the probe. When the spacer is cleaved, the dye is liberated from the probe. The emissions of the dye are quenched when the dye is bound to the probe and not quenched when the dye is liberated from the probe. The spacer can be, for example, a peptide. The oxide core can be, for example, a silicon oxide core.

US Patent:

20110130305, Jun 2, 2011

Filed:

Nov 30, 2009

Appl. No.:

12/592639

Inventors:

Wayne Forrest Patton - Dix Hills NY, US
Sergiy M. Yarmoluk - Kyiv, UA
Praveen Pande - Holbrook NY, US
Vladyslava Kovalska - Kyiv, UA
Lijun Dai - Farmingville NY, US
Kateryna Volkova - Kyiv, UA
Jack Coleman - East Northport NY, US
Mykhaylo Losytskyy - Kyiv, UA
Anthony Ludlum - Ypsilanti MI, US
Anatoliy Balanda - Kyiv, UA

International Classification:

C40B 40/04
C07D 213/02
C07D 213/04
C07D 277/20
C07D 277/62
C07D 285/06
C07D 471/04
C07D 215/12
C07D 277/60
C07D 251/00
C07K 2/00
C07K 14/00
C07H 21/00
C12N 9/00
C07K 16/00
C12N 1/20
G01N 33/53
G01N 33/554
G01N 33/567
C07K 1/00

US Classification:

506 15, 546264, 546255, 548202, 548152, 548127, 544247, 546176, 548149, 544180, 530300, 530350, 536 231, 435183, 5303873, 4352521, 435 72, 435 721, 435 732, 435 71, 530412

Abstract:

Provided are dyes and compositions which are useful in a number of applications, such as the detection and monitoring protein aggregation, kinetic studies of protein aggregation, neurofibrillary plaques analysis, evaluation of protein formulation stability, protein thermal stability shift assay and analysis of molecular chaperone activity. These dyes and compositions are also useful as probes in nucleic acid and protein detection.

US Patent:

20130137112, May 30, 2013

Filed:

Nov 30, 2010

Appl. No.:

13/510976

Inventors:

Wayne Forrest Patton - Dix Hills NY, US
Sergiy M. Yarmoluk - Kyiv, UA
Praveen Pande - Holbrook NY, US
Vladyslava Kovalska - Kyiv, UA
Lijun Dai - Fredonia NY, US
Kateryna Volkova - Kyiv, UA
Jack Coleman - East Northport NY, US
Mykhaylo Losytskyy - Kyiv, UA
Anthony Ludlam - Ypsilanti MI, US
Anatoliy Balanda - Kyiv, UA
Dee Shen - Winchester MA, US

International Classification:

C07D 401/12

US Classification:

435 71, 436501, 546264, 530413, 546177

Abstract:

Provided are dyes and compositions which are useful in a number of applications, such as the detection and monitoring protein aggregation, kinetic studies of protein aggregation, neurofibrillary plaques analysis, evaluation of protein formulation stability, and analysis of molecular chaperone activity.

US Patent:

20070237821, Oct 11, 2007

Filed:

Apr 10, 2006

Appl. No.:

11/401343

Inventors:

Jeffrey Leon - Rochester NY, US
James Bennett - Rochester NY, US
Tiecheng Qiao - Webster NY, US
John Harder - Rochester NY, US
Thomas Mourey - Rochester NY, US
Gary Slater - Rochester NY, US
Lijun Dai - Rochester NY, US

International Classification:

A61K 9/14

US Classification:

424484000

Abstract:

The present invention relates to a nanogel comprising a polymer network of repetitive, crosslinked, ethylenically unsaturated monomers of Formula I: (X)m-(Y)n-(Z)o  Formula I wherein X is a water-soluble monomer containing ionic or hydrogen bonding moieties; Y is a water-soluble macromonomer containing repetitive hydrophilic units bound to a polymerizeable ethylenically unsaturated group; Z is a multifunctional crosslinking monomer; m ranges from 50-90 mol %; n ranges from 2-30 mol %; and o range from 1-15 mol % and a method for preparing a nanogel comprising preparing a header composition of a mixture of monomers X, Y, and Z, and a first portion of initiators in water; preparing a reactor composition of a second portion initiators, surfactant, and water; bringing the reactor composition to the polymerization temperature; holding the reactor composition at the polymerization temperature, and adding the header composition to the reactor composition to form a nanogel of Formula I.

US Patent:

20210009809, Jan 14, 2021

Filed:

Aug 6, 2020

Appl. No.:

16/986311

Inventors:

- Farmingdale NY, US
Sergiy M. Yarmoluk - Kyiv, UA
Praveen Pande - Holbrook NY, US
Vladyslava Kovalska - Kyiv, UA
Lijun Dai - Farmingville NY, US
Kateryna Volkova - Kyiv, UA
Jack Coleman - East Northport NY, US
Mykhaylo Losytskyy - Kyiv, UA
Anthony Ludlam - Ypsilanti MI, US
Anatoliy Balanda - Kyiv, UA
Dee Shen - Glen Head NY, US

Assignee:

Enzo Life Sciences, Inc. - Farmingdale NY

International Classification:

C09B 23/14
C09B 23/01
C09B 23/04
C09B 23/06
C09B 23/10
G01N 33/58
G01N 33/68
C07D 401/12

Abstract:

Provided are dyes and compositions which are useful in a number of applications, such as the detection and monitoring protein aggregation, kinetic studies of protein aggregation, neurofibrillary plaques analysis, evaluation of protein formulation stability, and analysis of molecular chaperone activity.

US Patent:

20180273759, Sep 27, 2018

Filed:

Apr 26, 2018

Appl. No.:

15/963441

Inventors:

- Farmingdale NY, US
Sergiy M. Yarmoluk - Kyiv, UA
Praveen Pande - Holbrook NY, US
Vladyslava Kovalska - Kyiv, UA
Lijun Dai - Farmingville NY, US
Kateryna Volkova - Kyiv, UA
Jack Coleman - East Northport NY, US
Mykhaylo Losytskyy - Kyiv, UA
Anthony Ludlam - Ypsilanti MI, US
Anatoliy Balanda - Kyiv, UA
Dee Shen - Glen Head NY, US

Assignee:

Enzo Life Sciences, Inc. - Farmingdale NY

International Classification:

C09B 23/14
G01N 33/68
G01N 33/58

Abstract:

Provided are dyes and compositions which are useful in a number of applications, such as the detection and monitoring protein aggregation, kinetic studies of protein aggregation, neurofibrillary plaques analysis, evaluation of protein formulation stability, and analysis of molecular chaperone activity.

US Patent:

20160280921, Sep 29, 2016

Filed:

May 17, 2016

Appl. No.:

15/156565

Inventors:

- Farmingdale NY, US
Sergiy M. Yarmoluk - Kyiv, UA
Praveen Pande - Holbrook NY, US
Vladyslava Kovalska - Kyiv, UA
Lijun Dai - Farmingville NY, US
Kateryna Volkova - Kyiv, UA
Jack Coleman - East Northport NY, US
Mykhaylo Losytskyy - Kyiv, UA
Anthony Ludlum - Ypsilanti MI, US
Anatoliy Balanda - Kyiv, UA
Dee Shen - Glen Head NY, US

Assignee:

Enzo Life Sciences, Inc. - Farmingdale NY

International Classification:

C09B 23/14
G01N 33/68
G01N 33/58

Abstract:

Provided are dyes and compositions which are useful in a number of applications, such as the detection and monitoring protein aggregation, kinetic studies of protein aggregation, neurofibrillary plaques analysis, evaluation of protein formulation stability, and analysis of molecular chaperone activity.