Kristine M Swiderek

US Patent:

7556941, Jul 7, 2009

Filed:

Oct 17, 2006

Appl. No.:

11/550155

Inventors:

Brian A. Fox - Seattle WA, US
Margaret Dow Moore - Seattle WA, US
Kristine M. Swiderek - Woodinville WA, US
Carl W. Birks - Seattle WA, US

Assignee:

ZymoGenetics, Inc. - Seattle WA

International Classification:

C12P 21/04
C12N 15/00
C12N 5/00
C07H 21/04

US Classification:

435 697, 536 234, 536 235, 4353201, 435325, 435 698

Abstract:

Proteins consisting of, from amino to carboxyl terminus, a first PDGF-D growth factor domain polypeptide, a linker polypeptide, and a second PDGF-D growth factor domain polypeptide, and materials and methods for making the proteins are disclosed. Each of the first and second PDGF-D growth factor domain polypeptides consists of a sequence of amino acid residues as shown in SEQ ID NO: 2 or SEQ ID NO: 4 from amino acid x to amino acid y, wherein x is an integer from 246 to 258, inclusive, and y is an integer from 365-370, inclusive. The linker polypeptide consists of from 11-40 amino acid residues. The proteins can be used to stimulate the production of bone and/or connective tissue in both humans and non-human animals.

US Patent:

20030224488, Dec 4, 2003

Filed:

Feb 11, 2003

Appl. No.:

10/365095

Inventors:

Brian Fox - Seattle WA, US
Margaret Moore - Seattle WA, US
Kristine Swiderek - Woodinville WA, US
Carl Birks - Seattle WA, US

International Classification:

C12P021/04
C07H021/04
C12N005/06
C07K014/49

US Classification:

435/069700, 435/320100, 435/325000, 530/399000, 536/023500

Abstract:

Proteins consisting of, from amino to carboxyl terminus, a first PDGF-D growth factor domain polypeptide, a linker polypeptide, and a second PDGF-D growth factor domain polypeptide, and materials and methods for making the proteins are disclosed. Each of the first and second PDGF-D growth factor domain polypeptides consists of a sequence of amino acid residues as shown in SEQ ID NO: 2 or SEQ ID NO: 4 from amino acid x to amino acid y, wherein x is an integer from 246 to 258, inclusive, and y is an integer from 365-370, inclusive. The linker polypeptide consists of from 11-40 amino acid residues. The proteins can be used to stimulate the production of bone and/or connective tissue in both humans and non-human animals.

US Patent:

20220177587, Jun 9, 2022

Filed:

Sep 19, 2019

Appl. No.:

17/275646

Inventors:

- Seattle WA, US
Mark F. MAURER - Seattle WA, US
Stanford L. PENG - Seattle WA, US
Jing YANG - Seattle WA, US
Kristine M. SWIDEREK - Seattle WA, US

Assignee:

Alpine Immune Sciences, Inc. - Seattle WA

International Classification:

C07K 16/28
A61K 31/282
C07K 14/705
C12N 15/62
A61P 35/00
A61K 45/06

Abstract:

Provided herein are variant CD80 polypeptides, immunomodulatory proteins comprising variant CD80 polypeptides, and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of oncological conditions. Compositions and methods for making and using such proteins are provided.

US Patent:

20140328797, Nov 6, 2014

Filed:

Apr 28, 2014

Appl. No.:

14/263305

Inventors:

- Seattle WA, US
Kristine Swiderek - Seattle WA, US

International Classification:

A61K 39/42
A61K 39/125
A61K 45/06
C07K 16/10
C12N 7/00

US Classification:

424 855, 53038815, 5303894, 5303883, 536 2353, 4353201, 435339, 530358, 4241421, 424 854, 4242161, 424 857, 4352523, 43525233, 4352542, 43525421, 43525231, 43525234, 43525235, 43525422, 43525423, 4352546, 4352544, 4352545, 4352543

Abstract:

The invention provides isolated fully human monoclonal anti-HRV antibodies, as well as method of making and using these antibodies. Anti-HRV antibodies of the invention prevent or treat subjects having HRV-infections, and related diseases, including, but not limited to, the common cold, nasopharyngitis, croup, pneumonia, bronchiolitis, asthma, chronic obstructive pulmonary disease (COPD), sinusitis, bacterial superinfection, and cystic fibrosis.