Piotr M Swiderski

US Patent:

6379931, Apr 30, 2002

Filed:

Aug 9, 2000

Appl. No.:

09/634918

Inventors:

John J. Rossi - Alta Loma CA
Piotr M. Swiderski - San Dimas CA

Assignee:

City of Hope - Duarte CA

International Classification:

C12P 1934

US Classification:

435 9131, 435 6, 536 231, 536 2372, 536 245, 536 253

Abstract:

DNA-RNA-(Pr) -RNA-DNA ribozymes of formula III or IV: in which X and Z comprise DNA sequences that base pair with an RNA substrate at positions adjacent to an RNA cleavage site; cugaugag and cgaaa are catalytic RNA sequences; Pr is a spacer residue âP(O)(OH)âOâCH CH CH âOâ; and R is a bridging residue âOâCH âC(CH OH)(CH )âCH âOâ. The ribozymes can be made on any DNA synthesizer using phosphoramidite chemistry, and are useful as therapeutic agents for treating viral or endogenous RNA-mediated diseases. Preferred ribozymes target a sequence in the U5 region of HIV-1.

US Patent:

20030228596, Dec 11, 2003

Filed:

Mar 13, 2003

Appl. No.:

10/387324

Inventors:

Qiang Liu - Upland CA, US
Piotr Swiderski - San Dimas CA, US
Steve Sommer - Duarte CA, US

International Classification:

C12Q001/68
C12P019/34

US Classification:

435/006000, 435/091200

Abstract:

Truncated amplification (TA) provides high fidelity, template driven amplification of target nucleic acid molecules in which truncating oligonucleotides are used as primers to produce truncated terminal products that are in most, if not all, cases no more than three rounds of replication from the original template. In certain embodiments, TA can amplify target nucleic acids quadratically or geometrically, depending on the number of truncating oligonucleotides used for amplification.

US Patent:

20080214436, Sep 4, 2008

Filed:

Dec 28, 2007

Appl. No.:

11/966423

Inventors:

Hua YU - Glendora CA, US
Marcin KORTYLEWSKI - Monrovia CA, US
Richard JOVE - Glendora CA, US
Piotr Marek SWIDERSKI - San Dimas CA, US
John J. ROSSI - Alta Loma CA, US

Assignee:

CITY OF HOPE - Duarte CA

International Classification:

A61K 38/00
C07H 21/00
C07K 1/00
A61P 43/00
A61K 31/70

US Classification:

514 2, 536 245, 536 231, 530300, 514 44

Abstract:

The present invention relates to methods and compositions for the treatment of diseases, including cancer, infectious diseases and autoimmune diseases. The present invention also relates to methods and compositions for improving immune function. More particularly, the present invention relates to multifunctional molecules that are capable of being delivered to cells of interest for the treatment of diseases and for the improvement in immune function.

US Patent:

20110071210, Mar 24, 2011

Filed:

Sep 10, 2010

Appl. No.:

12/879199

Inventors:

Hua YU - Glendora CA, US
Marcin KORTYLEWSKI - Monrovia CA, US
Richard JOVE - Glendora CA, US
Piotr Marek SWIDERSKI - San Dimas CA, US
John J. ROSSI - Alta Loma CA, US

Assignee:

CITY OF HOPE - DUARTE CA

International Classification:

A61K 48/00
C07H 21/04
C07H 21/02
A61P 31/00
A61P 37/06
A61P 35/00

US Classification:

514 44 A, 536 241, 514 44 R

Abstract:

The present invention relates to methods and compositions for the treatment of diseases, including cancer, infectious diseases and autoimmune diseases. The present invention also relates to methods and compositions for improving immune function. More particularly, the present invention relates to multifunctional molecules that are capable of being delivered to cells of interest for the treatment of diseases and for the improvement in immune function.

US Patent:

20120065125, Mar 15, 2012

Filed:

Sep 9, 2011

Appl. No.:

13/229146

Inventors:

Hua YU - Glendora CA, US
Marcin KORTYLEWSKI - Monrovia CA, US
Richard JOVE - Glendora CA, US
Piotr Marek SWIDERSKI - San Dimas CA, US
John J. ROSSI - Alta Loma CA, US

Assignee:

CITY OF HOPE - Duarte CA

International Classification:

A61K 31/713
A61K 31/7105
A61P 37/00
A61P 31/00
A61P 7/00
A61K 38/02
C07H 21/02
A61P 35/00

US Classification:

514 23, 536 245, 514 44 A, 514 44 R, 514 193, 514 133, 536 235

Abstract:

The present invention relates to methods and compositions for the treatment of diseases, including cancer, infectious diseases and autoimmune diseases. The present invention also relates to methods and compositions for improving immune function. More particularly, the present invention relates to multifunctional molecules that are capable of being delivered to cells of interest for the treatment of diseases and for the improvement in immune function.

US Patent:

20140066592, Mar 6, 2014

Filed:

Oct 11, 2013

Appl. No.:

14/052621

Inventors:

Marcin KORTYLEWSKI - Monrovia CA, US
Richard JOVE - Glendora CA, US
Piotr Marek SWIDERSKI - San Dimas CA, US
John J. ROSSI - Alta Loma CA, US

Assignee:

City of Hope - Duarte CA

International Classification:

A61K 47/48

US Classification:

530322, 536 231, 536 245

Abstract:

The present invention relates to methods and compositions for the treatment of diseases, including cancer, infectious diseases and autoimmune diseases. The present invention also relates to methods and compositions for improving immune function. More particularly, the present invention relates to multifunctional molecules that are capable of being delivered to cells of interest for the treatment of diseases and for the improvement in immune function.

US Patent:

57665508, Jun 16, 1998

Filed:

Mar 14, 1996

Appl. No.:

8/616052

Inventors:

Bruce E. Kaplan - Claremont CA
Piotr M. Swiderski - San Dimas CA

Assignee:

City of Hope - Duarte CA

International Classification:

G01N 1506
C07N 2104
A61K 914
C12P 1934

US Classification:

422 681

Abstract:

A disposable cartridge for storage and delivery of reagents for synthesizing and labeling of synthetic oligonucleotides comprises an annular casing, an enclosed area defined by the interior surface of the casing and a non-swellable matrix which is inert to organic solvents is positioned within the enclosed area. Adsorbed onto the surface of the matrix is a reagent to be coupled to an immobilized oligonucleotide precursor. The cartridges can be packaged in such a way as to insure the long-term stability of the reagents contained therein. The cartridge is readily insertable into the reagent delivery line of an automated synthesizer of oligonucleotides and also is useful for the production of labeled oligonucleotides by manual coupling. The cartridges of the invention are disposable after a single use. Substantial economies in the synthesis of labeled synthetic oligonucleotides are achieved by use of the cartridge.

US Patent:

20220401563, Dec 22, 2022

Filed:

Jul 14, 2022

Appl. No.:

17/812607

Inventors:

- Duarte CA, US
Piotr Marek Swiderski - San Dimas CA, US
Dayson Friaca Moreira - Duarte CA, US

International Classification:

A61K 47/54
A61K 45/06
A61K 31/713
C12N 15/113
A61P 37/00
A61P 35/02
A61P 35/00

Abstract:

The present disclosure relates to an isolated compound including a phosphorothioated oligodeoxynucleotide (ODN) sequence conjugated to a short-activating RNA (saRNA) or an antisense oligonucleotide sequence (ASO), compositions of such a compound, and method of treatment of cancer and autoimmune diseases (with or without stimulating an immune response), method of immune stimulation, method of activating CEBPA, and method of reducing activity of STAT transcription factor, by one of the disclosed compounds or compositions.