Keith C Deen

US Patent:

6660839, Dec 9, 2003

Filed:

May 19, 1999

Appl. No.:

09/314844

Inventors:

Keith Charles Deen - Glenmoore PA
Mark R. Hurle - Norristown PA
Peter Young - Lawrenceville NJ
Kong B. Tan - Philadelphia PA

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

A61K 3800

US Classification:

530350, 53038824, 530300, 514 2

Abstract:

TR7 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing TR7 polypeptides and polynucleotides in the design of protocols for the treatment of chronic and acute inflammation, arthritis, septicemia, autoimmune diseases (such as inflammatory bowel disease and psoriasis), transplant rejection, graft versus host disease, infection, stroke, ischemia, acute respiratory disease syndrome, restenosis, brain injury, AIDS, bone diseases, cancer (such as lymphoproliferative disorders), atherosclerosis, and Alzheimers disease, among others and diagnostic assays for such conditions.

US Patent:

7049422, May 23, 2006

Filed:

Sep 15, 2003

Appl. No.:

10/663157

Inventors:

Keith Charles Deen - Glenmoore PA, US
Mark R. Hurle - Norristown PA, US
Peter Young - Lawrenceville NJ, US
Kong B. Tan - Philadelphia PA, US

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C12N 15/00
C12N 15/85
C07H 21/04
C07K 119/00

US Classification:

536 232, 435 691, 4353201, 435325, 4352523, 536 231, 536 235, 530350

Abstract:

TR7 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing TR7 polypeptides and polynucleotides in the design of protocols for the treatment of chronic and acute inflammation, arthritis, septicemia, autoimmune diseases (such as inflammatory bowel disease and psoriasis), transplant rejection, graft versus host disease, infection, stroke, ischemia, acute respiratory disease syndrome, restenosis, brain injury, AIDS, bone diseases, cancer (such as lymphoproliferative disorders), atherosclerosis, and Alzheimers disease, among others and diagnostic assays for such conditions.

US Patent:

20010010924, Aug 2, 2001

Filed:

Aug 22, 1997

Appl. No.:

08/916625

Inventors:

KEITH CHARLES DEEN - GLENMOORE PA, US
PETER RONALD YOUNG - LAWRENCEVILLE NJ, US

International Classification:

A01N037/18
A61K038/00
G01N033/53
C12Q001/68
G01N033/567
C07H021/04
C12P021/06
C07K005/00
C07K007/00
C07K016/00

US Classification:

435/069100, 435/325000, 435/007200, 514/002000, 435/006000, 530/387900, 530/324000, 536/023500

Abstract:

TR6 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing TR6 polypeptides and polynucleotides in the design of protocols for the treatment of chronic and acute inflammation, arthritis, septicemia, autoimmune diseases (e.g. inflammatory bowel disease, psoriasis), transplant rejection, graft vs. host disease, infection, stroke, ischemia, acute respiratory disease syndrome, restenosis, brain injury, AIDS, Bone diseases, cancer (e.g. lymphoproliferative disorders), atheroschlerosis, and Alzheimers disease., among others and diagnostic assays for such conditions.

US Patent:

20020141990, Oct 3, 2002

Filed:

Feb 4, 2002

Appl. No.:

10/066895

Inventors:

Keith Deen - Glenmoore PA, US
Susan Dillon - Chester Springs PA, US
Terence Porter - Berwyn PA, US
Raymond Sweet - Bala Cynwyd PA, US

Assignee:

SmithKline Beecham Corporation

International Classification:

A61K039/395
C07K016/08
C07H021/04
C12N005/06
C12P021/02

US Classification:

424/133100, 530/388150, 435/326000, 435/069100, 536/023530

Abstract:

This invention relates to novel human monoclonal antibodies (mAbs) and to the genes encoding same. More specifically, this invention relates to human monoclonal antibodies specifically reactive with an epitope of the fusion (F) protein of Respiratory Syncytial Virus (RSV). Such antibodies are useful for the therapeutic and/or prophylactic treatment of RSV infection in human patients, particularly infants and young children.

US Patent:

20050019758, Jan 27, 2005

Filed:

Jul 9, 2004

Appl. No.:

10/887954

Inventors:

Keith Deen - Glenmoore PA, US
Susan Dillon - Chester Springs PA, US
Terence Porter - Berwyn PA, US
Raymond Sweet - Cynwyd PA, US

International Classification:

C12Q001/70
C07H021/04
C12N005/06

US Classification:

435005000, 435069100, 435320100, 435339000, 530388300, 536023530

Abstract:

This invention relates to novel human monoclonal antibodies (mAbs) and to the genes encoding same. More specifically, this invention relates to human monoclonal antibodies specifically reactive with an epitope of the fusion (F) protein of Respiratory Syncytial Virus (RSV). Such antibodies are useful for the therapeutic and/or prophylactic treatment of RSV infection in human patients, particularly infants and young children.

US Patent:

60134763, Jan 11, 2000

Filed:

Oct 28, 1997

Appl. No.:

8/959382

Inventors:

Keith Charles Deen - Glenmoore PA
Mark R. Hurle - Norristown PA
Peter Young - Lawrenceville NJ
K. B. Tan - Philadelphia PA

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C12N 1509
C12N 1500

US Classification:

435 691

Abstract:

TR7 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing TR7 polypeptides and polynucleotides in the design of protocols for the treatment of chronic and acute inflammation, arthritis, septicemia, autoimmune diseases (such as inflammatory bowel disease and psoriasis), transplant rejection, graft versus host disease, infection, stroke, ischemia, acute respiratory disease syndrome, restenosis, brain injury, AIDS, bone diseases, cancer (such as lymphoproliferative disorders), atherosclerosis, and Alzheimers disease, among others and diagnostic assays for such conditions.