Karla Kirkegaard - Palo Alto CA, US Kathy Richmond - Mountain View CA, US John Lyle - Palo Alto CA, US Steve Schultz - Tsaile AZ, US Scott Hobson - Schriesheim, DE
International Classification:
A61K039/12 C12Q001/70
US Classification:
424/186100, 530/388300, 435/005000
Abstract:
The present invention provides a viral RNA-dependent RNA polymerase pharmacophore which is characterized by binding to a conserved interface binding surfaces of a viral RNA-dependent RNA polymerase.
Viral Vectors Useful In Induction Of Humoral Or Cellular Immunity
Karla Kirkegaard - Palo Alto CA, US Dana Dodd - Palo Alto CA, US Stephen Deitz - Redwood City CA, US John Doedens - Seattle WA, US
International Classification:
A61K048/00 C12N007/00 C12N015/86
US Classification:
424/093200, 435/456000, 435/235100
Abstract:
The invention features recombinant viral vectors that take advantage of the activity of picornaviral protein 3A in modulating cytokine secretion and antigen presentation on MHC Class (MHC I), which in turn provides for modulation of a Th1-mediated immune response to the transfected host cell. Specifically, a recombinant viral vector comprising a sequence encoding picornaviral protein 3A provides for decreased antigen presentation on MHC 1 and a decreased incidence of Th1-mediated immune response, while a recombinant picornaviral vector that is deficient in protein 3A production provides for increased cytokine secretion, increased antigen presentation on MHC and increased Th1-mediated immune response towards the transfected host cell. The invention also features methods of inducing humoral or cellular immunity using the vectors.
For this reason, antiviral drugs must be extremely targeted and specific, said Stanford virologist Karla Kirkegaard. They tend to target proteins produced by the virus (using our cellular machinery) as part of its replication process. These proteins are unique to their viruses. This means the drugs
Date: Mar 23, 2020
Category: Health
Source: Google
Stanford to develop next-gen vaccines with $50M grant from Gates foundation
achford and Carlota A. Harris Professor, also in the Department of Microbiology and Immunology; Atul Butte, associate professor of pediatrics and genetics and, by courtesy, computer science; Yvonne Maldonado, professor of pediatrics and of health policy and research; Karla Kirkegaard, the Violetta L.
Date: Jan 31, 2015
Category: Health
Source: Google
MIT Scientists Develop a Drug to Fight Any Viral Infection
"Viruses are pretty good at developing resistance to things we try against them, but in this case, it's hard to think of a simple pathway to drug resistance," said Karla Kirkegaard, professor of microbiology and immunology at Stanford University.
Combining those two elements is a great idea and a very novel approach, says Karla Kirkegaard, professor of microbiology and immunology at Stanford University. Viruses are pretty good at developing resistance to things we try against them, but in this case, its hard to think of a simple pathway