Robert A. Kirken - El Paso TX, US Barry D. Kahan - Houston TX, US Stanislaw M. Stepkowski - Pearland TX, US Waldemar Priebe - Houston TX, US Izabela Fokt - Spring TX, US Szymon Kosinski - Menomonee Falls WI, US
Assignee:
Board of Regents of the University of Texas System - Austin TX
International Classification:
A61K 38/00 A61K 31/12 A61K 31/13 A01N 35/00
US Classification:
514 11, 514690, 514659
Abstract:
Methods are disclosed for inhibiting or disrupting Janus tyrosine kinase 3 (Jak3) dependent function in cells of lymphoid or myeloid origin, especially for blocking proliferation and function of lymphocytes (e. g. , T-cells, B-cells). A Mannich base compound, or a derivative or modified compound, is employed which is capable of selectively inhibiting Jak3 while affecting other protein tyrosine kinase activities to a lesser extent or not at all, to provide beneficial effects such as mitigation of transplant rejection and alleviation of allergic responses with fewer side effects than with conventional immunosuppressive agents.
Methods For Selectively Inhibiting Janus Tyrosine Kinase 3 (Jak3)
Robert A. Kirken - Conroe TX, US Barry D. Kahan - Houston TX, US Stanislaw M. Stepkowski - Pearland TX, US Waldemar Priebe - Houston TX, US Izabela Fokt - Spring TX, US Szymon Kosinski - Menomonee Falls WI, US
Assignee:
Board of Regents, The University of Texas System - Austin TX
International Classification:
A61K 31/21 A61K 31/13 A61K 31/12 A61K 8/73
US Classification:
514513, 514 80, 514690, 514659, 424 49
Abstract:
Methods are disclosed for inhibiting or disrupting Janus tyrosine kinase 3 (Jak3) dependent function in cells of lymphoid or myeloid origin, especially for blocking proliferation and function of lymphocytes (e. g. , T-cells, B-cells). A Mannich base compound, or a derivative or modified compound, is employed which is capable of selectively inhibiting Jak3 while affecting other protein tyrosine kinase activities to a lesser extent or not at all, to provide beneficial effects such as mitigation of transplant rejection and alleviation of allergic responses with fewer side effects than with conventional immunosuppressive agents.
Robert Kirken - El Paso TX, US Eric MacDonald - El Paso TX, US Ryan Wicker - El Paso TX, US Kristin Gosselink - El Paso TX, US
Assignee:
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM - Austin TX
International Classification:
G01N 33/53
US Classification:
422 69
Abstract:
The present invention provides a sensor for the detection of chemical agents in real time. The sensor includes a sample region having a detector disposed about a substrate where a chemical agent binds to the detector to generate in a signal. The sensor includes a microcontroller in communication with the detector, an analog to digital converter, and a communication module to process the signal into an analytical signal. In addition, the sensor includes an antenna in communication with the microcontroller to enable a wireless communication network, wherein the analytical signal can be transmitted and a power source in operable communication with the microcontroller to supply a source of power to the sensor.
Robert Kirken - El Paso TX, US Georgialina Rodriguez - El Paso TX, US
Assignee:
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM - Austin TX
International Classification:
A61K 39/395 A61P 35/00
Abstract:
Embodiments are directed to therapeutic antibodies or antibody fragments that relieve suppression of the immune system, as well therapeutic methods using the same.
Ctla-4 Blockade With Metronomic Chemotherapy For The Treatment Of Cancer
Mitchell S. Felder - Hermitage PA, US Giulio Francia - El Paso TX, US Robert Arthur Kirken - El Paso TX, US
International Classification:
A61K 39/395 A61K 31/7068 A61K 31/675
Abstract:
The present invention is directed to methods for treating cancer by administering an anti-CTLA-4 agent in combination with a metronomic chemotherapy or a sequential chemotherapy.
Name / Title
Company / Classification
Phones & Addresses
Robert Kirken Chairman
Department of Biological Science of Uiversity of Texa Alpaso Medical Laboratory
500 W University Ave, El Paso, TX 79968 915 747-5844
Resumes
Dean Of College Of Science Chemistry Computer Science Building
The University of Texas at El Paso 2005 - May 2013
Professor and Chair-Biological Sciences
The University of Texas at El Paso 2005 - May 2013
Dean of College of Science Chemistry Computer Science Building
Education:
Wright State University 1986 - 1991
Skills:
Science Higher Education Molecular Biology Research Animal Models University Teaching Teaching Cell Culture Microscopy Cell Biology Biochemistry Immunology Statistics Grant Writing Public Speaking Genetics Cell Confocal Microscopy Western Blotting Student Affairs Bioinformatics Flow Cytometry Tissue Culture Experimental Design Microbiology Theory Student Development Lifesciences Data Analysis Protein Chemistry Pcr Spectroscopy Genomics Protein Purification Program Development Cancer Program Evaluation Apoptosis Public Health Distance Learning Instructional Design Neuroscience Curriculum Design Physics Curriculum Development Mathematical Modeling Spss Nanotechnology Matlab Biotechnology
News
UTEP team develops low-cost device for rapid cancer detection
Dr. XiuJun Li's innovation significantly improves point-of-care diagnostics by reducing detection times and the need for costly instruments, said Robert Kirken, dean of the College of Science. This makes it ideal for resource-limited settings, which will improve early diagnosis and lead to better
Date: Oct 26, 2024
Category: Health
Source: Google
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