Jing Z Ma

US Patent:

20040146509, Jul 29, 2004

Filed:

Jul 23, 2003

Appl. No.:

10/626004

Inventors:

Zhihe Li - Foster City CA, US
David Liu - Palo Alto CA, US
Jing Ma - Cupertino CA, US
Andrew Protter - Palo Alto CA, US
George Schreiner - Los Altos CA, US

International Classification:

A61K039/395

US Classification:

424/144100

Abstract:

The invention concerns methods for improvement of lung function by administering non-peptide small molecule inhibitors of TGF- specifically binding to the type I TGF- receptor (TGF-R1). Preferably, the inhibitors are quinazoline derivatives.

US Patent:

20210017120, Jan 21, 2021

Filed:

Sep 29, 2020

Appl. No.:

17/036588

Inventors:

- Taipei City, TW
Yeyu Cao - South San Francisco CA, US
Xiaohong Cai - South San Francisco CA, US
Hailong Jiao - South San Francisco CA, US
Jing Yuan Ma - South San Francisco CA, US
Mark Matteucci - South San Francisco CA, US

Assignee:

OBI PHARMA, INC. - Taipei City

International Classification:

C07C 217/58
C07D 405/12
C07F 9/6558
A61K 47/64
C07D 403/06
A61K 47/55
A61P 35/00
C07D 239/94
C07D 487/04
C07D 471/04
C07C 213/02
C07D 491/22
C07H 19/06

Abstract:

Provided herein are compounds of formula I:wherein the variables are defined herein, processes of making them, and methods of treating cancer comprising administering such compounds.

US Patent:

20190225633, Jul 25, 2019

Filed:

Mar 28, 2019

Appl. No.:

16/368753

Inventors:

- Taipei City, TW
Yeyu Cao - South San Francisco CA, US
Xiaohong Cai - South San Francisco CA, US
Hailong Jiao - South San Francisco CA, US
Jing Yuan Ma - South San Francisco CA, US
Mark Matteucci - South San Francisco CA, US

Assignee:

OBI PHARMA, INC. - Taipei City

International Classification:

C07F 9/24
G01N 33/574
A61K 31/396

Abstract:

Provided herein are compounds of formula I:wherein the variables are defined herein, processes of making them, and methods of treating cancer comprising administering such compounds.

US Patent:

20180258116, Sep 13, 2018

Filed:

Nov 15, 2016

Appl. No.:

15/752854

Inventors:

- Taipei City, TW
Yeyu Cao - South San Francisco CA, US
Xiaohong Cai - South San Francisco CA, US
Hailong Jiao - South San Francisco CA, US
Jing Yuan Ma - South San Francisco CA, US
Mark Matteucci - South San Francisco CA, US

Assignee:

OBI Pharma, Inc. - Taipei City

International Classification:

C07F 9/564
A61P 35/00

Abstract:

Provided herein are optically active compounds of the formulae (ii); and (III) and pharmaceutical compositions thereof. Also provided herein are processes of making these compounds and resolving the racemic mixture or the enrichment of same with in one of its enantiomers to provide (R)- and (S)-1-(3-(3-N,N-dimethylaminocarbonyl)phenoxyl-4-nitrophenyl)-1-ethyl-N,N′-bis(ethylene)phosphoramidate, and methods of treating cancer comprising administering such compounds.

US Patent:

20180169064, Jun 21, 2018

Filed:

Jun 23, 2016

Appl. No.:

15/736285

Inventors:

- South San Francisco CA, US
Xiaohong Cai - South San Francisco CA, US
Yeyu Cao - South San Francisco CA, US
Hailong Jiao - South San Francisco CA, US
Jing Yuan Ma - South San Francisco CA, US
Jian-Xin Duan - South San Francisco CA, US

International Classification:

A61K 31/396
A61K 31/4168
A61K 31/4178
A61K 31/665
A61K 31/675
A61P 35/00

Abstract:

Provided herein are compounds of formula (I)-(VI), wherein the variables are defined herein, processes of making them, and methods of treating cancer comprising administering such compounds.

US Patent:

20180086693, Mar 29, 2018

Filed:

Apr 1, 2016

Appl. No.:

15/563481

Inventors:

- Taipei City, TW
Yeyu Cao - South San Francisco CA, US
Xiaohong Cai - South San Francisco CA, US
Hailong Jiao - South San Francisco CA, US
Jing Yuan Ma - South San Francisco CA, US
Mark Matteucci - South San Francisco CA, US

Assignee:

OBI PHARMA, INC. - Taipei City

International Classification:

C07C 217/58
C07D 491/22
C07D 405/12
C07C 213/02
C07H 19/06

Abstract:

Provided herein are compounds of formula I, wherein the variables are defined herein, processes of making them, and methods of treating cancer comprising administering such compounds.

US Patent:

20180044360, Feb 15, 2018

Filed:

Mar 9, 2016

Appl. No.:

15/557053

Inventors:

- Taipei City, TW
Yeyu Cao - South San Francisco CA, US
Xiaohong Cai - South San Francisco CA, US
Hailong Jiao - South San Francisco CA, US
Jing Yuan Ma - South San Francisco CA, US
Mark Matteucci - South San Francisco CA, US

Assignee:

OBI PHARMA, INC. - Taipei City

International Classification:

C07F 9/24
G01N 33/574

Abstract:

Provided herein are compounds of formula I: wherein the variables are defined herein, processes of making them, and methods of treating cancer comprising administering such compounds.