Kulsoom Ghias - Chicago IL, US Chunguang Ma - Champaign IL, US Varsha Gandhi - Houston TX, US Leonidas C. Platanias - Glencoe IL, US Nancy L. Krett - Elk Grove Village IL, US Steven T. Rosen - Evanston IL, US
Assignee:
NORTHWESTERN UNIVERSITY - Evanston IL THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM - AUSTIN TX
The present invention provides methods of treating hematological malignancies, including multi-drug resistant malignancies, with 8-amino-adenosine and variants thereof. Also encompassed by the present invention is a method of predicting the response of a patient diagnosed with a hematological malignancy to treatment with a nucleoside analog and a method of screening candidate drugs for efficacy in treating hematological malignancies.
Paul Collodi - West Lafayette IN, US Lianchun Fan - West Lafayette IN, US Chunguang Ma - Hoffman Estates IL, US
Assignee:
Purdue Research Foundation - West Lafayette IN
International Classification:
A01K067/027 C12N005/06
US Classification:
800/020000, 435/325000
Abstract:
The present invention is directed to methods of making a fish embryo cell line that can give rise to germ cells when introduced to a fish embryo. The present invention is further directed to methods of using the fish embryo cell line, making germ line chimeric fish, and to a cell culture medium.