The invention concerns antibodies which is specific for SM5-1 antigen expressed in melanoma, breast cancer and hepatocellular carcinoma, and polynucleotides encoding the antibodies. The invention further concerns use of such antibodies and/or polynucleotides in diagnosing and treating malignancies.
Preparation And Application Of Anti-Tumor Bifunctional Fusion Proteins
Jing Ma - Laguna Niguel CA, US Yanjun Guo - Shanghai, CN
International Classification:
A61K039/00 C07K014/82
US Classification:
424185100, 530350000
Abstract:
Provided herein is a chimeric protein, which chimeric protein comprises a Flt3 ligand, or a biologically active fragment thereof, and a proteinaceous or peptidyl tumoricidal agent, or a targeting agent which binds to a receptor expressed on a tumor, and uses thereof, particularly in the treatment of malignancy. Other embodiments and uses are disclosed.
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Jing Ma
Education:
Friedrich Schiller University of Jena - Volkswirtschaftslehre