Zhihe Li - Foster City CA, US David Liu - Palo Alto CA, US Jing Ma - Cupertino CA, US Andrew Protter - Palo Alto CA, US George Schreiner - Los Altos CA, US
International Classification:
A61K039/395
US Classification:
424/144100
Abstract:
The invention concerns methods for improvement of lung function by administering non-peptide small molecule inhibitors of TGF- specifically binding to the type I TGF- receptor (TGF-R1). Preferably, the inhibitors are quinazoline derivatives.
Preparation And Application Of Anti-Tumor Bifunctional Fusion Proteins
Provided herein is a chimeric protein, which chimeric protein comprises a Flt3 ligand, or a biologically active fragment thereof, and a proteinuous or peptidyl tumoricidal agent, and uses thereof, particularly in the treatment of malignancy.
Antibodies Specific For Cancer Associated Antigen Sm5-1 And Uses Thereof
Jing Ma - San Diego CA, US Yajun Guo - Shanghai, CN
International Classification:
A61K039/395 C07K016/40
US Classification:
424146100, 530388260
Abstract:
The invention concerns antibodies which is specific for SM5-1 antigen expressed in melanoma, breast cancer and hepatocellular carcinoma, and polynucleotides encoding the antibodies. The invention further concerns use of such antibodies and/or polynucleotides in diagnosing and treating malignancies.
- Taipei City, TW Yeyu Cao - South San Francisco CA, US Xiaohong Cai - South San Francisco CA, US Hailong Jiao - South San Francisco CA, US Jing Yuan Ma - South San Francisco CA, US Mark Matteucci - South San Francisco CA, US
Provided herein are compounds of formula I:wherein the variables are defined herein, processes of making them, and methods of treating cancer comprising administering such compounds.
- Taipei City, TW Yeyu Cao - South San Francisco CA, US Xiaohong Cai - South San Francisco CA, US Hailong Jiao - South San Francisco CA, US Jing Yuan Ma - South San Francisco CA, US Mark Matteucci - South San Francisco CA, US
Assignee:
OBI PHARMA, INC. - Taipei City
International Classification:
C07F 9/24 G01N 33/574 A61K 31/396
Abstract:
Provided herein are compounds of formula I:wherein the variables are defined herein, processes of making them, and methods of treating cancer comprising administering such compounds.
(R)- And (S)-1-(3-(3-N,N-Dimethylaminocarbonyl)Phenoxyl-4-Nitrophenyl)-1-Ethyl-N,N'-Bis (Ethylene)Phosphoramidate, Compositions And Methods For Their Use And Preparation
- Taipei City, TW Yeyu Cao - South San Francisco CA, US Xiaohong Cai - South San Francisco CA, US Hailong Jiao - South San Francisco CA, US Jing Yuan Ma - South San Francisco CA, US Mark Matteucci - South San Francisco CA, US
Assignee:
OBI Pharma, Inc. - Taipei City
International Classification:
C07F 9/564 A61P 35/00
Abstract:
Provided herein are optically active compounds of the formulae (ii); and (III) and pharmaceutical compositions thereof. Also provided herein are processes of making these compounds and resolving the racemic mixture or the enrichment of same with in one of its enantiomers to provide (R)- and (S)-1-(3-(3-N,N-dimethylaminocarbonyl)phenoxyl-4-nitrophenyl)-1-ethyl-N,N′-bis(ethylene)phosphoramidate, and methods of treating cancer comprising administering such compounds.
- South San Francisco CA, US Xiaohong Cai - South San Francisco CA, US Yeyu Cao - South San Francisco CA, US Hailong Jiao - South San Francisco CA, US Jing Yuan Ma - South San Francisco CA, US Jian-Xin Duan - South San Francisco CA, US
Provided herein are compounds of formula (I)-(VI), wherein the variables are defined herein, processes of making them, and methods of treating cancer comprising administering such compounds.
- Taipei City, TW Yeyu Cao - South San Francisco CA, US Xiaohong Cai - South San Francisco CA, US Hailong Jiao - South San Francisco CA, US Jing Yuan Ma - South San Francisco CA, US Mark Matteucci - South San Francisco CA, US
Provided herein are compounds of formula I, wherein the variables are defined herein, processes of making them, and methods of treating cancer comprising administering such compounds.