Jennifer Ya Chen Tsai

US Patent:

20190095578, Mar 28, 2019

Filed:

Sep 24, 2018

Appl. No.:

16/139699

Inventors:

- Menlo Park CA, US
Jue Fan - Menlo Park CA, US
Jennifer Tsai - Menlo Park CA, US

International Classification:

G06F 19/24
G06F 19/22
G06F 19/28
C12Q 1/6869
C12Q 1/6876
G06F 17/18

Abstract:

Disclosed herein are methods and systems for determining occurrences of targets. In some embodiments, the method comprises: collapsing putative sequences of the target; collapsing molecular label sequences associated with the putative sequences of the target; and estimating the occurrence of the target, wherein the occurrence of the target estimated correlates with the occurrence of molecular label sequences associated with the putative sequences of the target in the sequencing data after collapsing the occurrence of the putative sequences of the target and the occurrence of noise molecular label sequences.

US Patent:

20170344866, Nov 30, 2017

Filed:

May 25, 2017

Appl. No.:

15/605874

Inventors:

- Menlo Park CA, US
Jennifer Tsai - Menlo Park CA, US
Eleen Shum - Menlo Park CA, US
Lisha Deng - Menlo Park CA, US
Glenn K. Fu - Menlo Park CA, US

International Classification:

G06K 19/06

Abstract:

Disclosed herein are methods and systems for determining the numbers of targets. In some embodiments, the method comprise: stochastically barcoding targets using stochastic barcodes; obtaining sequencing data; for one or more of the targets: counting the number of molecular labels with distinct sequences associated with the target in the sequencing data; identifying clusters of molecular labels of the target using directional adjacency; collapsing the sequencing data using the clusters of molecular labels of the target identified; and estimating the number of the target.