Jing Wu - San Mateo CA Jay S. Tung - Belmont CA Eugene D. Thorsett - Moss Beach CA Jon K. Reel - Carmel IN Warren J. Porter - Indianapolis IN Jeffrey S. Nissen - Indianapolis IN Thomas E. Mabry - Indianapolis IN Lee H. Latimer - Oakland CA Varghese John - San Francisco CA Beverly K. Folmer - Newark DE James J. Droste - Indianapolis IN Thomas C. Britton - Carmel IN James E. Audia - Indianapolis IN
Assignee:
Elan Pharmaceuticals, Inc. - South San Francisco CA Eli Lilly Company - Indianapolis IN
Disclosed are compounds which inhibit -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimers disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits -amyloid peptide release and/or its synthesis.
Cycloalkyl, Lactam, Lactone And Related Compounds, Pharmaceutical Compositions Comprising Same, And Methods For Inhibiting -Amyloid Peptide Release And/Or Its Synthesis By Use Of Such Compounds
Jing Wu - San Mateo CA Jay S. Tung - Belmont CA Eugene D. Thorsett - Moss Beach CA Michael A. Pleiss - Sunnyvale CA Jeffrey S. Nissen - Indianapolis IN R. Jeffrey Neitz - San Francisco CA Lee H. Latimer - Oakland CA Varghese John - San Francisco CA Stephen Freedman - Walnut Creek CA Thomas C. Britton - Carmel IN James A. Audia - Indianapolis IN Jon K. Reel - Carmel IN Thomas E. Mabry - Indianapolis IN Bruce A. Dressman - Indianapolis IN Cynthia L. Cwi - Indianapolis IN James J. Droste - Indianapolis IN Steven S. Henry - New Palestine IN Stacey L. McDaniel - Indianapolis IN William Leonard Scott - Indianapolis IN Russell D. Stucky - Indianapolis IN Warren J. Porter - Indianapolis IN
Assignee:
Athena Neurosciences, Inc. - South San Francisco CA Eli Lilly Company - Indianapolis IN
Disclosed are compounds which inhibit -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimers disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits -amyloid peptide release and/or its synthesis as well as methods for treating Alzheimers disease both prophylactically and therapeutically with such pharmaceutical compositions.
Cycloalkyl, Lactam, Lactone And Related Compounds, Pharmaceutical Compositions Comprising Same, And Methods For Inhibiting -Amyloid Peptide Release And/Or Its Synthesis By Use Of Such Compounds
Jing Wu - San Mateo CA Jay S. Tung - Belmont CA Eugene D. Thorsett - Moss Beach CA Michael A. Pleiss - Sunnyvale CA Jeffrey S. Nissen - Indianapolis IN R. Jeffrey Neitz - San Francisco CA Lee H. Latimer - Oakland CA Varghese John - San Francisco CA Stephen Freedman - Walnut Creek CA Thomas C. Britton - Carmel IN James A. Audia - Indianapolis IN Jon K. Reel - Carmel IN Thomas E. Mabry - Indianapolis IN Bruce A. Dressman - Indianapolis IN Cynthia L. Cwi - Indianapolis IN James J. Droste - Indianapolis IN Steven S. Henry - New Palestine IN Stacey L. McDaniel - Bloomington IN William Leonard Scott - Indianapolis IN Russell D. Stucky - Indianapolis IN Warren J. Porter - Indianapolis IN
Assignee:
Athena Neurosciences, Inc. - South San Francisco CA Eli Lilly Company - Indianapolis IN
Disclosed are compounds which inhibit -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimers disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits -amyloid peptide release and/or its synthesis as well as methods for treating Alzheimers disease both prophylactically and therapeutically with such pharmaceutical compositions.
Cycloalkyl, Lactam, Lactone And Related Compounds, Pharmaceutical Compositions Comprising Same, And Methods For Inhibiting -Amyloid Peptide Release And/Or Its Synthesis By Use Of Such Compounds
Jing Wu - San Mateo CA Jay S. Tung - Belmont CA Eugene D. Thorsett - Moss Beach CA Michael A. Pleiss - Sunnyvale CA Jeffrey S. Nissen - Indianapolis IN R. Jeffrey Neitz - San Francisco CA Lee H. Latimer - Oakland CA Varghese John - San Francisco CA Stephen Freedman - Walnut Creek CA Thomas C. Britton - Carmel IN James A. Audia - Indianapolis IN Jon K. Reel - Carmel IN Thomas E. Mabry - Indianapolis IN Bruce A. Dressman - Indianapolis IN Cynthia L. Cwi - Indianapolis IN James J. Droste - Indianapolis IN Steven S. Henry - New Palestine IN Stacey L. McDaniel - Indianapolis IN William Leonard Scott - Indianapolis IN Russell D. Stucky - Indianapolis IN Warren J. Porter - Indianapolis IN
Assignee:
Athena Neurosciences, Inc. - South San Francisco CA Eli Lilly Company - Indianapolis IN
Disclosed are compounds which inhibit -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimers disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits -amyloid peptide release and/or its synthesis as well as methods for treating Alzheimers disease both prophylactically and therapeutically with such pharmaceutical compositions.
Cycloalkyl, Lactam, Lactone And Related Compounds, Pharmaceutical Compositions Comprising Same, And Methods For Inhibiting -Amyloid Peptide Release And/Or Its Synthesis By Use Of Such Compounds
Jing Wu - San Mateo CA Jay S. Tung - Belmont CA Eugene D. Thorsett - Moss Beach CA Michael A. Pleiss - Sunnyvale CA Jeffrey S. Nissen - Indianapolis IN Jeffrey Neitz - San Francisco CA Lee H. Latimer - Oakland CA Varghese John - San Francisco CA Stephen Freedman - Walnut Creek CA Thomas C. Britton - Carmel IN James A. Audia - Indianapolis IN Jon K. Reel - Carmel IN Thomas E. Mabry - Indianapolis IN Bruce A. Dressman - Indianapolis IN James J. Droste - Indianapolis IN Steven S. Henry - New Palestine IN Stacey L. McDaniel - Indianapolis IN Russell D. Stucky - Indianapolis IN Warren J. Porter - Indianapolis IN
Assignee:
Athena Neurosciences, Inc. - South San Francisco CA Eli Lilly Company - Indianapolis IN
Disclosed are compounds which inhibit -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimers disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits -amyloid peptide release and/or its synthesis as well as methods for treating Alzheimers disease both prophylactically and therapeutically with such pharmaceutical compositions.
John P. Anderson - San Francisco CA Guriqbal Basi - Palo Alto CA Minh Tam Doan - Hayward CA Normand Frigon - Milbrae CA Varghese John - San Francisco CA Michael Power - Fremont CA Sukanto Sinha - San Francisco CA Gwen Tatsuno - Oakland CA Jay Tung - Belmont CA Shuwen Wang - Hersey PA Lisa McConlogue - Burlingame CA
Assignee:
Elan Pharmaceuticals, Inc. - South San Francisco CA
International Classification:
C07K 1640
US Classification:
5303879, 5303881, 53038826, 5303891, 5303892
Abstract:
Disclosed are various forms of an active, isolated -secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimers disease. Recombinant cells that produce this enzyme either alone or in combination with some of its natural substrates (-APPwt and -APPsw) are also disclosed, as are antibodies directed to such proteins. These compositions are useful for use in methods of selecting compounds that modulate -secretase. Inhibitors of -secretase are implicated as therapeutics in the treatment of neurodegenerative diseases, such as Alzheimers disease.
Cycloalkyl, Lactam, Lactone And Related Compounds, Pharmaceutical Compositions Comprising Same, And Methods For Inhibiting -Amyloid Peptide Release And/Or Its Synthesis By Use Of Such Compounds
Jing Wu - San Mateo CA Jay S. Tung - Belmont CA Eugene D. Thorsett - Moss Beach CA Michael A. Pleiss - Sunnyvale CA Jeffrey S. Nissen - Indianapolis IN R. Jeffrey Neitz - San Francisco CA Lee H. Latimer - Oakland CA Varghese John - San Francisco CA Stephen Freedman - Walnut Creek CA Thomas C. Britton - Carmel IN James A. Audia - Indianapolis IN Jon K. Reel - Carmel IN Thomas E. Mabry - Indianapolis IN Bruce A. Dressman - Indianapolis IN Cynthia L. Cwi - Indianapolis IN James J. Droste - Indianapolis IN Steven S. Henry - New Palestine IN Stacey L. McDaniel - Bloomington IN William Leonard Scott - Indianapolis IN Russell D. Stucky - Indianapolis IN Warren J. Porter - Indianapolis IN
Assignee:
Athena Neurosciences, Inc. - South San Francisco CA Eli Lilly Company - Indianapolis IN
International Classification:
A61K 3155
US Classification:
514220, 514221
Abstract:
Disclosed are compounds which inhibit -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimers disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits -amyloid peptide release and/or its synthesis as well as methods for treating Alzheimers disease both prophylactically and therapeutically with such pharmaceutical compositions.
Cycloalkyl, Lactam, Lactone And Related Compounds, Pharmaceutical Compositions Comprising Same, And Methods For Inhibiting -Amyloid Peptide Release And/Or Its Synthesis By Use Of Such Compounds
Jing Wu - San Mateo CA Jay S. Tung - Belmont CA Eugene D. Thorsett - Moss Beach CA Michael A. Pleiss - Sunnyvale CA Jeffrey S. Nissen - Indianapolis IN R. Jeffrey Neitz - San Francisco CA Lee H. Latimer - Oakland CA Varghese John - San Francisco CA Stephen Freedman - Walnut Creek CA Thomas C. Britton - Carmel IN James A. Audia - Indianapolis IN Jon K. Reel - Carmel IN Thomas E. Mabry - Indianapolis IN Bruce A. Dressman - Indianapolis IN Cynthia L. Cwi - Indianapolis IN James J. Droste - Indianapolis IN Steven S. Henry - New Palestine IN Stacey L. McDaniel - Indianapolis IN William Leonard Scott - Indianapolis IN Russell D. Stucky - Indianapolis IN Warren J. Porter - Indianapolis IN
Assignee:
Athena Neurosciences, Inc. - South San Francisco CA Eli Lilly Company - Indianapolis IN
International Classification:
A61K 3155
US Classification:
51421203, 51421204, 51421207, 51421208
Abstract:
Disclosed are compounds which inhibit -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimers disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits -amyloid peptide release and/or its synthesis as well as methods for treating Alzheimers disease both prophylactically and therapeutically with such pharmaceutical compositions.
News
Tapping UCSF Invention, Roche and Versant Dive Into Myelin Repair
Jonahs done a great job, said Jay Tung, chief research officer of the Myelin Repair Foundation in Saratoga, CA, which has worked with Chan in the past. We are ecstatic about pharma, academics, startups, anyone moving the field forward. This is exactly what we want to see.
Date: Jun 23, 2014
Category: Health
Source: Google
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