Stuart L. Schreiber - Boston MA, US Scott M. Sternson - New York NY, US Jason C. Wong - Cambridge MA, US Christina M. Grozinger - Urbana IL, US Stephen J. Haggarty - Somerville MA, US Kathryn M. Koeller - Seattle WA, US
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
C07D 309/00 A01N 43/02
US Classification:
549356, 549200, 549357, 514449, 514451, 514452
Abstract:
In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I):and pharmaceutically acceptable derivatives thereof, wherein R, R, R, n, X and Y are as defined herein. The present invention also provides pharmaceutical compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier. The present invention further provides compounds capable of inhibiting histone deacetylatase activity and methods for treating disorders regulated by histone deacetylase activity (e. g. , cancer and protozoal infections) comprising administering a therapeutically effective amount of a compound of formula (I) to a subject in need thereof. The present invention additionally provides methods for modulating the glucose-sensitive subset of genes downstream of Ure2p. The present invention also provides methods for preparing compounds of the invention.
Stuart L. Schreiber - Boston MA, US Scott M. Sternson - New York NY, US Jason C. Wong - Cambridge MA, US Christina M. Grozinger - Urbana IL, US Stephen J. Haggarty - Somerville MA, US Kathryn M. Koeller - Seattle WA, US
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
A61K 31/425 C07D 317/00
US Classification:
514452, 549369
Abstract:
In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I):.
In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I): and pharmaceutically acceptable derivatives thereof, wherein R, R, R, n, X and Y are as defined herein. The present invention also provides pharmaceutical compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier. The present invention further provides compounds capable of inhibiting histone deacetylatase activity and methods for treating disorders regulated by histone deacetylase activity (e.g., cancer and protozoal infections) comprising administering a therapeutically effective amount of a compound of formula (1) to a subject in need thereof. The present invention additionally provides methods for modulating the glucose-sensitive subset of genes downstream of Ure2p.
Medicine Doctors
Dr. Jason T Wong, Orinda CA - DC (Doctor of Chiropractic)
Institute Of Orthopedic Surgery & Sports Medicine 249 S Main St STE 5, Barnegat, NJ 08005 609 242-6999 (phone), 609 242-6922 (fax)
Education:
Medical School Des Moines University College of Osteopathic Medicine Graduated: 1991
Procedures:
Arthrocentesis Carpal Tunnel Decompression Hip Replacement Hip/Femur Fractures and Dislocations Joint Arthroscopy Knee Arthroscopy Knee Replacement Lower Arm/Elbow/Wrist Fractures and Dislocations Lower Leg/Ankle Fractures and Dislocations Shoulder Arthroscopy Shoulder Surgery Spinal Surgery Wound Care
Conditions:
Fractures, Dislocations, Derangement, and Sprains Hallux Valgus Internal Derangement of Knee Internal Derangement of Knee Cartilage Intervertebral Disc Degeneration
Languages:
English
Description:
Dr. Wong graduated from the Des Moines University College of Osteopathic Medicine in 1991. He works in Barnegat, NJ and specializes in Orthopaedic Surgery and Orthopedic Sports Medicine. Dr. Wong is affiliated with Southern Ocean Medical Center and Summit Oaks Hospital.
Dr. Wong graduated from the Albert Einstein College of Medicine at Yeshiva University in 2000. He works in Burien, WA and 1 other location and specializes in Family Medicine and Obstetrics & Gynecology. Dr. Wong is affiliated with Tacoma General Hospital and Virginia Mason Medical Center.
Dr. Wong graduated from the University of California, Los Angeles David Geffen School of Medicine in 1990. He works in Redwood City, CA and specializes in Family Medicine.
South Orange County Surgical Medical Group 24411 Health Ctr Dr STE 350, Laguna Hills, CA 92653 949 457-7900 (phone), 949 588-8719 (fax)
Education:
Medical School Univ of Saskatchewan, Coll of Med, Saskatoon, Sask, Canada Graduated: 1998
Languages:
Arabic English Spanish
Description:
Dr. Wong graduated from the Univ of Saskatchewan, Coll of Med, Saskatoon, Sask, Canada in 1998. He works in Laguna Hills, CA and specializes in General Surgery. Dr. Wong is affiliated with Mission Hospital and Saddleback Memorial Medical Center.
Emergency Physicians PittsburghEmergency Physicians Of Pittsburgh 565 Coal Vly Rd, Clairton, PA 15025 412 469-5959 (phone), 412 469-5600 (fax)
Education:
Medical School Washington University School of Medicine Graduated: 2004
Languages:
English Spanish
Description:
Dr. Wong graduated from the Washington University School of Medicine in 2004. He works in Clairton, PA and specializes in Emergency Medicine. Dr. Wong is affiliated with Jefferson Hospital.
Kaiser Permanente Medical GroupKaiser Permanente Medical Center Hospitalist 700 Lawrence Expy, Santa Clara, CA 95051 408 851-1000 (phone), 408 851-7601 (fax)
Education:
Medical School University of Southern California Keck School of Medicine Graduated: 2005
Languages:
English
Description:
Dr. Wong graduated from the University of Southern California Keck School of Medicine in 2005. He works in Santa Clara, CA and specializes in Internal Medicine. Dr. Wong is affiliated with Kaiser Permanente Santa Clara Medical Center.
Mar 2010 to 2000 Lead Email/Tour & Travel Reservationist AgentHornblower Cruises & Events San Francisco, CA May 2009 to Mar 2010 Lead Tour/Travel Liason AgentHornblower Cruises & Events San Francisco, CA Jan 2008 to May 2009 Lead Agent TrainerHornblower Cruises & Events San Francisco, CA Apr 2007 to Jan 2008 ReservationistLombardi Sports San Francisco, CA Oct 2005 to Apr 2007 Technical Running Advisor
Education:
City College of San Francisco Jan 2010 to Jun 2010 Certificate in Criminal JusticeSkyline College Jan 2008 to Jan 2010 Criminal JusticeCity College of San Francisco Jan 2006 to May 2006 Certificate
Toys'R'Us Hayward, CA Nov 2013 to Jan 2014 Front End AssociateSequoyah Community Church Oakland, CA Aug 2013 to Jan 2014 VolunteerVanguard University Costa Mesa, CA Oct 2010 to Apr 2013 GreeterCrista Camp-Miracle Ranch Port Orchard, WA Jun 2011 to Aug 2011 Store ClerkNorthwest University Kirkland, WA Sep 2008 to May 2009 Student Worker
Education:
Vanguard University-Costa Mesa Costa Mesa, CA 2013 Bachelor of Arts
May 2008 to 2000 Men's Flex Sales StylistEquinox San Francisco, CA Feb 2012 to Mar 2014 Northern California Area ManagerSaks 5th Avenue, Flagship San Francisco, CA Nov 2007 to May 2008 Sales AssociateAbercrombie & Fitch, Market Street Flagship San Francisco, CA Jun 2004 to Oct 2007 Assistant Store, Visual, and Impact Manager
Education:
California State University Hayward, CA 2004 Bachelor of Arts in Sociology
Apr 2008 to 2000 Employer accountingLindquist San Ramon, CA Jun 2009 to Oct 2009 Payroll AuditorAccounts Receivable at Dreyer's Ice Cream Oakland, CA Jul 2007 to Apr 2008 Accounts Receivable SpecialistCompass Financial Solutions Oakland, CA Oct 2006 to Jul 2007 Billing Clerk
Education:
University of California Davis Davis, CA Sep 2001 to Jun 2005 Bachelor of Arts in Economics
Mar 2013 to Present Office ManagerGood Samaritan Medical Center West Islip, NY Feb 2011 to Jan 2013 Certified Nursing AssistantJJI International Cranston, RI Jun 2009 to Aug 2009 Market Research and Technology Assistant
Education:
Brandeis University Waltham, MA 2006 to 2010 BA in Psychology
Oct 2013 to 2000 Property & Casualty UnderwriterBerkshire Hathaway Homestate Companies San Francisco, CA Oct 2011 to Oct 2013 Underwriting Assistant IIHertz Corporation San Francisco, CA Nov 2010 to Oct 2011 Manager AssociateMerrill Lynch and Co Santa Ana, CA Jan 2009 to Jul 2009 Wealth Management Intern
Education:
University of California Irvine, CA 2010 B.A. in Business Economics
Skills:
Proficient in using Macintosh and Windows operating systems. Knowledge of workers compensation insurance underwriting processes and procedures. Experience in using software programs such as, but not limited to: Microsoft Excel, Word, PowerPoint, Outlook, Access, Intuit QuickBooks, ProSeries, Quicken, and Citrix Access Gateway. Fluency in English, Cantonese, and Mandarin Chinese.
Empire BlueCross BlueShield Melville, NY Oct 2011 to May 2012 Underwriter Auditor - Group Integrity DepartmentMerrill Lynch & Co., Inc New York, NY Mar 2009 to Jan 2010 Tax Intern - International Compliance & Analytics GroupSt John's Episcopal Hospital Bethpage, NY Jun 2008 to Sep 2008 Accounting Intern - Finance DepartmentSocial Security Office Jamaica, NY Jun 2006 to Oct 2007 Case Technician Intern - Office of Disability Adjudication and Review
Education:
CUNY Baruch College New York, NY Jul 2012 Masters of Science in Business Computer Information Systems
2010 to Present Sr. Manager, Cross-Portfolio Services, Access Solutions Program Strategy & ManagementBLUE SHIELD OF CALIFORNIA, INC
2006 to 2010 Product Manager, Large Group Product DevelopmentBLUE SHIELD OF CALIFORNIA, INC San Francisco, CA 2004 to 2010BLUE SHIELD OF CALIFORNIA, INC
2004 to 2006 ManagerMEDEM, INC San Francisco, CA 2000 to 2003 Director, Network and Partner StrategiesHEALTHEON/WEBMD CORP San Francisco, CA 1998 to 1999 Business Process ConsultantPRICEWATERHOUSE COOPERS New York, NY 1997 to 1998 Associate, Integrated Health Care Consulting PracticeINDEPENDENCE BLUE CROSS Philadelphia, PA 1994 to 1995 Program Evaluation AnalystKAISER PERMANENTE HEALTH PLAN Oakland, CA 1991 to 1994 Medical Economics Analyst
Education:
Columbia Business School New York, NY 1997 MBA in FinanceStanford University Stanford, CA 1991 BA in Economics
spots in universities or getting scholarships, began sending their children to Australia, the U.K. and America. Thats how the exodus began, said Jason Wong, 23. Anyone could get the money together would send their children overseas to try to get a foothold there.
Date: May 17, 2018
Category: World
Source: Google
Asian Futures Foreshadow Gains as Dow Hits Record: Markets Wrap
Noteworthy is the resilience of equity markets and low volatility in the face of two horrific terrorist attacks in Europe, Jason Wong, a currency strategist at Bank of New Zealand in Wellington, wrote in a note to clients Wednesday. They seem to have had little impact on the market.
Date: Dec 20, 2016
Category: Business
Source: Google
Asian stock futures tip gains amid Italy vote; dollar holds drop
The payrolls data plays to the view, espoused by Fed Chair Yellen and others, that the Fed can afford to run the economy a little hotter than normal without being overly concerned about the potential inflation risks, said Jason Wong, a currency strategist in Wellington at Bank of New Zealand Ltd.
Date: Dec 04, 2016
Source: Google
Asian Stocks Slide With Won, Oil Amid Fed Speculation; Yen Gains
Markets have awoken to the fact that the days of further monetary stimulus may be numbered, Jason Wong, a currency strategist in Wellington at Bank of New Zealand Ltd., said in an e-mail. Markets are primed for a good old-fashioned bout of risk aversion, he said.
Date: Sep 11, 2016
Category: Business
Source: Google
Asian Futures Look Beyond U.S. Losses as Yen, Oil Nurse Declines
The dollar is stronger across the board as investors have one eye on a possible rate hike later in the year, Jason Wong, a currency strategist in Wellington at Bank of New Zealand Ltd., said in an e-mail. Friday nights U.S. employment remains a key release and it will take a positive surprise to
Date: Aug 30, 2016
Category: Business
Source: Google
Asian Stocks Climb With Won as Yen Weakens; Commodities Retreat
A June rate hike is effectively off the table, said Jason Wong, a currency strategist at Bank of New Zealand in Wellington. The market is thinking that unless we get a strong bounce-back in employment, then July is not looking likely either.
Date: Jun 06, 2016
Category: Business
Source: Google
California Brothers Arrested in Parents' Shooting Deaths
Jason Wong, 16, a classmate of the teen at Evergreen Valley High School, said the junior was "quiet and kept to himself mostly." Wong, also a junior, said he saw the teen on campus on Monday, the day after his parents were found dead.
We think that its inevitable that oil prices move back below the USD 30 market soon as supply continues to outstrip demand and inventory levels are very high, Jason Wong, a currency strategist in Wellington at Bank of New Zealand Ltd said in an e-mail to clients, according to Bloomberg.
Date: Feb 24, 2016
Category: Business
Source: Google
Youtube
Jason Wong American Pie Exhibition 2010 EWC
Jason Wong skates his American Pie exhibition program at the 2010 Jimm...
Category:
People & Blogs
Uploaded:
17 Apr, 2010
Duration:
2m 56s
Choy Li Fut - Sifu Jason Wong Gold Medal form...
2004 at the 1st World Traditional Wushu Tournament, Zhengzhou China - ...
Category:
Sports
Uploaded:
14 May, 2010
Duration:
1m 15s
Mathias Vs Jason Wong (Hong Kong) 5-3-10
5 marzo/march 2010 Mathias Gallo Cassarino (Italy) vs Jasong Wong (HK)...
Category:
Sports
Uploaded:
28 Mar, 2010
Duration:
10m 2s
Jason Wong Liberty 2010 SP partial
Category:
Sports
Uploaded:
22 Jul, 2010
Duration:
1m 19s
Jason Wong yNEEC 2010
Chinese Guy on yNEEC 2010 Check out www.six-thirteen...
New York, NYFreelance Graphic Designer / Production Assistant... Past: Graphic Designer / Web Producer at IncentOne, Graphic Designer at rix magazine Efficient Graphic Designer with five-year experience in all traditional print and web design production. Possess strong conceptual skills and ability to execute... Efficient Graphic Designer with five-year experience in all traditional print and web design production. Possess strong conceptual skills and ability to execute design concepts through a variety of mediums to produce effective and eye-catching materials and visual outcomes. Quick thinker, problem...
Project JeForceX - Executive Producer (2008) SMRT Taxis - Corporate Billing Officer (2011-2013) Singapore Armed Forces - National Serviceman (2006-2008)
Education:
Kaplan Higher Education Institute - Diploma in Commerce (Business Administration), Singapore Polytechnic - Diploma in Games Design & Development (Incomplete), Institute of Technical Education - Nitec in Multimedia Technology, Yuying Secondary School - GCE 'N' Level
About:
An adventurer who is born, raised, and resides in Singapore, a little red dot located in the south eastern corner of Asia. During his leisure time, he enjoys watching Japanese Anime, playing Games, Re...
Tagline:
Pursue your passion and live the dream!
Bragging Rights:
Owns a Canon EOS 600D
Jason Wong
Work:
State of Hawaii - Student Services Coordinator (2004)
Education:
University of Hawaii at Manoa - BEd Secondary English, University of Phoenix - MAEd in Educational Counseling, University of Phoenix - MAEd in Curriculum and Instruction
About:
Jason Aloysious Wong, MAEdCompleted HNL Marathon from 2008 - PresentAt Admr. C. W. Nimitz Elementary SchoolTraveled to: West Coast, NV, IL, IN, MA, NY, France, Australia, New Zealand, and China