Janine R Keller

US Patent:

20040105778, Jun 3, 2004

Filed:

Sep 4, 2003

Appl. No.:

10/654600

Inventors:

Robert Lee - Boyertown PA, US
Matthew Hilborn - Spring City PA, US
Laura Kline - Harleysville PA, US
Janine Keller - Collegeville PA, US

Assignee:

Elan Pharma International Limited

International Classification:

A61L009/00
B01J019/00
A62B007/08
B01J019/08
A61L002/00

US Classification:

422/022000, 422/001000, 422/004000, 422/028000, 422/040000, 422/121000, 422/123000, 422/186000, 422/292000, 422/300000, 422/305000, 422/306000

Abstract:

The present invention relates to methods for terminal sterilization of solid forms of nanoparticulate active agent compositions via gamma irradiation. The nanoparticulate active agent has an effective average particle size of less than about 2 microns, prior to incorporation into a solid form for sterilization. The resultant sterilized compositions exhibit excellent redispersibility, homogeneity, and uniformity. Also encompassed are compositions made via the described method and methods of treating animals and humans using such compositions.