Ichiro M Nakano

US Patent:

20090163406, Jun 25, 2009

Filed:

Sep 30, 2005

Appl. No.:

11/576444

Inventors:

Harley I. Kornblum - Los Angeles CA, US
Daniel H. Geschwind - Santa Monica CA, US
Ichiro Nakano - Los Angeles CA, US
Joseph D. Dougherty - New York NY, US
Jorge Lazareff - Los Angeles CA, US
Paul S. Mischel - Los Angeles CA, US
Michael D. Masterman Smith - Playa Del Rey CA, US
Jing Huan - Los Angeles CA, US
Houman D. Hemmati - Baltimore MD, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

A61K 31/70
A61K 31/7088
A61K 38/02
A61K 38/16
A61K 31/20
C40B 40/08
G01N 33/53
A61P 35/00

US Classification:

514 12, 514 44, 514 2, 514 23, 514558, 506 17, 435 721

Abstract:

In one aspect, the invention provides composition and methods for the diagnosis, prognosis and treatment of tumors and cancers, e.g., brain cancers. In one aspect, the invention provides compositions and methods for inhibiting the growth, proliferation, differentiation and/or survival of a neural stem cell or a cancer cell, or progenitor stem cell thereof. In one aspect, the invention provides compositions and methods for identifying the genetic profile of a brain cancer cell or a self-renewing neural cancer stem cell. In one aspect, the invention provides methods employing these profiles to identify compounds that inhibit tumor growth.