Hyun Chong Woo

US Patent:

8367706, Feb 5, 2013

Filed:

Jun 16, 2008

Appl. No.:

12/665045

Inventors:

Michael Altman - Cambridge MA, US
Matthew Christopher - Wallingford CT, US
Jonathan B. Grimm - Newton MA, US
Andrew Haidle - Cambridge MA, US
Kaleen Konrad - Newton MA, US
Jongwon Lim - Lexington MA, US
Rachel N. MacCoss - Brookline MA, US
Michelle Machacek - Brookline MA, US
Ekundayo Osimboni - Ashland MA, US
Ryan D. Otte - Natick MA, US
Tony Siu - Brookline MA, US
Kerrie Spencer - Woonsocket RI, US
Brandon Taoka - Allston MA, US
Paul Tempest - Brookline MA, US
Kevin Wilson - West Newton MA, US
Hyun Chong Woo - Brookline MA, US
Jonathan Young - Southborough MA, US
Anna Zabierek - Salem MA, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 31/4436
C07D 409/12

US Classification:

514336, 5462814

Abstract:

The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.

US Patent:

20110245205, Oct 6, 2011

Filed:

Dec 15, 2010

Appl. No.:

12/968608

Inventors:

Michael D. Altman - Needham MA, US
Brian M. Andresen - Sharon MA, US
Kenneth L. Arrington - Revere MA, US
Sathesh Bhat - Dollard-des-Ormeaux, CA
Jason Burch - , US
Kaleen Konrad Childers - Newton MA, US
Bernard Cote - , US
Maria Emilia Di Francesco - Brookline MA, US
Anthony Donofrio - Cambrldge MA, US
Kristina Dupont-Gaudet - Vaudreuil-Dorion, CA
John Michael Ellis - Needham MA, US
Christian Fischer - Natick MA, US
Jean-Francois Fournier - Montreal, CA
Jacques Yves Gauthier - Laval, CA
Jonathan Grimm - , US
Daniel Guay - Lachine, CA
David Joseph Guerin - Natick MA, US
Andrew M. Haidle - Cambridge MA, US
Solomon Kattar - Arlington MA, US
Sandra Lee Knowles - Boston MA, US
Chaomin Li - Boston MA, US
Jongwon Lim - Lexington MA, US
Michelle R. Machacek - Brookline MA, US
Matthew L. Maddess - Boston MA, US
Alan B. Northrup - Reading MA, US
Brendan M. O'Boyle - Boston MA, US
Ryan D. Otte - Natick MA, US
Alessia Petrocchi - Boston MA, US
Michael H. Reutershan - Brookline MA, US
Joel S. Robichaud - Dollard-des-Ormeaux, CA
Eric Romeo - Allston MA, US
Adam J. Schell - Newton MA, US
Tony Siu - Brookline MA, US
Kerrie B. Spencer - Woonsocket RI, US
Brandon M. Taoka - Brookline MA, US
B. Wesley Trotter - Newton Highlands MA, US
Hyun Chong Woo - Natick MA, US
Hua Zhou - Acton MA, US

International Classification:

A61K 31/675
C07D 417/14
A61K 31/55
C07D 417/12
A61K 31/506
C07F 9/6558
A61K 31/397
A61K 31/551
A61K 31/553
A61K 31/541
C07D 413/14
A61K 31/5377
A61P 11/06
A61P 35/00
A61P 19/02

US Classification:

514 86, 540524, 51421208, 544321, 514272, 544243, 5142102, 540492, 514218, 540544, 51421115, 544 582, 5142278, 544122, 5142358

Abstract:

The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.

US Patent:

20120277192, Nov 1, 2012

Filed:

Dec 15, 2010

Appl. No.:

13/516455

Inventors:

Michael D. Altman - Needham MA, US
Brian M. Andresen - Sharon MA, US
Kenneth L. Arrington - Revere MA, US
Sathesh Bhat - Dollard-des-Ormeaux, CA
Jason Burch - Redwood City CA, US
Kaleen Konrad Childers - Newton MA, US
Bernard Cote - Notre-Dame-de-I'Ile-Perrot, CA
Maria Emilia Di Francesco - Houston TX, US
Anthony Donofrio - Cambridge MA, US
Kristina Dupont-Gaudet - Vaudreuil-Dorion, CA
John Michael Ellis - Needham MA, US
Christian Fischer - Natick MA, US
Jean-Francois Fournier - Montreal, CA
Jacques Yves Gauthier - Laval, CA
Jonathan Grimm - Asburn VA, US
Daniel Guay - Lachine, CA
David Joseph Guerin - Natick MA, US
Andrew M. Haidle - Cambridge MA, US
Solomon Kattar - Arlington MA, US
Sandra Lee Knowles - Princeton NJ, US
Chaomin Li - Boston MA, US
Jongwon Lim - Lexintong MA, US
Michelle R. Machacek - Brookline MA, US
Matthew L. Maddess - Boston MA, US
Alan B. Northrup - Reading MA, US
Brendan M. O'Boyle - Boston MA, US
Ryan D. Otte - Natick MA, US
Alessia Petrocchi - Houston TX, US
Michael H. Reutershan - Brookline MA, US
Joel S. Robichaud - Dollar-des-Ormeaux, CA
Eric Romeo - Allston MA, US
Adam J. Schell - Decatur GA, US
Tony Siu - Brookline MA, US
Kerrie B. Spencer - Woonsocket RI, US
Brandon M. Taoka - Hoboken NJ, US
B. Wesley Trotter - Newton Highlands MA, US
Hyun Chong Woo - Natick MA, US
Hua Zhou - Acton MA, US

International Classification:

A61K 31/506
A61K 31/55
A61K 31/554
A61K 31/551
A61P 35/00
C07D 417/14
C07F 9/6539
C07D 417/12
A61P 19/02
A61P 11/06
A61K 31/675
A61K 31/5377

US Classification:

514 86, 5142102, 51421202, 51421208, 514218, 5142358, 514249, 514275, 540488, 540492, 540524, 544123, 544243, 544321

Abstract:

The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.

US Patent:

20130225577, Aug 29, 2013

Filed:

Oct 17, 2011

Appl. No.:

13/880767

Inventors:

David Joseph Guerin - Natick MA, US
Jason D. Brubaker - Cambridge MA, US
Michelle Martinez - Medford MA, US
Joon O. Jung - Newton MA, US
Neville J. Anthony - Northborough MA, US
Mark E. Scott - Andover MA, US
Carolyn Michele Cammarano - Worcestor MA, US
Dawn Marie Mampreian Hoffman - Boston MA, US
Hyun Chong Woo - Natick MA, US
Christopher J. Dinsmore - Newton MA, US
Philip Jones - Houston TX, US

International Classification:

C07D 471/04

US Classification:

5142342, 544280, 5142651, 544117

Abstract:

The instant invention provides compounds of formula I which are Jak inhibitors, and as such are useful for the treatment of Jak-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

US Patent:

20160060255, Mar 3, 2016

Filed:

Apr 22, 2014

Appl. No.:

14/786464

Inventors:

Neville J. ANTHONY - , US
Brain M. ANDERSEN - , US
Alan B. NORTHRUP - Boston MA, US
Kaleen K. CHILDERS - Boston MA, US
Anthony FRIO - Boston MA, US
Thomas A. MILLER - , US
Yuan LIU - Boston MA, US
Michelle R. MACHACEK - Boston MA, US
Hyun Chong WOO - Boston MA, US
Kerrie B. SPENCER - Boston MA, US
John Michael ELLIS - Boston MA, US
Micheal D. ALTMAN - Boston MA, US
Eric T. ROMEO - Alston MA, US
Daniel GUAY - , US
Jonathan GRIMM - , US
Marie-Eve LEBRUN - , US
Joel S. ROBICHAUD - , US
Liping WANG - , US
Byron DUBOIS - , US
Qiaolin DENG - , US
- Rabway NJ, US
- Kirkland, CA

Assignee:

Merck Canada Inc. - Kirkland QC
Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07D 417/14
A61K 31/53
A61K 31/4439
A61K 31/501
A61K 31/506
A61K 31/497

Abstract:

The invention provides certain thiazole-substituted aminoheteroaryl compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein X, X, X, X, Y, Y, Y, Y, and Rare as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).

US Patent:

20150353535, Dec 10, 2015

Filed:

Dec 19, 2013

Appl. No.:

14/653488

Inventors:

- Rahway, NJ, US
Brian M. Andresen - Sharon MA, US
Kenneth L. Arrington - Lansdale PA, US
Kaleen Konrad Childers - Medfield MA, US
Maria Emilia Di Francesco - Houston TX, US
John Michael Ellis - Needham MA, US
Andrew M. Haidle - Cambridge MA, US
Yuan Liu - Belmont MA, US
Alan B. Northrup - Reading MA, US
Brendan O'Boyle - Boston MA, US
Ryan D. Otte - Natick MA, US
Michael H. Reutershan - Brookline MA, US
Dilrukshi Vitharana - Somerville MA, US
Hyun Chong Woo - Natick MA, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07D 417/14
A61K 31/444

Abstract:

The invention provides certain thiazole-substituted aminopyridine compounds of the Formula (I) (I) or pharmaceutically acceptable salts thereof, wherein R, R, R, R, R, R, C, and the subscript t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).

US Patent:

20140349998, Nov 27, 2014

Filed:

Nov 30, 2012

Appl. No.:

14/363097

Inventors:

- Rahway NJ, US
Matthew Christopher - Brookline MA, US
Christopher Dinsmore - Newton MA, US
Joon Jung - Natick MA, US
Qinglin Pu - Melrose MA, US
Alexey Rivkin - San Francisco CA, US
Mark E. Scott - Andover MA, US
David J. Witter - Norfolk MA, US
Hyun Chong Woo - Natick MA, US
Brandon Cash - Framingham MA, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07D 487/04
C07D 471/04

US Classification:

51421109, 544280, 5142651, 540523, 51421207, 540552, 51425216, 544 582, 5142285, 544117, 5142342, 51425505, 544212, 514245

Abstract:

The instant invention provides compounds of formula I which are JAK3 inhibitors. Specifically, the compounds of formula I are pyrrolo[2,3-d]pyrimidine derivative compounds. The instant invention also provides methods of treating JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer, by administering the pyrrolo[2,3-d]pyrimidine-derivative compounds of formula I.

US Patent:

20140243290, Aug 28, 2014

Filed:

Apr 17, 2014

Appl. No.:

14/255480

Inventors:

Michael D. Altman - Needham MA, US
Brian M. Andresen - Sharon MA, US
Kenneth L. Arrington - Lansdale PA, US
Sathesh Bhat - Jersey City NJ, US
Jason Burch - Redwood City CA, US
Kaleen Konrad Childers - Medfield MA, US
Bernard Cote - Notre-Dame-de-I'll-Perrot, CA
Maria Emilia Di Francesco - Houston TX, US
Anthony Donofrio - Cambridge MA, US
Kristina Dupont-Gaudet - Vaudreuil-Dorion, CA
John Michael Ellis - Needham MA, US
Christian Fischer - Natick MA, US
Jean-Francois Fournier - Juan Les Pins, FR
Jacques Yves Gauthier - Laval, CA
Jonathan Grimm - Ashburn VA, US
Daniel Guay - Lachine, CA
David Joseph Guerin - Natick MA, US
Andrew M. Haidle - Cambridge MA, US
Solomon D. Kattar - Arlington MA, US
Sandra Lee Knowles - Princeton NJ, US
Chaomin Li - Boston MA, US
Jongwon Lim - Lexington MA, US
Michelle R. Machacek - Brookline MA, US
Matthew L. Maddess - Boston MA, US
Alan B. Northrup - Reading MA, US
Brendan M. O'Boyle - Boston MA, US
Ryan D. Otte - Natick MA, US
Alessia Petrocchi - Houston TX, US
Michael H. Reutershan - Brighton MA, US
Joel S. Robichaud - Dollard-des-Ormeaux, CA
Eric T. Romeo - Allston MA, US
Adam J. Schell - Decatur GA, US
Tony Siu - Brookline MA, US
Kerrie B. Spencer - Woonsocket RI, US
Brandon M. Taoka - Hoboken NJ, US
B. Wesley Trotter - Newton Highlands MA, US
Hyun Chong Woo - Natick MA, US
Hua Zhou - Acton MA, US

International Classification:

C07D 417/12
C07D 495/04
C07D 451/06
C07F 9/6558
C07D 471/08
C07D 487/04
C07D 471/04
C07D 417/14
C07D 491/08

US Classification:

514 86, 544331, 514275, 544230, 540524, 51421208, 544122, 5142358, 51425219, 51421018, 5142102, 540601, 51421706, 544296, 540544, 51421115

Abstract:

The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.