Jacky Y Woo

US Patent:

6861414, Mar 1, 2005

Filed:

Feb 29, 2000

Appl. No.:

09/515582

Inventors:

Roland Buelow - Palo Alto CA, US
Jacky Woo - Sunnyvale CA, US
Suhasini Iyer - San Ramon CA, US

Assignee:

Sangstat Medical Corporation - Fremont CA

International Classification:

A61K031/70
A61K048/00
A01N063/00
C12N015/74
C12N015/85
C12N005/02

US Classification:

514 44, 424 932, 424 9321, 4353201, 435325, 435455

Abstract:

Methods are provided wherein the survival of an organ transplant is enhanced by introducing into cells of the transplant a nucleic acid molecule that modulates heme oxygenase-I activity therein. Nucleic acid molecules that modulate heme oxygenase-I activity and therefore find use in the described methods include, for example, molecules that encode a polypeptide that itself exhibits heme oxygenase-I activity or antisense oligonucleotides that act to inhibit heme oxygenase-I activity in a cell.

US Patent:

7151090, Dec 19, 2006

Filed:

Feb 18, 2004

Appl. No.:

10/782260

Inventors:

Roland Buelow - Palo Alto CA, US
Jacky Woo - San Jose CA, US
Suhasini Iyer - San Ramon CA, US

Assignee:

Sangstat Medical Corporation - Fremont CA

International Classification:

A61K 31/70
A61K 48/00
A01N 63/00

US Classification:

514 44, 424 932, 424 9321, 4353201, 435325, 435455

Abstract:

Methods are provided wherein the survival of an organ transplant is enhanced by introducing into cells of the transplant a nucleic acid molecule that modulates heme oxygenase-I activity therein. Nucleic acid molecules that modulate heme oxygenase-I activity and therefore find use in the described methods include, for example, molecules that encode a polypeptide that itself exhibits heme oxygenase-I activity or antisense oligonucleotides that act to inhibit heme oxygenase-I activity in a cell.

US Patent:

20030068387, Apr 10, 2003

Filed:

Apr 1, 2002

Appl. No.:

10/115276

Inventors:

Roland Buelow - Palo Alto CA, US
Jacky Woo - San Jose CA, US

International Classification:

A61K033/00
A61K031/02

US Classification:

424/699000, 514/758000

Abstract:

Methods and compositions are provided for treating vascular disease and modulating the inflammatory and immune processes using carbon monoxide generating compounds, including methylene chloride. The subject compounds are capable of inhibiting the proliferation of vascular smooth muscle cells, protecting the vasculature against oxidative stress and injury, modulating the activity of various immune system cells, inhibiting the production of pro-inflammatory cytokines and enhancing production of anti-inflammatory cytokines, thereby being effective in the treatment of conditions associated with adverse proliferative or inflammatory responses. Methods for extending the survival of an organ transplant and inhibiting chronic rejection in a recipient are also provided.

US Patent:

20040143025, Jul 22, 2004

Filed:

Sep 13, 2003

Appl. No.:

10/661462

Inventors:

Roland Buelow - Palo Alto CA, US
Jacky Woo - San Jose CA, US
Suhasini Iyer - San Ramon CA, US

International Classification:

A61K031/02

US Classification:

514/758000

Abstract:

Methods and compositions are provided for treating vascular disease and modulating the inflammatory and immune processes using alkyl halides. The subject compounds are capable of inhibiting the proliferation of vascular smooth muscle cells, protecting the vasculature against oxidative stress and injury, modulating the activity of various immune system cells, inhibiting the production of pro-inflammatory cytokines and enhancing production of anti-inflammatory cytokines, thereby being effective in the treatment of conditions associated with adverse proliferative or inflammatory responses. Methods for extending the survival of an organ transplant and inhibiting chronic rejection in a recipient are also provided.

US Patent:

57564922, May 26, 1998

Filed:

Sep 9, 1996

Appl. No.:

8/709650

Inventors:

Roland Buelow - Palo Alto CA
Jacky Woo - Sunnyvale CA
Suhasini Iyer - San Ramon CA

Assignee:

SangStat Medical Corporation - Menlo Park CA

International Classification:

A61K 3133
A61K 31555

US Classification:

514185

Abstract:

Metalloporphyrins are administered in conjunction with transplantation to enhance the survival of the organ.

US Patent:

60604670, May 9, 2000

Filed:

Mar 20, 1998

Appl. No.:

9/045562

Inventors:

Roland Buelow - Palo Alto CA
Jacky Woo - Sunnyvale CA
Suhasini Iyer - San Ramon CA

Assignee:

SangStat Medical Corporation - Fremont CA

International Classification:

A61K 5504

US Classification:

514185

Abstract:

Metalloporphyrins are administered in conjunction with transplantation to enhance the survival of the organ.