Hsi L Liu

US Patent:

7335736, Feb 26, 2008

Filed:

Sep 6, 2005

Appl. No.:

11/221263

Inventors:

Hsi Liu - Tucker GA, US
Bret M. Steiner - Chamblee GA, US
Berta Rodes - Madrid, ES

Assignee:

The United State of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

C07K 1/00
A61K 39/00
A61K 39/02

US Classification:

530350, 4241841, 4241911, 4242621, 4242651

Abstract:

Methods for the specific and highly sensitive detection of infection comprising the use of specific antigenic proteins and peptides unique to are provided. In particular, detection assays based on recognition of acidic repeat protein are provided. The methods of the present invention are useful for detection of primary syphilis at early stages of infection. In addition, the methods and compositions disclosed herein are directed to the differential detection of specific infections enabling the identification of causative agents for specific disease states: syphilis (subspecies ), yaws (subspecies CDC-1 or CDC-2 strain), and bejel (subspecies ).

US Patent:

20050191712, Sep 1, 2005

Filed:

Dec 14, 2001

Appl. No.:

10/017168

Inventors:

Hsi Liu - Tucker GA, US
Bret Steiner - Chamblee GA, US
Berta Rodes - Madrid, ES

International Classification:

G01N033/53
G01N033/569
A61K039/002
C07K016/20

US Classification:

435007220, 424191100, 530388600

Abstract:

Methods for the specific and highly sensitive detection of infection comprising the use of specific antigenic proteins and peptides unique to are provided. In particular, detection assays based recognition of acidic repeat protein are provided. The methods of the present invention are useful for detection of primary syphilis at early stages of infection. In addition, the methods and compositions disclosed herein are directed to the differential detection of specific infections enabling the identification of causative agents for specific disease states: syphilis (subspecies ), yaws (subspecies CDC-1 or CDC-2 strain), and bejel (subspecies ).

US Patent:

20080139783, Jun 12, 2008

Filed:

Dec 26, 2007

Appl. No.:

11/964552

Inventors:

Hsi Liu - Tucker GA, US
Bret M. Steiner - Chamblee GA, US
Berta Rodes - Madrid, ES

International Classification:

C07K 16/00

US Classification:

530300, 530350

Abstract:

Methods for the specific and highly sensitive detection of infection comprising the use of specific antigenic proteins and peptides unique to are provided. In particular, detection assays based on recognition of acidic repeat protein are provided. The methods of the present invention are useful for detection of primary syphilis at early stages of infection. In addition, the methods and compositions disclosed herein are directed to the differential detection of specific infections enabling the identification of causative agents for specific disease states: syphilis (subspecies ), yaws (subspecies CDC-1 or CDC-2 strain), and bejel (subspecies ).