Hirokazu Tsukamoto

US Patent:

8604004, Dec 10, 2013

Filed:

Oct 3, 2008

Appl. No.:

12/681052

Inventors:

Daniel Kahne - Brookline MA, US
Suzanne Walker Kahne - Brookline MA, US
Masaatsu Adachi - Nagoya, JP
Emma Doud - Cambridge MA, US
Shinichiro Fuse - Gumma, JP
Xiaonan Lin - Mendota Heights MN, US
Yi Zhang - San Diego CA, US
Hirokazu Tsukamoto - Cambridge MA, US
Bohdan Ostash - L'viv, UA

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

A61K 31/702
A61K 31/715
A61K 31/7016
A61K 31/7028
C07H 5/04
C07H 5/06

US Classification:

514 61, 514 54, 514 25, 536 551, 536 53, 536 41

Abstract:

The present invention provides novel moenomycin analogs as well as pharmaceutical compositions thereof, methods of synthesis, and methods of use in treating an infection by administering an inventive compound to a subject in need thereof. The moenomycin analogs may be prepared synthetically, biosynthetically, or semi-synthetically. The analogs are particularly useful in treating or preventing infections caused by Gram-positive organisms. Certain inventive compounds may have a broader spectrum of coverage, which includes Gram-negative organisms.