Heejin Kim

US Patent:

7022679, Apr 4, 2006

Filed:

Jan 14, 2004

Appl. No.:

10/758409

Inventors:

Heejin Kim - Allston MA, US
Guoqiang Wang - Belmont MA, US
Yat Sun Or - Watertown MA, US
Zhe Wang - Hockessin DE, US

Assignee:

Enanta Pharmaceuticals, Inc. - Watertown MA

International Classification:

C07H 17/08

US Classification:

514 29, 536 74, 536 185

Abstract:

The present invention relates to processes and intermediates for the preparation of 6–11 bicyclic erythromycin derivatives. In particular, the present invention relates to processes and intermediates for the preparation of a compound of formula (IX-c):.

US Patent:

7064110, Jun 20, 2006

Filed:

Nov 19, 2003

Appl. No.:

10/717290

Inventors:

Yat Sun Or - Watertown MA, US
Wang Guoqiang - Belmont MA, US
Ly Tam Phan - Quincy MA, US
Deqiang Niu - Lexington MA, US
Nha Huu Vo - Southborough MA, US
Yao-Ling Qiu - Andover MA, US
Yanchun Wang - Somerville MA, US
Marina Busuyek - Natick MA, US
Ying Hou - Everett MA, US
Yulin Peng - Belmont MA, US
Heejin Kim - Allston MA, US
Tongzhu Liu - Auburndale MA, US
Jay Judson Farmer - New Haven CT, US
Guoyou Xu - Auburndale MA, US

Assignee:

Enanta Pharmaceuticals, Inc. - Watertown MA

International Classification:

A61K 31/70
C07H 17/08

US Classification:

514 29, 536 74

Abstract:

The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof:.

US Patent:

7135573, Nov 14, 2006

Filed:

Oct 25, 2005

Appl. No.:

11/257680

Inventors:

Heejin Kim - Allston MA, US
Guoqiang Wang - Belmont MA, US
Yat Sun Or - Watertown MA, US
Zhe Wang - Hockessin DE, US
Guoyou Xu - Newton MA, US
Ly Tam Pham - Quincy MA, US

Assignee:

Enanta Pharmaceuticals, Inc. - Watertown MA

International Classification:

C07D 237/02
A61K 31/7052

US Classification:

5462754, 514 29

Abstract:

The present invention relates to processes and intermediates for the preparation of 6–11 bicyclic erythromycin derivatives. In particular, the present invention relates to processes and intermediates for the preparation of a compound of formula (IX-c):.

US Patent:

7273853, Sep 25, 2007

Filed:

Jan 25, 2005

Appl. No.:

11/042720

Inventors:

Yat Sun Or - Watertown MA, US
Guoqiang Wang - Belmont MA, US
Ly Tam Phan - Quincy MA, US
Deqiang Niu - Lexington MA, US
Nha Huu Vo - Southborough MA, US
Yao-Ling Qiu - Andover MA, US
Yanchun Wang - Somerville MA, US
Marina Busuyek - Natick MA, US
Ying Hou - Everett MA, US
Yulin Peng - Belmont MA, US
Heejin Kim - Allston MA, US
Tongzhu Liu - Auburndale MA, US
Jay Judson Farmer - New Haven CT, US
Guoyou Xu - Auburndale MA, US

Assignee:

Enanta Pharmaceuticals, Inc. - Watertown MA

International Classification:

A61K 31/70
C07H 17/08

US Classification:

514 29, 536 72, 536 74

Abstract:

The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof:.

US Patent:

7538225, May 26, 2009

Filed:

Aug 17, 2005

Appl. No.:

11/205764

Inventors:

Datong Tang - Watertown MA, US
Yao-Ling Qiu - Andover MA, US
Heejin Kim - Allston MA, US
Yat Sun Or - Watertown MA, US
Zhe Wang - Hockessin DE, US

Assignee:

Enanta Pharmaceuticals, Inc. - Watertown MA

International Classification:

C07D 401/04

US Classification:

5462754

Abstract:

The present invention relates generally to novel methods for the synthesis of O-(6-pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine which is an essential reagent in the synthesis of one of the bridged erythromycin derivatives and their respective pharmaceutically acceptable salts in PCT Application WO 03/097659 A1. In particular, the present invention relates to processes and intermediates for the preparation of a compound of formula (Ia):.

US Patent:

7919627, Apr 5, 2011

Filed:

Jun 9, 2008

Appl. No.:

12/135299

Inventors:

Datong Tang - Watertown MA, US
Yao-Ling Qiu - Andover MA, US
Heejin Kim - Allston MA, US
Yat Sun Or - Watertown MA, US
Zhe Wang - Hockessin DE, US

Assignee:

Enanta Pharmaceuticals, Inc. - Watertown MA

International Classification:

C07D 401/04

US Classification:

5462754

Abstract:

The present invention relates generally to novel methods for the synthesis of O-(6-pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine which is an essential reagent in the synthesis of one of the bridged erythromycin derivatives and their respective pharmaceutically acceptable salts in PCT Application WO 03/097659 A1. In particular, the present invention relates to processes and intermediates for the preparation of a compound of formula (Ia):.

US Patent:

8273720, Sep 25, 2012

Filed:

Feb 18, 2009

Appl. No.:

12/388333

Inventors:

In Jong Kim - Lexington MA, US
Tongzhu Liu - Auburndale MA, US
Heejin Kim - Allston MA, US
Yanchun Wang - Newton MA, US
Yao-Ling Qiu - Andover MA, US
Ly Tam Phan - Quincy MA, US
Yat Sun Or - Watertown MA, US

Assignee:

Enanta Pharmaceuticals, Inc. - Watertown MA

International Classification:

A61K 31/70
C07H 17/08

US Classification:

514 29, 536 73, 536 74

Abstract:

The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof:.

US Patent:

8354383, Jan 15, 2013

Filed:

Mar 6, 2009

Appl. No.:

12/399801

Inventors:

In Jong Kim - Lexington MA, US
Tongzhu Liu - Auberdale MA, US
Jiang Long - Wayland MA, US
Guoqiang Wang - Belmont MA, US
Yao-Ling Qiu - Andover MA, US
Heejin Kim - Belmont MA, US
Yanchun Wang - Newton MA, US
Ly Tam Phan - Quincy MA, US
Yat Sun Or - Watertown MA, US

Assignee:

Enanta Pharmaceuticals, Inc. - Watertown MA

International Classification:

A61K 31/70
C07H 17/08

US Classification:

514 29, 536 74

Abstract:

The present invention discloses compounds of formula I, II or X, or pharmaceutically acceptable salts, esters, or prodrugs thereof:.