Haris Adnana Vikalo

Author:

Haris Vikalo

ISBN #:

0521870992

US Patent:

20070099198, May 3, 2007

Filed:

Mar 14, 2006

Appl. No.:

11/376398

Inventors:

Babak Hassibi - San Marino CA, US
Haris Vikalo - Pasadena CA, US
Arjang Hassibi - Palo Alto CA, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

C12Q 1/68
G06F 19/00

US Classification:

435006000, 702020000

Abstract:

The disclosure provides methods, device, and systems for analyzing biological array data. In particular, the disclosure provide methods and computer implemented techniques for reducing interference in microarray data, and exploiting it to obtain more accurate readouts

US Patent:

20080039339, Feb 14, 2008

Filed:

Jun 5, 2007

Appl. No.:

11/758621

Inventors:

Arjang Hassibi - Austin TX, US
Babak Hassibi - San Marino CA, US
Haris Vikalo - Pasadena CA, US
Jose Riechmann - Pasadena CA, US

International Classification:

C40B 30/04
C40B 60/12
G06G 7/48

US Classification:

506009000, 506039000, 703011000

Abstract:

This invention provides methods and systems for measuring the binding of analytes in solution to probes bound to surfaces in real-time.

US Patent:

20080176757, Jul 24, 2008

Filed:

Jul 27, 2007

Appl. No.:

11/829861

Inventors:

Arjang Hassibi - Austin TX, US
Babak Hassibi - San Marino CA, US
Haris Vikalo - Pasadena CA, US

International Classification:

C40B 30/04
C40B 30/00
C12M 1/00
C12Q 1/68

US Classification:

506 9, 506 7, 4352872, 435 6

Abstract:

This invention provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (PCR) in the presence of an array of nucleic acid probes. The amount of amplicon corresponding to the multiple nucleic acid sequences can be measured in real-time during or after each cycle using a real-time microarray. The measured amount of amplicon produced can be used to determine the original amount of the nucleic acid sequences in the sample.

US Patent:

20120077692, Mar 29, 2012

Filed:

Sep 22, 2011

Appl. No.:

13/240603

Inventors:

Arjang Hassibi - Austin TX, US
Babak Hassibi - San Marino CA, US
Haris Vikalo - Pasadena CA, US

Assignee:

CALIFORNIA INSTITUTE OF TECHNOLOGY - Pasadena CA

International Classification:

C40B 30/04
C40B 40/06

US Classification:

506 9, 506 16

Abstract:

This invention provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (PCR) in the presence of an array of nucleic acid probes. The amount of amplicon corresponding to the multiple nucleic acid sequences can be measured in real-time during or after each cycle using a real-time microarray. The measured amount of amplicon produced can be used to determine the original amount of the nucleic acid sequences in the sample.

US Patent:

20220195506, Jun 23, 2022

Filed:

Jul 22, 2021

Appl. No.:

17/383277

Inventors:

- Pasadena CA, US
Babak Hassibi - San Marino CA, US
Haris Vikalo - Pasadena CA, US
Jose Luis Riechmann - Pasadena CA, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

C12Q 1/6837
C40B 30/04
G01N 33/543
G01N 21/64

Abstract:

This present disclosure provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (PCR) in the presence of an array of nucleic acid probes. The amount of amplicon corresponding to the multiple nucleic acid sequences can be measured in real-time during or after each cycle using a real-time microarray. The measured amount of amplicon produced can be used to determine the original amount of the nucleic acid sequences in the sample. Also provided herein are biosensor arrays, systems and methods for affinity based assays that are able to simultaneously obtain high quality measurements of the binding characteristics of multiple analytes, and that are able to determine the amounts of those analytes in solution. The present disclosure also provides a fully integrated bioarray for detecting real-time characteristics of affinity based assays.

US Patent:

20230016567, Jan 19, 2023

Filed:

Sep 19, 2022

Appl. No.:

17/933442

Inventors:

- Pasadena CA, US
Babak Hassibi - San Marino CA, US
Haris Vikalo - Pasadena CA, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

C12Q 1/6851
C12Q 1/686

Abstract:

This invention provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (PCR) in the presence of an array of nucleic acid probes. The amount of amplicon corresponding to the multiple nucleic acid sequences can be measured in real-time during or after each cycle using a real-time microarray. The measured amount of amplicon produced can be used to determine the original amount of the nucleic acid sequences in the sample.

US Patent:

20190323070, Oct 24, 2019

Filed:

Apr 10, 2019

Appl. No.:

16/380584

Inventors:

- Pasadena CA, US
Babak HASSIBI - San Marino CA, US
Haris VIKALO - Pasadena CA, US
Jose Luis RIECHMANN - Pasadena CA, US

International Classification:

C12Q 1/6837
C40B 30/04
G01N 33/543
G01N 21/64

Abstract:

This present disclosure provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (PCR) in the presence of an array of nucleic acid probes. The amount of amplicon corresponding to the multiple nucleic acid sequences can be measured in real-time during or after each cycle using a real-time microarray. The measured amount of amplicon produced can be used to determine the original amount of the nucleic acid sequences in the sample. Also provided herein are biosensor arrays, systems and methods for affinity based assays that are able to simultaneously obtain high quality measurements of the binding characteristics of multiple analytes, and that are able to determine the amounts of those analytes in solution. The present disclosure also provides a fully integrated bioarray for detecting real-time characteristics of affinity based assays.

US Patent:

20180251828, Sep 6, 2018

Filed:

May 7, 2018

Appl. No.:

15/972514

Inventors:

- Pasadena CA, US
Babak Hassibi - San Marino CA, US
Haris Vikalo - Pasadena CA, US

International Classification:

C12Q 1/6851
G01N 21/64
C12Q 1/686

Abstract:

This invention provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (PCR) in the presence of an array of nucleic acid probes. The amount of amplicon corresponding to the multiple nucleic acid sequences can be measured in real-time during or after each cycle using a real-time microarray. The measured amount of amplicon produced can be used to determine the original amount of the nucleic acid sequences in the sample. Also provided herein are biosensor arrays, systems and methods for affinity based assays that are able to simultaneously obtain high quality measurements of the binding characteristics of multiple analytes, and that are able to determine the amounts of those analytes in solution. The invention also provides a fully integrated bioarray for detecting real-time characteristics of affinity based assays.