George P Claxton

age ~95

from Cincinnati, OH

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Also known as:

Phone and address:: 463 Woodlands Ridge Dr, Cincinnati, OH 45238
513 451-7676

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George Claxton Phones & Addresses

2-Hydro Xy-5-[1-Hydroxy-2-[4-(2-Oxo-1-Benzimidazolinyl)Piperidino]Ethyl]Benzoic Acid Derivatives
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US Patent:

42007550, Apr 29, 1980
Filed:

May 4, 1979
Appl. No.:

6/036245
Inventors:

J. Martin Grisar - Cincinnati OH
George P. Claxton - Cincinnati OH
Assignee:

Richardson-Merrell Inc. - Wilton CT
International Classification:

C07D40104
US Classification:

546199
Abstract:

Derivatives of 2-hydroxy-5-[1-hydroxy-2-[4-(2-oxo-1-benzimidazolinyl)piperidino]ethyl]ben zoic acid are prepared which are useful for their blocking action on. alpha. and. beta. -adrenergic receptors. In addition, these compounds are useful for their spasmolytic and anti-hypertensive activity.

Cardiotonic Phenyl Oxazolones
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US Patent:

47286610, Mar 1, 1988
Filed:

Nov 13, 1985
Appl. No.:

6/797578
Inventors:

Richard A. Schnettler - Cincinnati OH
Winton D. Jones - Cincinnati OH
George P. Claxton - Cincinnati OH
Assignee:

Merrell Dow Pharmaceuticals Inc. - Cincinnati OH
International Classification:

A61K 3142
US Classification:

514376
Abstract:

Phenyloxazolones are useful as cardiotonics in the treatment of heart failure and enhance cardiac function.

N-(Phenylether-Substituted Benzyl)Alkanediamines
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US Patent:

40384128, Jul 26, 1977
Filed:

Aug 25, 1975
Appl. No.:

5/607333
Inventors:

J. Martin Grisar - Cincinnati OH
George P. Claxton - Cincinnati OH
Assignee:

Richardson-Merrell Inc. - Wilton CT
International Classification:

A01N 920
C07C 8728
US Classification:

424280
Abstract:

Novel N-(substituted benzyl)alkanediamines are prepared which are useful for the prevention and inhibition of viral infections.

.Alpha.-Alkylbenzyl Lactamimides
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US Patent:

40555615, Oct 25, 1977
Filed:

Apr 25, 1973
Appl. No.:

5/354443
Inventors:

J. Martin Grisar - Cincinnati OH
George P. Claxton - Cincinnati OH
Robert D. MacKenzie - Cincinnati OH
Assignee:

Richardson-Merrell Inc. - Wilton CT
International Classification:

C07D22312
A61K 3155
C07D20722
C07D21172
US Classification:

260239B
Abstract:

Novel derivatives of. alpha. -alkylbenzyl lactamimide are useful as anticoagulants.

Cardiotonic Heterocyclic Oxazolones
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US Patent:

46983538, Oct 6, 1987
Filed:

Nov 13, 1985
Appl. No.:

6/797580
Inventors:

Richard A. Schnettler - Cincinnati OH
Winton D. Jones - Cincinnati OH
George P. Claxton - Cincinnati OH
Assignee:

Merrell Dow Pharmaceuticals Inc. - Cincinnati OH
International Classification:

C07D40100
C07D41900
C07D41300
C07D26304
US Classification:

514340
Abstract:

Heterocyclic oxazolones enhance myocardial contractile force and cardiac function and are used as cardiotonics in the treatment of heart failure.

Cardiotonic Phenyl Oxazolones
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US Patent:

48660850, Sep 12, 1989
Filed:

Nov 24, 1987
Appl. No.:

7/124806
Inventors:

Richard A. Schnettler - Cincinnati OH
George P. Claxton - Cincinnati OH
Winton D. Jones - Cincinnati OH
Assignee:

Merrell Dow Pharmaceuticals Inc. - Cincinnati OH
International Classification:

A61K 3142
US Classification:

514376
Abstract:

Phenyloxazolones are useful as cardiotonics in the treatment of heart failure and enhance cardiac function.

Process For Preparing Quinoline Aldehyde And Ketone Derivatives
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US Patent:

49994310, Mar 12, 1991
Filed:

Feb 23, 1990
Appl. No.:

7/483831
Inventors:

Winton D. Jones - Cincinnati OH
Richard C. Dage - Cincinnati OH
George P. Claxton - Cincinnati OH
Hsien C. Cheng - Cincinnati OH
Phillip J. Robinson - Fitzroy, AU
Assignee:

Merrell Dow Pharmaceuticals - Cincinnati OH
International Classification:

C07D21514
US Classification:

546168
Abstract:

This invention relates to novel quinolyloxazole-2-ones which are useful as protein kinase C inhibitors, effective in the treatment of hypertension and asthma. This invention also includes a novel procedure for producing an intermediate ketone compound involving the reaction of a bromo-quinoline compound with butyl lithium and further reacting the lithiated compound with N-methyl-N-methoxyalkanamide.

Method Of Using Quinolyloxazole-2-Ones As Proteinkinase C Inhibitors
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US Patent:

49905198, Feb 5, 1991
Filed:

Feb 23, 1990
Appl. No.:

7/484581
Inventors:

Winton D. Jones - Cincinnati OH
George P. Claxton - Cincinnati OH
Richard C. Dage - Cincinnati OH
Hsien C. Cheng - Cincinnati OH
Phillip J. Robinson - Fitzroy, AU
Assignee:

Merrell Dow Pharmaceuticals - Cincinnati OH
International Classification:

A61K 3142
US Classification:

514314
Abstract:

This invention relates to novel quinolyloxazole-2-ones which are useful as protein kinase C inhibitors, effective in the treatment of hypertension and asthma. This invention also includes a novel procedure for producing an intermediate ketone compound involving the reaction of a bromo-quinoline compound with butyl lithium and further reacting the lithiated compound with N-methyl-N-methoxyalkanamide.