Daniel M Carson

Author:

Daniel D. Carson

ISBN #:

0387988068

US Patent:

7671018, Mar 2, 2010

Filed:

Aug 27, 2001

Appl. No.:

10/363368

Inventors:

Daniel D. Carson - Hockessin DE, US
Mary C. Farach-Carson - Hockessin DE, US
Margaret French - Houston TX, US
Ronald Gomes - San Jose CA, US
Rupert Timpl - Ga{hacek over (u)}ting, AT

Assignee:

University of Delaware - Newark DE

International Classification:

A61K 38/17
A61K 38/18
A61L 27/40
C07K 14/47
C07K 14/475

US Classification:

514 12, 530350, 530395, 424422

Abstract:

New uses of proteoglycans to bind and present growth factors, methods of accelerating wound, tissue or bone repair using such proteoglycans, pharmaceutical compositions of such proteoglycans, and scaffolds coated with such proteoglycans are disclosed. The proteoglycan of the invention is derived from domain I or perlecan.

US Patent:

7803905, Sep 28, 2010

Filed:

Aug 27, 2001

Appl. No.:

10/363376

Inventors:

Mary C. Farach-Carson - Hockessin DE, US
Daniel D. Carson - Hockessin DE, US
Jeffrey B. Safran - Newark DE, US

Assignee:

University of Delaware - Newark DE

International Classification:

C07K 14/00

US Classification:

530350, 530300, 435 71

Abstract:

The invention is directed to a polypeptide derived from domain IV of the extracellular matrix protein perlecan that can selectively adhere cells, nucleic acids encoding the inventive polypeptide, vectors comprising the nucleic acids, devices comprising a scaffold coated with the inventive polypeptide, and methods of adhering cells to a scaffold using the inventive polypeptide.

US Patent:

7897727, Mar 1, 2011

Filed:

Mar 5, 2009

Appl. No.:

12/398534

Inventors:

Mary C. Farach-Carson - Hockessin DE, US
Daniel D. Carson - Hockessin DE, US
Jeffrey B. Safran - Bear DE, US

Assignee:

University of Delaware - Newark DE

International Classification:

C07K 14/00

US Classification:

530350, 530300, 435 71

Abstract:

Implantable devices for adhering eukaryotic cells and devices providing a substrate for eukaryotic cell growth and/or differentiation in vitro are described. Each device comprises a scaffold that is coated with a protein comprising an adhesive polypeptide that has at least 90% sequence identity to a specific peptide sequence within domain IV of perlecan. The devices adhere epithelial cells, epithelial stem cells, mesenchymal stem cells, and osteoblasts.

US Patent:

20090162436, Jun 25, 2009

Filed:

Jun 7, 2007

Appl. No.:

11/811378

Inventors:

Daniel D. Carson - Hockessin DE, US
Mary C. Farach-Carson - Hockessin DE, US
Weidong (William) Yang - Newark DE, US

International Classification:

A61K 47/48
A61K 9/00
A61P 19/00

US Classification:

424484, 514 12

Abstract:

Biomaterials providing sustained release of growth factor for repair of tissues such as bone and cartilage are disclosed. The biomaterials comprise a proteoglycan derived from domain I of perlecan and a growth factor, and, optionally, collagen.