Charlton J Chen

US Patent:

20100270481, Oct 28, 2010

Filed:

Jun 16, 2008

Appl. No.:

12/664627

Inventors:

Chee Wei Wong - New York NY, US
Xiaodong Yang - New York NY, US
Charlton Chen - New York NY, US
Chad Husko - New York NY, US

Assignee:

Columbia University - New York NY

International Classification:

G21K 5/02
G02B 6/10
B05D 5/06

US Classification:

2505031, 385131, 427162, 977890, 977880, 977834, 977774, 977902

Abstract:

Some embodiments of the disclosed subject matter provide systems, devices, and methods for tuning resonant wavelengths of an optical resonator. Some embodiments of the disclosed subject matter provide systems, devices, and methods for tuning dispersion properties of photonic crystal waveguides. In some embodiments, methods for tuning a resonant wavelength of an optical resonator are provided, the methods including: providing an optical resonator having a surface; determining an initial resonant wavelength emitted by the optical resonator in response to an electromagnetic radiation input; determining a number of layers of dielectric material based on a difference between the initial resonant wavelength and a target resonant wavelength and a predetermined tuning characteristic; and applying the determined number of layers of dielectric material to the surface of the optical resonator to tune the initial resonant wavelength to a tuned resonant wavelength.

US Patent:

20200303803, Sep 24, 2020

Filed:

Jun 8, 2020

Appl. No.:

16/896096

Inventors:

- Ann Arbor MI, US
Charlton Chen - Northville MI, US
Michael M. Thornton - London, CA

Assignee:

ENDRA Life Sciences Inc. - Ann Arbor MI

International Classification:

H01P 11/00
H01P 3/12

Abstract:

A method for manufacturing a radio frequency (RF) applicator which includes covering a ceramic insert with a coating, wherein the ceramic insert has dimensions that substantially match an internal volume of an open-ended, hollow waveguide, and wherein the ceramic insert has a recess therein configured to accept a radio frequency emitter, heating the waveguide to a temperature that is above a melting point of the coating, placing the coated ceramic insert into the internal volume of the heated waveguide, wherein the internal volume is completely filled except for the recess, and cooling the waveguide, ceramic insert, and coating to a temperature below the melting point of the coating so that the coating solidifies and fills gaps between facing surfaces of the insert and the waveguide.

US Patent:

20200205669, Jul 2, 2020

Filed:

Dec 28, 2018

Appl. No.:

16/235039

Inventors:

- Ann Arbor MI, US
Charlton Chen - Northville MI, US
Michael M. Thornton - London, CA

Assignee:

ENDRA Life Sciences Inc. - Ann Arbor MI

International Classification:

A61B 5/00
A61B 8/00
G01N 29/24

Abstract:

A radio frequency applicator comprises an open-ended, hollow waveguide having an aperture therein. A solid insert is positioned within the waveguide. The solid insert has a recess formed therein that is aligned with the aperture. Filler material is provided between facing surfaces of the waveguide and the insert to fill gaps therebetween. A radio frequency (RF) source extends through the aperture and into the recess and is configured to generate RF energy pulses.

US Patent:

20200054771, Feb 20, 2020

Filed:

Aug 17, 2018

Appl. No.:

16/104472

Inventors:

- Ann Arbor MI, US
Charlton Chen - Ann Arbor MI, US
Paul A. Picot - London, CA
Marco A. Mena - Santa Clara CA, US

Assignee:

ENDRA Life Sciences Inc. - Ann Arbor MI

International Classification:

A61K 49/22

Abstract:

A thermoacoustic imaging method comprises administering a thermoacoustic imaging contrast agent to a subject, the thermoacoustic imaging contrast agent having a viscosity higher than blood and substantially similar to a viscosity of a known computed tomography (CT) or magnetic resonance imaging (MRI) contrast agent; and imaging the subject with a thermoacoustic imaging system. The thermoacoustic imaging contrast agent may comprise an ionic solution and thickening agent mixture, with an optional heating agent. The ionic salt makes 0.5% to 5.0% of the ionic solution by weight and the remainder of the ionic solution is water. The thickening agent makes 3% to 50% of the mixture by weight.