Charles J Keller

Author:

Charles L. Keller

ISBN #:

0874806771

Author:

Charles Keller

ISBN #:

0138797439

Author:

Charles Keller

ISBN #:

0139250573

Author:

Charles Keller

ISBN #:

0139441824

Author:

Charles Keller

ISBN #:

0139549676

Author:

Charles Keller

ISBN #:

0139616152

Author:

Charles Keller

ISBN #:

0130214108

Author:

Charles Keller

ISBN #:

0130499099

US Patent:

8189737, May 29, 2012

Filed:

Jan 26, 2007

Appl. No.:

12/162376

Inventors:

Charles Keller - San Antonio TX, US
Ali N. Bahadur - San Antonio TX, US

Assignee:

The Board of Regents, The University of Texas System, a Texas Institution of Higher Learning - San Antonio TX

International Classification:

G01N 23/00
G06K 9/00

US Classification:

378 18, 382131

Abstract:

Processes for producing a microCT image for virtual histology using x-ray microscopic computed tomography are described along with processes for rapid and inexpensive high-throughput methods of high resolution imaging for screening an ex vivo embryo for phenotype using computed tomography imaging. Staining of particular components of specimens with one or more staining agents is described which contributes to high quality image generation and identification of anatomical structures as well as localization of molecular targets. Inventive animal and specimen holders are detailed which allow for reduced post-imaging processing of generated images. In particular, animal and specimen holders are provided which include a highly transparent bed or liner which separates the animal or specimen from a less transparent structure. A further animal holder is provided for placing and/or maintaining the animal in a desired position during an imaging procedure or multiple imaging procedures including a bed conforming to the animal's body.

US Patent:

20080031816, Feb 7, 2008

Filed:

Aug 3, 2007

Appl. No.:

11/888995

Inventors:

Charles Keller - San Antonio TX, US

International Classification:

A61K 49/00
A01K 67/00
A61P 43/00
C12Q 1/68
G01N 31/00
G01N 33/00
G01N 33/48
G01N 33/92

US Classification:

424009100, 435006000, 435007100, 436104000, 436063000, 436071000, 436086000, 800003000

Abstract:

The present invention provides methods and compositions for the identification and validation of biomarkers. The methods and compositions of the invention include the use of exogenous molecules specifically designed and chosen to be associated with a particular disease or biological process. Biomarkers identified and used according to the invention can be indicative of a number of biological processes, including disease state, response to a therapeutic intervention (such as pharmacological treatment, radiation therapy, chemotherapy, combination therapies, and the like), and responses to physiological challenges (such as aging, environmental toxins, etc.). Biomarkers identified through the methods and compositions of the invention may also serve as targets of therapeutic interventions.

US Patent:

20080240527, Oct 2, 2008

Filed:

Aug 15, 2007

Appl. No.:

11/839414

Inventors:

Charles Keller - San Antonio TX, US

International Classification:

G06K 9/00

US Classification:

382128

Abstract:

The present invention provides methods, compositions and systems for the analysis of imaging data, in particular, whole-animal imaging data acquired using microCT. Included in the invention are methods for registering and comparing test images to one or more reference images to identify and analyze anatomical features of interest. Also provided by the invention are methods and systems for efficient, semi-automatic and fully automatic methods for generating morphological statistics for anatomical features contained in imaging data. Libraries of images, including raw data acquired from imaging apparatuses as well as processed images, are also encompassed by the present invention.

US Patent:

20080260646, Oct 23, 2008

Filed:

Sep 16, 2005

Appl. No.:

11/575057

Inventors:

Charles Keller - San Antonio TX, US
Patrick J. Hawkes - Bountiful UT, US

International Classification:

A61K 49/00
A01K 67/027
C12N 15/87
C12N 5/06
G01N 33/569
A61P 43/00

US Classification:

424 93, 424 91, 424 96, 800 25, 435455, 435325, 800 9, 435 721

Abstract:

Disclosed are compositions and methods for imaging in animals.

US Patent:

50735071, Dec 17, 1991

Filed:

Mar 4, 1991

Appl. No.:

7/664142

Inventors:

Charles T. Keller - Tempe AZ
Schyi-Yi Wu - Mesa AZ

Assignee:

Motorola, Inc. - Schaumburg IL

International Classification:

H01L 2100
H01L 2102
H01L 21306

US Classification:

437 22

Abstract:

A plasma containing both beryllium ions and beryllium fluoride ions is achieved. Beryllium crystals are used as a cathode in an ionization chamber containing boron trifluoride gas. The boron trifluoride gas and the beryllium are ionized to produce both beryllium fluoride ions (BeF. sup. +) and beryllium ions (Be. sup. +). Beryllium fluoride ions are emitted to impact a semiconductor target and where they divide thereby implanting beryllium and fluorine.