Charles Fred Keller

US Patent:

7083923, Aug 1, 2006

Filed:

Jul 20, 2001

Appl. No.:

10/296012

Inventors:

Charles Keller - Salt Lake City UT, US
Linda Ballard - Salt Lake City UT, US
Richard Lemmons - Salt Lake City UT, US
Francis Ali-Osman - Houston TX, US

Assignee:

University of Utah Research Foundation - Salt Lake City UT

International Classification:

C12Q 1/68
C12P 19/34
C07H 21/04

US Classification:

435 6, 435 912, 536 235, 536 2431, 536 2433

Abstract:

A high-throughput assay for characterizing a subject's genetic makeup is disclosed. Specifically a high-throughput assay utilizing PCR is disclosed that permits the rapid and accurate characterization of a subject's inherited alleles of the polymorphic glutathione S-transferase (GST) genes GSTM1, GSTM3, GSTP1, and GSTT1. This method allows detection of the specific alleles inherited, including the gene dosage of GSTM1 and GSTT1 while not requiring restriction endonuclease digestion of the PCR products in order to detect length differences. Further, the method allows all analyses to be performed simultaneously in the same gel lane, thus further adding efficiency and cost-effectiveness.

US Patent:

20060194200, Aug 31, 2006

Filed:

Oct 15, 2003

Appl. No.:

10/530512

Inventors:

Charles Keller - SALT LAKE CITY UT, US
Linda Ballard - Salt Lake City UT, US
Richard Lemmons - Salt Lake City UT, US
Francis Ali-Osman - Houston TX, US

International Classification:

C12Q 1/68
C12P 19/34

US Classification:

435006000, 435091200

Abstract:

A high-throughput assay for characterizing a subject's genetic makeup is disclosed. Specifically, a high-throughput assay utilizing PCR is disclosed that permits the rapid and accurate characterization of a subject's inherited alleles of the polymorphic glutathione S-transferase (GST) genes GSTM, GSTM, GSTP, and GSTT. This method allows detection of the specific alleles inherited, including the gene dosage of GSTMand GSTTwhile not requiring restriction endonuclease digestion of the PCR products in order to detect length differences. Further, the method allows all analyses to be performed simultaneously in the same gel lane, thus further adding efficiency and cost-effectiveness.

US Patent:

20130023436, Jan 24, 2013

Filed:

Jan 11, 2011

Appl. No.:

13/521853

Inventors:

Bryan William Jones - Salt Lake City UT, US
Greg Jones - Salt Lake City UT, US
Charles Keller - Portland OR, US
Marguerite Shaw - Salt Lake City UT, US
James Anderson - Corvallis OR, US
Robert E. Marc - Salt Lake City UT, US

International Classification:

C40B 30/04

US Classification:

506 9

Abstract:

Disclosed are methods for detecting the presence or absence of disease in subjects based, at least in part, on results of analysis of a sample using computational molecular phenotyping. Further disclosed herein are methods for monitoring the status of subjects diagnosed with disease based at least partially on results of computational molecular phenotyping. The test samples disclosed herein are represented by, but not limited in anyway to, biopsy samples of body tissue.

Author:

Charles L. Keller

ISBN #:

0874806771

Author:

Charles Keller

ISBN #:

0138797439

Author:

Charles Keller

ISBN #:

0139250573

Author:

Charles Keller

ISBN #:

0139441824

Author:

Charles Keller

ISBN #:

0139549676

Author:

Charles Keller

ISBN #:

0139616152

Author:

Charles Keller

ISBN #:

0130214108

Author:

Charles Keller

ISBN #:

0130499099