Calin D Dumitru

US Patent:

20040126823, Jul 1, 2004

Filed:

Jun 2, 2003

Appl. No.:

10/453806

Inventors:

Philip Tsichlis - Willow Grove PA, US
Calin Dumitru - Philadelphia PA, US
Aristides Eliopoulos - Birmingham, GB

International Classification:

G01N033/574

US Classification:

435/007230

Abstract:

The present invention discloses novel methods to identify compounds potentially useful for the treatment and prevention of inflammation and/or cancer in animals including mammals. It disclose that Tpl2 is required for tumor induction by Akt and Tpl2 is required for the induction of cyclo-oxygenase-2 (COX-2) and prostaglandin synthesis and provides methods to identify compounds that modulate interactions between Tpl-2 and COX-2 or interactions between Tpl-2 and Akt. The present invention also discloses a transgenic Tpl2-/- mouse encoding Akt where the mouse is characterized by its ability to show delayed tumor induction by comparison with a transgenic Tpl2+/+ mouse expressing the Akt and method of treating cancers in animals.