Brian David Hemond

US Patent:

8172790, May 8, 2012

Filed:

Aug 31, 2007

Appl. No.:

12/310456

Inventors:

Ian W. Hunter - Lincoln MA, US
Brian D. Hemond - Lexington MA, US
Dawn M. Wendell - Farmington CT, US
Nora Catherine Hogan - Boston MA, US
Andrew J. Taberner - Epsom, NZ
Nathan B. Ball - Boston MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

A61M 5/30

US Classification:

604 68

Abstract:

A needle-free transdermal transport device includes a chamber () for holding the substance to be injected, a nozzle () in fluid communication with the chamber, and a drug reservoir () for storing the substance to be transferred to the chamber. The needle-free transdermal transport device also includes a controllable magnet and coil electromagnetic actuator () in communication with the chamber. The actuator receives an electrical input and generates in response a force. The force then causes a needle-free transfer of the substance from the chamber to the biological body. The force is variable responsive to variations in the received input during actuation. The actuator draws the substance from the drug reservoir or alternatively, the substance can be pressurized from the drug reservoir into the chamber by a pressure source.

US Patent:

8328755, Dec 11, 2012

Filed:

Oct 18, 2010

Appl. No.:

12/906525

Inventors:

Ian W. Hunter - Lincoln MA, US
Andrew J. Taberner - Lexington MA, US
Brian D. Hemond - Lexington MA, US
Dawn M. Wendell - Farmington CT, US
Nora Catherine Hogan - Boston MA, US
Nathan B. Ball - Cambridge MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

A61M 5/30

US Classification:

604 68

Abstract:

A needle-free transdermal transport device for transferring a substance across a surface of a biological body includes a reservoir for storing the substance, a nozzle in fluid communication with the reservoir and a controllable electromagnetic actuator in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly and a moving coil assembly. The coil assembly moves a piston having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e. g. , servo-controlled) by the electrical input and can be altered during the course of an actuation cycle.

US Patent:

20060258986, Nov 16, 2006

Filed:

Feb 10, 2006

Appl. No.:

11/352916

Inventors:

Ian Hunter - Lincoln MA, US
Andrew Taberner - Lexington MA, US
Brian Hemond - Lexington MA, US
Dawn Wendell - Farmington CT, US
Nora Hogan - Boston MA, US
Nathan Ball - Cambridge MA, US

International Classification:

A61M 5/178

US Classification:

604164010

Abstract:

A needle-free transdermal transport device for transferring a substance across a surface of a biological body includes a reservoir for storing the substance, a nozzle in fluid communication with the reservoir and a controllable electromagnetic actuator in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly and a moving coil assembly. The coil assembly moves a piston having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo-controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.

US Patent:

20070129693, Jun 7, 2007

Filed:

Nov 13, 2006

Appl. No.:

11/598556

Inventors:

Ian Hunter - Lincoln MA, US
Andrew Taberner - Lexington MA, US
Dawn Wendell - Farmington CT, US
Nora Hogan - Boston MA, US
Brian Hemond - Lexington MA, US
Ching-Hua Tseng - Belmont MA, US

International Classification:

A61M 35/00

US Classification:

604294000, 604181000

Abstract:

An eye injector for transferring a substance across the surface of the eye of an animal includes a needle-free injector and a patient positioning mechanism. The needle-free injector includes a reservoir for storing the substance to be transferred, a nozzle in fluid communication with the reservoir; and a controllable electromagnetic actuator in communication with the reservoir. The eye injector can also include a targeting light source for directing a beam of light into a pupil of the eye. The needle-free injector can be positioned adjacent to the lens of the eye, therefore producing a jet that intersects with the beam of light at a point in the retina.

US Patent:

20070191758, Aug 16, 2007

Filed:

Feb 13, 2006

Appl. No.:

11/354279

Inventors:

Ian Hunter - Lincoln MA, US
Andrew Taberner - Lexington MA, US
Brian Hemond - Lexington MA, US
Dawn Wendell - Farmington CT, US
Nora Hogan - Boston MA, US
Nathan Ball - Cambridge MA, US

International Classification:

A61B 17/20
A61M 5/178

US Classification:

604022000, 604164010

Abstract:

A needle-free transdermal transport device for transferring a substance across a surface of a biological body includes a reservoir for storing the substance, a nozzle in fluid communication with the reservoir and a controllable electromagnetic actuator in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly and a moving coil assembly. The coil assembly moves a piston having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo-controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.

US Patent:

20080009788, Jan 10, 2008

Filed:

Feb 10, 2006

Appl. No.:

11/351887

Inventors:

Ian Hunter - Lincoln MA, US
Andrew Taberner - Lexington MA, US
Brian Hemond - Lexington MA, US
Dawn Wendell - Farmington CT, US
Nora Hogan - Boston MA, US
Nathan Ball - Cambridge MA, US

International Classification:

A61M 5/30

US Classification:

604068000, 425130000

Abstract:

A needle-free transdermal transport device for non-axially transferring a substance across a surface of a biological body includes a reservoir for holding a substance being transferred. A piston is positioned within the device in communication with the reservoir. An actuator drives the piston to expel the substance from the reservoir. The reservoir is in fluid communication with a nozzle which includes at least one lateral aperture through which the substance is expelled. Multiple lateral apertures can result in a needle-free transfer across a selectable surface area. The depth and direction of an injection can be controlled by the parameters of the nozzle. By providing a selective depth and direction, it is possible to inject a substance into a targeted biological layer, such as a cleavage plane to further promote coverage. A control source can be used to activate the device. The device can also include an optional power source.

US Patent:

20120089114, Apr 12, 2012

Filed:

Oct 7, 2011

Appl. No.:

13/269421

Inventors:

Brian D. Hemond - Lexington MA, US
Ian W. Hunter - Lincoln MA, US
Andrew J. Taberner - Auckland, NZ
Dawn M. Wendell - Farmington CT, US
N. Catherine Hogan - Boston MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

A61M 5/31
A61M 5/307

US Classification:

604500, 604 65

Abstract:

A method for injecting a substance through a biological body surface includes providing a needle-free transdermal transport device configured to inject the substance through the surface. The substance is injected into the biological body with the transport device while a parameter of the injection is sensed and a servo-controller is used to dynamically adjust at least one injection characteristic based on the sensed parameter. The substance is injected for (i) a first time period during which a first portion of a volume of the substance is injected at a first injection pressure, and (ii) a second time period during which a remainder of the volume of the substance is injected at a second injection pressure. A viscosity of the substance may be determined, and a pressure calculated for injecting the substance based on the viscosity. The substance may be injected with the transport device by using the calculated pressure.

US Patent:

20120205534, Aug 16, 2012

Filed:

Feb 14, 2012

Appl. No.:

13/396321

Inventors:

Ian W. Hunter - Lincoln MA, US
Brian D. Hemond - Cambridge MA, US
Harold F. Hemond - Lexington MA, US

International Classification:

H01J 49/24
H01J 49/26

US Classification:

250282, 250281

Abstract:

A miniature, low cost mass spectrometer capable of unit resolution over a mass range of 10 to 50 AMU. The mass spectrometer incorporates several features that enhance the performance of the design over comparable instruments. An efficient ion source enables relatively low power consumption without sacrificing measurement resolution. Variable geometry mechanical filters allow for variable resolution. An onboard ion pump removes the need for an external pumping source. A magnet and magnetic yoke produce magnetic field regions with different flux densities to run the ion pump and a magnetic sector mass analyzer. An onboard digital controller and power conversion circuit inside the vacuum chamber allows a large degree of flexibility over the operation of the mass spectrometer while eliminating the need for high-voltage electrical feedthroughs. The miniature mass spectrometer senses fractions of a percentage of inlet gas and returns mass spectra data to a computer.