Binhai Zheng

US Patent:

6395487, May 28, 2002

Filed:

Apr 19, 2000

Appl. No.:

09/552219

Inventors:

Allan Bradley - Houston TX
Ramiro Ramirez-Solis - Missouri City TX
Hong Su - Houston TX
Binhai Zheng - Houston TX

Assignee:

Baylor College of Medicine - Houston TX

International Classification:

C12Q 168

US Classification:

435 6, 4353201, 435462, 536 231

Abstract:

The present invention involves the creation of defined chromosomal deficiencies, inversions and duplications using Cre recombinase in ES cells transmitted into the mouse germ line. These chromosomal reconstructions can extend up to 3-4 cM. Chromosomal rearrangements are the major cause of inherited human disease and fetal loss. Additionally, translocations and deletions are recognized as major genetic changes that are causally involved in neoplasia. Chromosomal variants such as deletions and inversions are exploited commonly as genetic tools in organisms such as Drosophila. Mice with defined regions of segmental haploidy are useful for genetic screening and allow accurate models of human chromosomal diseases to be generated.

US Patent:

6461818, Oct 8, 2002

Filed:

Apr 19, 2000

Appl. No.:

09/552626

Inventors:

Allan Bradley - Houston TX
Ramiro Ramirez-Solis - Missouri City TX
Hong Su - Houston TX
Binhai Zheng - Houston TX

Assignee:

Baylor College of Medicine - Houston TX

International Classification:

C12Q 168

US Classification:

435 6, 4351723, 4353201

Abstract:

The present invention involves the creation of defined chromosomal deficiencies, inversions and duplications using Cre recombinase in ES cells transmitted into the mouse germ line. These chromosomal reconstructions can extend up to 3-4 cM. Chromosomal rearrangements are the major cause of inherited human disease and fetal loss. Additionally, translocations and deletions are recognized as major genetic changes that are causally involved in neoplasia. Chromosomal variants such as deletions and inversions are exploited commonly as genetic tools in organisms such as Drosophila. Mice with defined regions of segmental haploidy are useful for genetic screening and allow accurate models of human chromosomal diseases to be generated.

US Patent:

20030084467, May 1, 2003

Filed:

Jul 30, 2002

Appl. No.:

10/209615

Inventors:

Allan Bradley - Houston TX, US
Ramiro Ramirez-Solis - Missouri City TX, US
Hong Su - Houston TX, US
Binhai Zheng - Houston TX, US

Assignee:

BAYLOR - Houston TX

International Classification:

A01K067/027

US Classification:

800/018000, 800/021000

Abstract:

The present invention involves the creation of defined chromosomal deficiencies, inversions and duplications using Cre recombinase in ES cells transmitted into the mouse germ line. These chromosomal reconstructions can extend up to 3-4 cM. Chromosomal rearrangements are the major cause of inherited human disease and fetal loss. Additionally, translocations and deletions are recognized as major genetic changes that are causally involved in neoplasia. Chromosomal variants such as deletions and inversions are exploited commonly as genetic tools in organisms such as Drosophila. Mice with defined regions of segmental haploidy are useful for genetic screening and allow accurate models of human chromosomal disease to be generated.

US Patent:

60776676, Jun 20, 2000

Filed:

Jun 26, 1997

Appl. No.:

8/883616

Inventors:

Allan Bradley - Houston TX
Ramiro Ramirez-Solis - Missouri City TX
Hong Su - Houston TX
Binhai Zheng - Houston TX

International Classification:

C12Q 168
C12N 163
C12N 1587
C07H 2104

US Classification:

435 6

Abstract:

The present invention involves the creation of defined chromosomal deficiencies, inversions and duplications using Cre recombinase in ES cells transmitted into the mouse germ line. These chromosomal reconstructions can extend up to 3-4 cM. Chromosomal rearrangements are the major cause of inherited human disease and fetal loss. Additionally, translocations and deletions are recognized as major genetic changes that are causally involved in neoplasia. Chromosomal variants such as deletions and inversions are exploited commonly as genetic tools in organisms such as Drosophila. Mice with defined regions of segmental haploidy are useful for genetic screening and allow accurate models of human chromosomal diseases to be generated.