Frank G Zheng

US Patent:

20090216300, Aug 27, 2009

Filed:

Jan 18, 2007

Appl. No.:

12/161323

Inventors:

Llew Keltner - Portland OR, US
Jay Winship - Bellevue WA, US
Erik Hagstrom - Woodinville WA, US
Frank Zheng - Kirkland WA, US
James C. Chen - Clyde Hill WA, US
Joseph M. Hobbs - Issaquah WA, US

Assignee:

Light Sciences Oncology, Inc. - Bellevue WA

International Classification:

A61N 5/06

US Classification:

607 89, 607 88

Abstract:

A prostate treatment system having a light delivery device positionable in a transurethral device for treatment of benign prostatic hyperplasia (BPH). The light delivery device includes light generator, such as light emitting diodes (LED), laser diodes (LDs) or a diffusion quartz fiber tip connected to a light generator or a light emitting polymer which produces light at a selected wavelength or waveband or alternative sources of suitable light energy. The treatment device may further include a temperature monitoring system for monitoring the temperature at the treatment site. A light-activated drug is administered to the treatment site prior to light activation. The light-activated drug therapy induces cell death of the target tissue. The device provides a minimally invasive transurethral method for treatment of BPH or prostate cancer.

US Patent:

20210147465, May 20, 2021

Filed:

Aug 28, 2020

Appl. No.:

17/006638

Inventors:

- Menlo Park CA, US
Jeremiah HANES - Menlo Park CA, US
Gene SHEN - Santa Clara CA, US
Louis BROGLEY - Santa Cruz CA, US
Stephen YUE - Eugene OR, US
Frank ZHENG - Fremont CA, US
Yuri LAPIN - Newark CA, US
John LYLE - Fremont CA, US
Honey OSUNA - San Francisco CA, US
Andrei FEDOROV - San Bruno CA, US

Assignee:

Pacific Biosciences of California, Inc. - Menlo Park CA

International Classification:

C07H 19/10
C07F 9/6558
C07F 9/6561
C09B 23/06
C09B 23/08
C09B 69/10

Abstract:

Protected fluorescent reagent compounds and their methods of synthesis are provided. The compounds are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The compounds contain fluorescent dye elements, that allow the compounds to be detected with high sensitivity at desirable wavelengths, binding elements, that allow the compounds to be recognized specifically by target biomolecules, and protective shield elements, that decrease undesirable contacts between the fluorescent dye elements and the bound target biomolecules and that therefore decrease photodamage of the bound target biomolecules by the fluorescent dye elements.

US Patent:

20180346507, Dec 6, 2018

Filed:

Apr 30, 2018

Appl. No.:

15/966334

Inventors:

- Menlo Park CA, US
Jeremiah HANES - Menlo Park CA, US
Gene SHEN - Santa Clara CA, US
Louis BROGLEY - Santa Cruz CA, US
Stephen YUE - Eugene OR, US
Frank ZHENG - Fremont CA, US
Yuri LAPIN - Newark CA, US
John LYLE - Fremont CA, US
Honey OSUNA - San Francisco CA, US
Andrei FEDOROV - San Bruno CA, US

International Classification:

C07H 19/10
C09B 69/10
C09B 23/08
C07F 9/6558
C07F 9/6561
C09B 23/06

Abstract:

Protected fluorescent reagent compounds and their methods of synthesis are provided. The compounds are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The compounds contain fluorescent dye elements, that allow the compounds to be detected with high sensitivity at desirable wavelengths, binding elements, that allow the compounds to be recognized specifically by target biomolecules, and protective shield elements, that decrease undesirable contacts between the fluorescent dye elements and the bound target biomolecules and that therefore decrease photodamage of the bound target biomolecules by the fluorescent dye elements.

US Patent:

20150050659, Feb 19, 2015

Filed:

Aug 5, 2014

Appl. No.:

14/452497

Inventors:

- Menlo Park CA, US
Jeremiah HANES - Menlo Park CA, US
Gene SHEN - Santa Clara CA, US
Louis BROGLEY - Santa Cruz CA, US
Stephen YUE - Eugene OR, US
Frank ZHENG - Fremont CA, US
Yuri LAPIN - Newark CA, US
John LYLE - Fremont CA, US
Honey OSUNA - San Francisco CA, US
Andrei FEDOROV - San Bruno CA, US

International Classification:

C12Q 1/68
C07H 19/20
C07F 9/655

US Classification:

435 612, 544198, 546 25, 536 2723, 548119

Abstract:

Protected fluorescent reagent compounds and their methods of synthesis are provided. The compounds are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The compounds contain fluorescent dye elements, that allow the compounds to be detected with high sensitivity at desirable wavelengths, binding elements, that allow the compounds to be recognized specifically by target biomolecules, and protective shield elements, that decrease undesirable contacts between the fluorescent dye elements and the bound target biomolecules and that therefore decrease photodamage of the bound target biomolecules by the fluorescent dye elements.