Ayla Ergun

US Patent:

20110119259, May 19, 2011

Filed:

Apr 24, 2009

Appl. No.:

12/989083

Inventors:

James J. Collins - Newton MA, US
Zheng Li - St. Louis MO, US
Ayla Ergun - Brookline MA, US

Assignee:

TRUSTEES OF BOSTON UNIVERSITY - Boston MA

International Classification:

G06F 17/30

US Classification:

707723, 707E17014

Abstract:

Described herein is a network biology approach useful for the identification of multiple therapeutic targets, which can be targeted simultaneously using an agent (or a plurality of agents) to modulate cellular phenotypes, or in combination with pharmaceutical compounds to improve drug sensitivity and/or reduce drug doses to maintain efficacy while minimizing side effects. The preferred approach disclosed herein relies on first identifying the mediators of a condition of interest, and second, selecting gene combinations that are in competing/parallel pathways as targets for combination therapy.